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Ayyalusamy Ramamoorthy

Ayyalusamy Ramamoorthy

D-Index & Metrics

Chemistry

D-Index
104
Citations
37290
World Ranking
1064
National Ranking
427

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Ayyalusamy Ramamoorthy is affiliated with Florida State University in the United States and has a research portfolio focused on biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their scholarly output includes 87 publications related to biochemistry, genetics, and molecular biology and 43 publications linked to medicine.

Their work spans several subfields including molecular biology, physiology, spectroscopy, biomaterials, and materials chemistry, showing an interdisciplinary approach to biological and chemical studies.

Ramamoorthy's research topics cover a diverse range of scientific areas, including:

  • Alzheimer's disease research and treatments
  • Lipid Membrane Structure and Behavior
  • Advanced NMR Techniques and Applications
  • Protein Structure and Dynamics
  • Supramolecular Self-Assembly in Materials
  • NMR spectroscopy and applications
  • Electron Spin Resonance Studies

Frequent publication venues for Ramamoorthy include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Chemical Communications
  • Langmuir
  • Biomolecules
  • Chemical Reviews

They have collaborated often with several coauthors, including Thirupathi Ravula, Bankala Krishnarjuna, Bikash R. Sahoo, Magdalena I. Ivanova, and Samuel D. McCalpin.

Recent publications reflect a focus on amyloid-related diseases and advanced spectroscopy methodologies. Selected papers include:

  • "Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis" (2021, Chemical Reviews)
  • "Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes" (2021, Chemical Reviews)
  • "Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology" (2020, Biophysical Chemistry)
  • "Ultrafast Magic Angle Spinning Solid-State NMR Spectroscopy: Advances in Methodology and Applications" (2022, Chemical Reviews)
  • "Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins" (2020, ACS Chemical Neuroscience)

Their work integrates experimental and computational methods, particularly in the study of amyloid proteins involved in neurodegenerative and metabolic diseases. The scientist has contributed to advancing methodologies in solid-state NMR spectroscopy and exploring lipid membrane interactions.

Recognition of their contributions includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2009.

Best Publications

  • Ultrastrong and Stiff Layered Polymer Nanocomposites

    Paul Podsiadlo;Amit K. Kaushik;Ellen M. Arruda;Anthony M. Waas

  • Studies on anticancer activities of antimicrobial peptides.

    David W. Hoskin;Ayyalusamy Ramamoorthy

  • LL-37, the only human member of the cathelicidin family of antimicrobial peptides.

    Ulrich H.N. Dürr;U.S. Sudheendra;Ayyalusamy Ramamoorthy

  • Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37.

    Katherine A. Henzler Wildman;Dong Kuk Lee;A. Ramamoorthy

  • Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis

    Phuong H. Nguyen;Ayyalusamy Ramamoorthy;Bikash R. Sahoo;Jie Zheng

  • High-Resolution Heteronuclear Dipolar Solid-State NMR Spectroscopy

    C.H. Wu;A. Ramamoorthy;S.J. Opella

  • A partially folded structure of amyloid-beta(1-40) in an aqueous environment.

    Subramanian Vivekanandan;Jeffrey R. Brender;Shirley Y. Lee;Ayyalusamy Ramamoorthy

  • Bicelles - A much needed magic wand to study membrane proteins by NMR spectroscopy

    Ronald Soong;Jiadi Xu;Ayyalusamy Ramamoorthy

  • The human beta-defensin-3, an antibacterial peptide with multiple biological functions

    Vishnu Dhople;Amy Krukemeyer;Ayyalusamy Ramamoorthy

  • MSI-78, an Analogue of the Magainin Antimicrobial Peptides, Disrupts Lipid Bilayer Structure via Positive Curvature Strain

    Kevin J. Hallock;Dong Kuk Lee;A. Ramamoorthy

  • Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease.

    Samuel A. Kotler;Patrick Walsh;Jeffrey R. Brender;Ayyalusamy Ramamoorthy

  • Misfolded proteins in Alzheimer's disease and type II diabetes

    Alaina S. DeToma;Samer Salamekh;Ayyalusamy Ramamoorthy;Mi Hee Lim

  • Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective.

    Jeffrey R. Brender;Samer Salamekh;Ayyalusamy Ramamoorthy

  • Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation

    Michele F M Sciacca;Samuel A. Kotler;Jeffrey R. Brender;Jennifer Chen

  • Structure, membrane orientation, mechanism, and function of pexiganan--a highly potent antimicrobial peptide designed from magainin.

    Lindsey M. Gottler;Ayyalusamy Ramamoorthy

  • The magic of bicelles lights up membrane protein structure.

    Ulrich H. N. Dürr;Melissa Gildenberg;Ayyalusamy Ramamoorthy

  • Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin.

    Jeffrey Barry;Michelle Fritz;Jeffrey R. Brender;Pieter E S Smith

  • Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37.

    Katherine A. Henzler-Wildman;Gary V. Martinez;Michael F. Brown;A. Ramamoorthy

  • Design of small molecules that target metal-Aβ species and regulate metal-induced Aβ aggregation and neurotoxicity

    Jung Suk Choi;Joseph J. Braymer;Ravi P R Nanga;Ayyalusamy Ramamoorthy

  • Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

    Ravi Prakash Reddy Nanga;Jeffrey R. Brender;Subramanian Vivekanandan;Ayyalusamy Ramamoorthy

  • Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins.

    Seong Il Yoo;Ming Yang;Jeffrey R. Brender;Vivekanandan Subramanian

Frequent Co-Authors

Jeffrey R. Brender
Jeffrey R. Brender National Institutes of Health
Lucy Waskell
Lucy Waskell University of Michigan–Ann Arbor
Mi Hee Lim
Mi Hee Lim Korea Advanced Institute of Science and Technology
G. M. Anantharamaiah
G. M. Anantharamaiah University of Alabama at Birmingham
Carol A. Fierke
Carol A. Fierke Texas A&M University
Stanley J. Opella
Stanley J. Opella University of California, San Diego
Michael D. Morris
Michael D. Morris University of Michigan–Ann Arbor
David H. Kohn
David H. Kohn University of Michigan–Ann Arbor
Brandon T. Ruotolo
Brandon T. Ruotolo University of Michigan–Ann Arbor
Gianluigi Veglia
Gianluigi Veglia University of Minnesota

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