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Biology and Biochemistry

D-Index
53
Citations
10819
World Ranking
16105
National Ranking
6674

Overview

Mikhail Kashlev is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with a concentration on molecular biology and genetics. They have contributed significantly to topics including RNA and protein synthesis mechanisms, bacterial genetics and biotechnology, RNA modifications and cancer, genomics and chromatin dynamics, RNA research and splicing, bacteriophages and microbial interactions, and genomics and phylogenetic studies.

The scientist's recent publications illustrate an emphasis on transcription factors, RNA polymerase activity, and bacterial gene expression regulation. Notable papers include:

  • "NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA," 2021, eLife
  • "NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome," 2020, Proceedings of the National Academy of Sciences
  • "Comprehensive transcription terminator atlas for Bacillus subtilis," 2022, Nature Microbiology
  • "Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis," 2022, Journal of Bacteriology
  • "NusG-dependent RNA polymerase pausing is a frequent function of this universally conserved transcription elongation factor," 2020, Critical Reviews in Biochemistry and Molecular Biology

Mikhail Kashlev actively collaborates with several frequent coauthors, including Paul Babitzke, Alexander V. Yakhnin, Zachary F. Mandell, Lucyna Lubkowska, and Zhe Sun, reflecting interdisciplinary teamwork within molecular biology and bacterial genetics.

The scientist has published predominantly in certain venues, with multiple papers appearing in bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Nature Communications, Nucleic Acids Research, and eLife.

Best Publications

  • CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

    Sanjeev Shukla;Ersen Kavak;Ersen Kavak;Melissa Gregory;Masahiko Imashimizu

  • Nucleosome Remodeling Induced by RNA Polymerase II: Loss of the H2A/H2B Dimer during Transcription

    Maria L Kireeva;Wendy Walter;Vladimir Tchernajenko;Vladimir Bondarenko

  • Escherichia coli RNA Polymerase Activity Observed Using Atomic Force Microscopy

    Sandor Kasas;Neil H. Thomson;Bettye L. Smith;Helen G. Hansma

  • Transcriptional arrest: Escherichia coli RNA polymerase translocates backward, leaving the 3' end of the RNA intact and extruded.

    Natalia Komissarova;Mikhail Kashlev

  • Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II.

    Courtney Hodges;Lacramioara Bintu;Lucyna Lubkowska;Mikhail Kashlev

  • RNA Polymerase Switches between Inactivated and Activated States By Translocating Back and Forth along the DNA and the RNA

    Natalia Komissarova;Mikhail Kashlev

  • Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner

    Eric A. Galburt;Stephan W. Grill;Anna Wiedmann;Lucyna Lubkowska

  • The 8-nucleotide-long RNA:DNA hybrid is a primary stability determinant of the RNA polymerase II elongation complex.

    Maria L. Kireeva;Natalia Komissarova;David S. Waugh;Mikhail Kashlev

  • Motion and enzymatic degradation of DNA in the atomic force microscope.

    M. Bezanilla;B. Drake;E. Nudler;M. Kashlev

  • Nature of the Nucleosomal Barrier to RNA Polymerase II

    Maria L. Kireeva;Brynne Hancock;Gina H. Cremona;Wendy Walter

  • Crucial Role of the RNA:DNA Hybrid in the Processivity of Transcription

    Igor Sidorenkov;Natalia Komissarova;Mikhail Kashlev

  • Mapping of Catalytic Residues in the RNA Polymerase Active Center

    Evgeny Zaychikov;Emil Martin;Ludmila Denissova;Maxim Kozlov

  • Discontinuous mechanism of transcription elongation

    Evgeny Nudler;Alex Goldfarb;Mikhail Kashlev

  • Nucleosomal Elements That Control the Topography of the Barrier to Transcription

    Lacramioara Bintu;Toyotaka Ishibashi;Manchuta Dangkulwanich;Yueh-Yi Wu

  • Transient reversal of RNA polymerase II active site closing controls fidelity of transcription elongation.

    Maria L. Kireeva;Yuri A. Nedialkov;Gina H. Cremona;Yuri A. Purtov

  • Shortening of RNA:DNA hybrid in the elongation complex of RNA polymerase is a prerequisite for transcription termination.

    Natalia Komissarova;Jodi Becker;Stephanie Solter;Maria Kireeva

  • Coupling between transcription termination and RNA polymerase inchworming

    Evgeny Nudler;Mikhail Kashlev;Vadim Nikiforov;Alex Goldfarb

  • Mechanism of sequence-specific pausing of bacterial RNA polymerase

    Maria L. Kireeva;Mikhail Kashlev

  • The elongation rate of RNA polymerase determines the fate of transcribed nucleosomes

    Lacramioara Bintu;Marta Kopaczynska;Marta Kopaczynska;Courtney Hodges;Courtney Hodges;Lucyna Lubkowska

  • Functional topography of nascent RNA in elongation intermediates of RNA polymerase

    Natalia Komissarova;Mikhail Kashlev

Frequent Co-Authors

Carlos Bustamante
Carlos Bustamante Stanford University
Jeffrey N. Strathern
Jeffrey N. Strathern National Institutes of Health
Alex Goldfarb
Alex Goldfarb Inozyme Pharma
Evgeny Nudler
Evgeny Nudler New York University
Paul Babitzke
Paul Babitzke Pennsylvania State University
Paul K. Hansma
Paul K. Hansma University of California, Santa Barbara
Konstantin Severinov
Konstantin Severinov Rutgers, The State University of New Jersey
Donald L. Court
Donald L. Court National Institutes of Health
Eric T. Kool
Eric T. Kool Stanford University
John F. Atkins
John F. Atkins University College Cork

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