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Guanghong Wei

Guanghong Wei

D-Index & Metrics

Chemistry

D-Index
54
Citations
9000
World Ranking
12767
National Ranking
2005

Overview

Guanghong Wei is affiliated with Fudan University in China, contributing extensively to the fields of biochemistry, genetics, and molecular biology, as well as medicine. Their research covers a variety of interdisciplinary areas within these domains, with a particular focus on molecular biology, physiology, biomaterials, organic chemistry, and neurology.

The scientist's main topics of study include:

  • Alzheimer's disease research and treatments
  • Supramolecular Self-Assembly in Materials
  • Protein Structure and Dynamics
  • RNA Research and Splicing
  • Polydiacetylene-based materials and applications
  • Parkinson's Disease Mechanisms and Treatments
  • Chemical Synthesis and Analysis

Guanghong Wei has published frequently in notable scientific journals. The principal publication venues include:

  • Physical Chemistry Chemical Physics
  • ACS Chemical Neuroscience
  • The Journal of Physical Chemistry B
  • International Journal of Biological Macromolecules
  • Small

Among recent publications, several papers stand out by topic, year, and venue:

  • Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis, 2021, Chemical Reviews
  • Nanoengineered Peptide-Based Antimicrobial Conductive Supramolecular Biomaterial for Cardiac Tissue Engineering, 2021, Advanced Materials
  • Green Tea Extracts EGCG and EGC Display Distinct Mechanisms in Disrupting Aβ42 Protofibril, 2020, ACS Chemical Neuroscience
  • Unusual Two-Step Assembly of a Minimalistic Dipeptide-Based Functional Hypergelator, 2020, Advanced Materials
  • Expanding the Structural Diversity and Functional Scope of Diphenylalanine-Based Peptide Architectures by Hierarchical Coassembly, 2021, Journal of the American Chemical Society

Collaborations are an important aspect of Guanghong Wei's work. Frequent co-authors include:

  • Yiming Tang
  • Yifei Yao
  • Xuewei Dong
  • Yujie Chen
  • Ehud Gazit

The body of research produced by Guanghong Wei integrates experimental and computational approaches, addressing challenges in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, as well as developments in biomaterials and peptide-based assemblies.

Best Publications

  • Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis

    Phuong H. Nguyen;Ayyalusamy Ramamoorthy;Bikash R. Sahoo;Jie Zheng

  • Protein Ensembles: How Does Nature Harness Thermodynamic Fluctuations for Life? The Diverse Functional Roles of Conformational Ensembles in the Cell.

    Guanghong Wei;Wenhui Xi;Ruth Nussinov;Buyong Ma

  • Probing the Self-Assembly Mechanism of Diphenylalanine-Based Peptide Nanovesicles and Nanotubes

    Cong Guo;Yin Luo;Ruhong Zhou;Guanghong Wei

  • Effects of Solvent on the Structure of the Alzheimer Amyloid-β(25–35) Peptide

    Guanghong Wei;Joan-Emma Shea

  • Plugging into Proteins: Poisoning Protein Function by a Hydrophobic Nanoparticle

    Guanghong Zuo;Guanghong Zuo;Qing Huang;Guanghong Wei;Ruhong Zhou;Ruhong Zhou

  • Carbon nanotube inhibits the formation of β-sheet-rich oligomers of the Alzheimer's amyloid-β(16-22) peptide.

    Huiyu Li;Yin Luo;Philippe Derreumaux;Guanghong Wei

  • The molecular mechanism of fullerene-inhibited aggregation of Alzheimer's β-amyloid peptide fragment

    Luogang Xie;Yin Luo;Dongdong Lin;Wenhui Xi

  • Pathway Complexity of Alzheimer's β-Amyloid Aβ16-22 Peptide Assembly

    Sébastien Santini;Guanghong Wei;Normand Mousseau;Philippe Derreumaux

  • Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier

    Bin Dai;Dan Li;Wenhui Xi;Fang Luo

  • Triphenylalanine peptides self-assemble into nanospheres and nanorods that are different from the nanovesicles and nanotubes formed by diphenylalanine peptides.

    Cong Guo;Yin Luo;Ruhong Zhou;Ruhong Zhou;Guanghong Wei

  • Thermodynamics and dynamics of amyloid peptide oligomerization are sequence dependent

    Yan Lu;Philippe Derreumaux;Zhi Guo;Normand Mousseau

  • Nanoengineered Peptide-Based Antimicrobial Conductive Supramolecular Biomaterial for Cardiac Tissue Engineering.

    Priyadarshi Chakraborty;Hadas Oved;Darya Bychenko;Yifei Yao

  • Structural Polymorphism in a Self-Assembled Tri-Aromatic Peptide System

    Noam Brown;Jiangtao Lei;Chendi Zhan;Linda J. W. Shimon

  • Structural diversity of dimers of the Alzheimer amyloid-β(25–35) peptide and polymorphism of the resulting fibrils

    Guanghong Wei;Andrew I. Jewett;Joan-Emma Shea

  • Norepinephrine Inhibits Alzheimer’s Amyloid-β Peptide Aggregation and Destabilizes Amyloid-β Protofibrils: A Molecular Dynamics Simulation Study

    Yu Zou;Zhenyu Qian;Yujie Chen;Hongsheng Qian

  • Expanding the Nanoarchitectural Diversity Through Aromatic Di- and Tri-Peptide Coassembly: Nanostructures and Molecular Mechanisms

    Cong Guo;Zohar A. Arnon;Ruxi Qi;Qingwen Zhang

  • Replica Exchange Molecular Dynamics: A Practical Application Protocol with Solutions to Common Problems and a Peptide Aggregation and Self-Assembly Example

    Ruxi Qi;Guanghong Wei;Buyong Ma;Ruth Nussinov;Ruth Nussinov

  • Structural Insight into Tau Protein’s Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and Aggregation

    Yin Luo;Buyong Ma;Ruth Nussinov;Guanghong Wei

  • Complex folding pathways in a simple β-hairpin

    Guanghong Wei;Normand Mousseau;Philippe Derreumaux

  • Green Tea Extracts EGCG and EGC Display Distinct Mechanisms in Disrupting Aβ42 Protofibril.

    Chendi Zhan;Yujie Chen;Yiming Tang;Guanghong Wei

  • Induced β-Barrel Formation of the Alzheimer's Aβ25–35 Oligomers on Carbon Nanotube Surfaces: Implication for Amyloid Fibril Inhibition

    Zhaoming Fu;Yin Luo;Philippe Derreumaux;Guanghong Wei

  • Conformational Ensemble of hIAPP Dimer: Insight into the Molecular Mechanism by which a Green Tea Extract inhibits hIAPP Aggregation

    Yuxiang Mo;Jiangtao Lei;Yunxiang Sun;Qingwen Zhang

Frequent Co-Authors

Ruth Nussinov
Ruth Nussinov National Institutes of Health
Buyong Ma
Buyong Ma Shanghai Jiao Tong University
Ehud Gazit
Ehud Gazit Tel Aviv University
Philippe Derreumaux
Philippe Derreumaux Ton Duc Thang University
David S. Waugh
David S. Waugh National Institutes of Health
Ruhong Zhou
Ruhong Zhou Columbia University
Zongxian Yang
Zongxian Yang Henan Normal University
Jie Zheng
Jie Zheng University of Akron
Ayyalusamy Ramamoorthy
Ayyalusamy Ramamoorthy Florida State University
Yanlian Yang
Yanlian Yang University of Chinese Academy of Sciences

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