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Marcus Fändrich

Marcus Fändrich

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
16038
World Ranking
10665
National Ranking
769

Overview

Marcus Fändrich is affiliated with the University of Ulm in Germany, where their research primarily focuses on biochemistry, genetics, and molecular biology. Their work spans 71 publications in these broad fields, with a particular emphasis on molecular biology, which accounts for 63 of these. Additional studies relate to physiology, materials chemistry, immunology, and nutrition and dietetics.

The scientist's research covers several main topics, including amyloidosis diagnosis, treatment, and outcomes, which is the most frequently addressed area with 62 publications. Other significant topics include Alzheimer's disease research and treatments, protein structure and dynamics, prion diseases and protein misfolding, enzyme structure and function, trace elements in health, and advanced NMR techniques and applications.

Marcus Fändrich has contributed to various well-known scientific journals and platforms. Frequent publication venues include:

  • EMPIAR dataset
  • Nature Communications
  • Journal of Molecular Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Amyloid

Recent notable papers authored or coauthored by Marcus Fändrich are:

  • Half a century of amyloids: past, present and future, 2020, Chemical Society Reviews
  • Amyloid nomenclature 2022: update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee, 2022, Amyloid
  • Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis, 2021, Nature Communications
  • Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM, 2021, Nature Communications
  • Amyloid nomenclature 2024: update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee, 2024, Amyloid

Their work often involves collaboration, with frequent coauthors including Matthias Schmidt, Christian Haupt, Ute Hegenbart, Stefan Schönland, and Sebastian Wiese. These partnerships reflect an ongoing engagement with experts in related fields, reinforcing interdisciplinary approaches within their research.

Best Publications

  • Amyloid fibrils from muscle myoglobin

    Marcus Fändrich;Matthew A. Fletcher;Christopher M. Dobson

  • The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation.

    Marcus Fändrich;Marcus Fändrich;Christopher M. Dobson;Christopher M. Dobson

  • Half a century of amyloids: past, present and future

    Pu Chun Ke;Pu Chun Ke;Ruhong Zhou;Ruhong Zhou;Louise C. Serpell;Roland Riek

  • Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

    Jan Bieschke;Martin Herbst;Martin Herbst;Thomas Wiglenda;Ralf P Friedrich

  • Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue.

    Marius Kollmer;William Close;Leonie Funk;Jay Rasmussen

  • Oligomeric intermediates in amyloid formation: structure determination and mechanisms of toxicity.

    Marcus Fändrich

  • Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments

    Marcus Fändrich;Vincent Forge;Katrin Buder;Marlis Kittler

  • Mechanism of amyloid plaque formation suggests an intracellular basis of Aβ pathogenicity

    Ralf P. Friedrich;Katharina Tepper;Raik Rönicke;Malle Soom

  • Structural polymorphism of Alzheimer Aβ and other amyloid fibrils

    Marcus Fändrich;Jessica Meinhardt;Nikolaus Grigorieff

  • Aβ(1-40) Fibril Polymorphism Implies Diverse Interaction Patterns in Amyloid Fibrils

    Jessica Meinhardt;Carsten Sachse;Carsten Sachse;Peter Hortschansky;Nikolaus Grigorieff

  • On the structural definition of amyloid fibrils and other polypeptide aggregates

    Fändrich M

  • Comparison of Alzheimer Aβ(1–40) and Aβ(1–42) amyloid fibrils reveals similar protofilament structures

    Matthias Schmidt;Carsten Sachse;Walter Richter;Chen Xu

  • Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease

    Dietmar Rudolf Thal;Jochen Walter;Takaomi C. Saido;Marcus Fändrich

  • Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

    Raik Rönicke;Marina Mikhaylova;Sabine Rönicke;Jessica Meinhardt

  • High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus.

    Carsten Sachse;James Z. Chen;Pierre-Damien Coureux;M. Elizabeth Stroupe

  • AA Amyloidosis: Pathogenesis and Targeted Therapy

    Gunilla T Westermark;Marcus Fändrich;Per Westermark

  • Raft lipids as common components of human extracellular amyloid fibrils.

    Gerald P. Gellermann;Thomas R. Appel;Astrid Tannert;Anja Radestock

  • Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils

    Gernot Habicht;Christian Haupt;Ralf P. Friedrich;Peter Hortschansky

  • Effect of Different Salt Ions on the Propensity of Aggregation and on the Structure of Alzheimer’s Aβ(1-40) Amyloid Fibrils

    Karolin Klement;Karin Wieligmann;Jessica Meinhardt;Peter Hortschansky

  • Paired β-sheet structure of an Aβ(1-40) amyloid fibril revealed by electron microscopy

    Carsten Sachse;Marcus Fändrich;Nikolaus Grigorieff

Frequent Co-Authors

Nikolaus Grigorieff
Nikolaus Grigorieff Howard Hughes Medical Institute
Gunilla T. Westermark
Gunilla T. Westermark Uppsala University
Per Westermark
Per Westermark Uppsala University
Klaus G. Reymann
Klaus G. Reymann Leibniz Institute for Neurobiology
Bernd Reif
Bernd Reif Technical University of Munich
Thomas Simmet
Thomas Simmet University of Ulm
Christoph Röcken
Christoph Röcken Kiel University
Matthias Staufenbiel
Matthias Staufenbiel University of Tübingen
Günter Fritz
Günter Fritz University of Hohenheim
Jan Münch
Jan Münch University of Ulm

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