World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
49
Citations
8910
World Ranking
14796
National Ranking
3780

Biology and Biochemistry

D-Index
49
Citations
8875
World Ranking
18009
National Ranking
7367

Overview

Jeffrey R. Brender is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on medicine and biochemistry, genetics, and molecular biology, with significant contributions in subfields such as radiology, nuclear medicine and imaging, oncology, molecular biology, cancer research, and immunology.

Their research covers a range of topics, including:

  • Cancer Immunotherapy and Biomarkers
  • Molecular Biology Techniques and Applications
  • Advanced MRI Techniques and Applications
  • Immune Cell Function and Interaction
  • Cancer, Hypoxia, and Metabolism
  • Radiopharmaceutical Chemistry and Applications
  • Advanced NMR Techniques and Applications

Brender has published extensively in several venues, including:

  • Harvard Dataverse
  • Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Magnetic Resonance in Medicine
  • Cancer Research

Their recent papers include:

  • "Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy" (2020), published in Cell Reports
  • "Quality of Prostate MRI: Is the PI-RADS Standard Sufficient?" (2020), published in Academic Radiology
  • "Hypoxia-Activated Prodrug Evofosfamide Treatment in Pancreatic Ductal Adenocarcinoma Xenografts Alters the Tumor Redox Status to Potentiate Radiotherapy" (2020), published in Antioxidants and Redox Signaling
  • "Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13C MRSI" (2020), published in Magnetic Resonance in Medicine
  • "Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma" (2020), published in Cancer Research

Brender has collaborated frequently with several researchers, notably:

  • Shun Kishimoto
  • Murali C. Krishna
  • Kazutoshi Yamamoto
  • Nallathamby Devasahayam
  • Yasunori Otowa

Best Publications

  • A partially folded structure of amyloid-beta(1-40) in an aqueous environment.

    Subramanian Vivekanandan;Jeffrey R. Brender;Shirley Y. Lee;Ayyalusamy Ramamoorthy

  • Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease.

    Samuel A. Kotler;Patrick Walsh;Jeffrey R. Brender;Ayyalusamy Ramamoorthy

  • Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective.

    Jeffrey R. Brender;Samer Salamekh;Ayyalusamy Ramamoorthy

  • Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation

    Michele F M Sciacca;Samuel A. Kotler;Jeffrey R. Brender;Jennifer Chen

  • Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin.

    Jeffrey Barry;Michelle Fritz;Jeffrey R. Brender;Pieter E S Smith

  • Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

    Ravi Prakash Reddy Nanga;Jeffrey R. Brender;Subramanian Vivekanandan;Ayyalusamy Ramamoorthy

  • Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins.

    Seong Il Yoo;Ming Yang;Jeffrey R. Brender;Vivekanandan Subramanian

  • Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide.

    Jeffrey R. Brender;Edgar L. Lee;Marchello A. Cavitt;Ari Gafni

  • Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species

    Suk Joon Hyung;Alaina S. Detoma;Jeffrey R. Brender;Sanghyun Lee

  • Role of Zinc in Human Islet Amyloid Polypeptide Aggregation

    Jeffrey R Brender;Kevin Hartman;Ravi Prakash Reddy Nanga;Nataliya Popovych

  • A Single Mutation in the Nonamyloidogenic Region of Islet Amyloid Polypeptide Greatly Reduces Toxicity

    Jeffrey R. Brender;Kevin Hartman;Kendra R. Reid;Robert T. Kennedy

  • Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

    Sanghyun Lee;Xueyun Zheng;Janarthanan Krishnamoorthy;Masha G. Savelieff

  • Structures of Rat and Human Islet Amyloid Polypeptide IAPP1−19 in Micelles by NMR Spectroscopy†

    Ravi Prakash Reddy Nanga;Jeffrey R. Brender;Jiadi Xu;Gianluigi Veglia

  • Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F Nuclear Magnetic Resonance-Detected Kinetics of Monomer Consumption

    Yuta Suzuki;Jeffrey R. Brender;Kevin Hartman;Ayyalusamy Ramamoorthy

  • Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy.

    Ravi Prakash Reddy Nanga;Jeffrey R. Brender;Jiadi Xu;Kevin Hartman

  • Association of highly compact type II diabetes related islet amyloid polypeptide intermediate species at physiological temperature revealed by diffusion NMR spectroscopy.

    Ronald Soong;Jeffrey R. Brender;Peter M. Macdonald;Ayyalusamy Ramamoorthy

  • Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide.

    Pieter E. S. Smith;Jeffrey R. Brender;Ayyalusamy Ramamoorthy

  • Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives.

    Amit Pithadia;Jeffrey R. Brender;Carol A. Fierke;Ayyalusamy Ramamoorthy

  • Membrane Fragmentation by an Amyloidogenic Fragment of Human Islet Amyloid Polypeptide Detected by Solid-State NMR Spectroscopy of Membrane Nanotubes

    Jeffrey R. Brender;Ulrich H.N. Dürr;Deborah Heyl;Mahender B. Budarapu

  • Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles.

    Jeffrey R. Brender;Yang Zhang

Frequent Co-Authors

Ayyalusamy Ramamoorthy
Ayyalusamy Ramamoorthy Florida State University
Yang Zhang
Yang Zhang University of Michigan–Ann Arbor
Peter L. Choyke
Peter L. Choyke National Institutes of Health
Mi Hee Lim
Mi Hee Lim Korea Advanced Institute of Science and Technology
James B. Mitchell
James B. Mitchell National Institutes of Health
Nicholas A. Kotov
Nicholas A. Kotov University of Michigan–Ann Arbor
E. Neil G. Marsh
E. Neil G. Marsh University of Michigan–Ann Arbor
Brandon T. Ruotolo
Brandon T. Ruotolo University of Michigan–Ann Arbor
James E. Mitchell
James E. Mitchell University of North Dakota
Peter M. Macdonald
Peter M. Macdonald University of Toronto

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