2026 David S. Waugh: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	58	13075	12028	5575	4987	232	13782

Overview

David S. Waugh is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant body of work spreading across related subfields including molecular biology, genetics, public health, environmental and occupational health, organic chemistry, and biochemistry.

The main topics covered in Waugh's research include:

Mosquito-borne diseases and control
RNA and protein synthesis mechanisms
Cancer therapeutics and mechanisms
Phenothiazines and benzothiazines synthesis and activities
Synthesis and catalytic reactions
Polyamine metabolism and applications
Amino acid enzymes and metabolism

Waugh has contributed to several recent papers spanning various journals and areas of study. Selected publications include:

"Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites," 2021, Chemical Science
"Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus," 2021, PLoS ONE
"Specificity Studies of the Venezuelan Equine Encephalitis Virus Non-Structural Protein 2 Protease Using Recombinant Fluorescent Substrates," 2020, International Journal of Molecular Sciences
"Self-inhibited State of Venezuelan Equine Encephalitis Virus (VEEV) nsP2 Cysteine Protease: A Crystallographic and Molecular Dynamics Analysis," 2023, Journal of Molecular Biology
"Sustainable and effective antimicrobial surface based on cellulose thin films," 2022, arXiv (Cornell University)

Frequent co-authors collaborating with Waugh include:

G.T. Lountos
Joseph E. Tropea
D. Needle
Gyula Hoffka
József Tőzsér

Waugh regularly publishes in specialized venues such as:

Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
Chemical Science
PLoS ONE
Journal of Molecular Biology
International Journal of Molecular Sciences

Best Publications

Escherichia coli maltose-binding protein is uncommonly effective at promoting the solubility of polypeptides to which it is fused.

Rachel B. Kapust;David S. Waugh

1389
Citations
Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency.

Rachel B. Kapust;József Tözsér;Jeffrey D. Fox;D.Eric Anderson

1007
Citations
Expression and Purification of Soluble His 6 -Tagged TEV Protease

Joseph E. Tropea;Scott Cherry;David S. Waugh

476
Citations
The P1' specificity of tobacco etch virus protease.

Rachel B Kapust;József Tözsér;Terry D Copeland;David S Waugh

468
Citations
An overview of enzymatic reagents for the removal of affinity tags

David S. Waugh

410
Citations
Crystallographic and Modeling Studies of RNase III Suggest a Mechanism for Double-Stranded RNA Cleavage

Jaroslaw Blaszczyk;Joseph E. Tropea;Mikhail Bubunenko;Karen M. Routzahn

359
Citations
Structural basis for the substrate specificity of tobacco etch virus protease.

Jason Phan;Alexander Zdanov;Artem G. Evdokimov;Joseph E. Tropea

331
Citations
Structural Insight into the Mechanism of Double-Stranded RNA Processing by Ribonuclease III

Jianhua Gan;Joseph E. Tropea;Brian P. Austin;Donald L. Court

324
Citations
The 8-nucleotide-long RNA:DNA hybrid is a primary stability determinant of the RNA polymerase II elongation complex.

Maria L. Kireeva;Natalia Komissarova;David S. Waugh;Mikhail Kashlev

286
Citations
Controlled intracellular processing of fusion proteins by TEV protease.

Rachel B. Kapust;David S. Waugh

282
Citations
Gateway vectors for the production of combinatorially-tagged His6-MBP fusion proteins in the cytoplasm and periplasm of Escherichia coli

Sreedevi Nallamsetty;Brian P. Austin;Kerri J. Penrose;David S. Waugh

248
Citations
Solubility-enhancing proteins MBP and NusA play a passive role in the folding of their fusion partners.

Sreedevi Nallamsetty;David S. Waugh

245
Citations
Crystal structure of plant aspartic proteinase prophytepsin: inactivation and vacuolar targeting.

Jukka Kervinen;Gregory J. Tobin;Júlia Costa;David S. Waugh

222
Citations
Single amino acid substitutions on the surface of Escherichia coli maltose-binding protein can have a profound impact on the solubility of fusion proteins

Jeffrey D. Fox;Rachel B. Kapust;David S. Waugh

214
Citations
Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit.

Evdokimov Ag;Anderson De;Routzahn Km;Waugh Ds

209
Citations
The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague.

Urszula Derewenda;Agnieszka Mateja;Yancho Devedjiev;Karen M. Routzahn

198
Citations
Noncatalytic Assembly of Ribonuclease III with Double-Stranded RNA

Jaroslaw Blaszczyk;Jianhua Gan;Joseph E Tropea;Donald L Court

177
Citations
Efficient site-specific processing of fusion proteins by tobacco vein mottling virus protease in vivo and in vitro.

Sreedevi Nallamsetty;Rachel B. Kapust;József Tözsér;Scott Cherry

172
Citations
Differential effects of short affinity tags on the crystallization of Pyrococcus furiosus maltodextrin-binding protein.

Matthew H. Bucher;Artem G. Evdokimov;David S. Waugh

164
Citations
Maltodextrin-binding proteins from diverse bacteria and archaea are potent solubility enhancers

Jeffrey D. Fox;Karen M. Routzahn;Matthew H. Bucher;David S. Waugh

164
Citations