World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
83
Citations
22836
World Ranking
907
National Ranking
480

Research.com Recognitions

  • 2008 - Member of the National Academy of Sciences

Overview

Seth A. Darst is affiliated with Rockefeller University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with 108 publications in these fields. They have contributed to subfields including molecular biology, infectious diseases, genetics, ecology, and structural biology.

The scientist's work covers a range of specialized topics, notably RNA and protein synthesis mechanisms, bacteriophages and microbial interactions, bacterial genetics and biotechnology, viral gastroenteritis research and epidemiology, SARS-CoV-2 and COVID-19 research, RNA research and splicing, as well as advanced electron microscopy techniques and applications.

Frequent publication venues include:

  • EMPIAR dataset
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Molecular Cell
  • Nature Structural & Molecular Biology

Common coauthors that have appeared regularly in their research are:

  • Elizabeth A. Campbell
  • James Chen
  • Brandon Malone
  • Edward T. Eng
  • Paul Dominic B. Olinares

Selected recent publications include:

  • Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex, 2020, Cell
  • Time-resolved cryo-EM using Spotiton, 2020, Nature Methods
  • Stepwise Promoter Melting by Bacterial RNA Polymerase, 2020, Molecular Cell
  • Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex, 2021, Proceedings of the National Academy of Sciences
  • Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex, 2022, Nature Structural & Molecular Biology

Seth A. Darst was recognized as a Member of the National Academy of Sciences in 2008.

Best Publications

  • Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase

    Elizabeth A. Campbell;Nataliya Korzheva;Arkady Mustaev;Katsuhiko Murakami

  • Crystal Structure of Thermus aquaticus Core RNA Polymerase at 3.3 Å Resolution

    Gongyi Zhang;Elizabeth A Campbell;Leonid Minakhin;Catherine Richter

  • Structural Basis of Transcription Initiation: An RNA Polymerase Holoenzyme-DNA Complex

    Katsuhiko S. Murakami;Shoko Masuda;Elizabeth A. Campbell;Oriana Muzzin

  • Structure of the Bacterial RNA Polymerase Promoter Specificity σ Subunit

    Elizabeth A. Campbell;Oriana Muzzin;Mark Chlenov;Jing L. Sun

  • Structural Basis of Transcription Initiation: RNA Polymerase Holoenzyme at 4 Å Resolution

    Katsuhiko S. Murakami;Shoko Masuda;Seth A. Darst

  • Bacterial RNA polymerases: the wholo story

    Katsuhiko S Murakami;Seth A Darst

  • Bacterial Sigma Factors: A Historical, Structural, and Genomic Perspective

    Andrey Feklístov;Brian D. Sharon;Seth A. Darst;Carol A. Gross

  • A Structural Model of Transcription Elongation

    Nataliya Korzheva;Arkady Mustaev;Maxim Kozlov;Arun Malhotra

  • Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

    James Chen;Brandon Malone;Eliza Llewellyn;Michael Grasso

  • Crystal Structure of a σ70 Subunit Fragment from E. coli RNA Polymerase

    Arun Malhotra;Elena Severinova;Seth A Darst

  • Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein.

    Radhika Subramanian;Elizabeth M. Wilson-Kubalek;Christopher P. Arthur;Matthew J. Bick

  • Catabolite activator protein: DNA binding and transcription activation

    Catherine L Lawson;David Swigon;Katsuhiko S Murakami;Seth A Darst

  • Structural Basis for Promoter −10 Element Recognition by the Bacterial RNA Polymerase σ Subunit

    Andrey Feklistov;Seth A. Darst

  • Crystal Structure of Escherichia coli σE with the Cytoplasmic Domain of Its Anti-σ RseA

    Elizabeth A. Campbell;Jonathan L. Tupy;Tanja M. Gruber;Sheng Wang

  • Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.

    Leonid Minakhin;Sechal Bhagat;Adrian Brunning;Elizabeth A. Campbell

  • Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail.

    Kelly Anne Wilson;Markus Kalkum;Jennifer Ottesen;Julia Yuzenkova

  • THREE-DIMENSIONAL STRUCTURE OF E. COLI CORE RNA POLYMERASE : PROMOTER BINDING AND ELONGATION CONFORMATIONS OF THE ENZYME

    Andrey Polyakov;Elena Severinova;Seth A. Darst

  • Structure and Function of the Transcription Elongation Factor GreB Bound to Bacterial RNA Polymerase

    Natacha Opalka;Mark Chlenov;Pablo Chacon;William J. Rice

  • Molecular Evolution of Multisubunit RNA Polymerases: Sequence Analysis

    William J. Lane;Seth A. Darst

  • Three-dimensional structure of Escherichia coli RNA polymerase holoenzyme determined by electron crystallography.

    Seth A. Darst;Elizabeth W. Kubalek;Roger D. Kornberg

Frequent Co-Authors

Elizabeth A. Campbell
Elizabeth A. Campbell Rockefeller University
Robert Landick
Robert Landick University of Wisconsin–Madison
Konstantin Severinov
Konstantin Severinov Rutgers, The State University of New Jersey
Brian T. Chait
Brian T. Chait Rockefeller University
Ann Hochschild
Ann Hochschild Harvard University
Katsuhiko S. Murakami
Katsuhiko S. Murakami Pennsylvania State University
Michael S. Glickman
Michael S. Glickman Memorial Sloan Kettering Cancer Center
Roger D. Kornberg
Roger D. Kornberg Stanford University
Richard L. Gourse
Richard L. Gourse University of Wisconsin–Madison
Alex Goldfarb
Alex Goldfarb Inozyme Pharma

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring an education in Molecular Biology opens doors to various science and health fields. If you’re interested in understanding human behavior, you may want to consider clinical psychologist online programs. These programs emphasize research skills, lab techniques, and the psychological aspects linked to human biology.

For those seeking to begin their careers quickly, an accelerated human services degree online can be a fast track to entry-level positions that support community health, wellness, and public services.

If you're considering working in communication sciences, understanding the education required to be a speech pathologist is essential. Many SLPs have a strong foundation in biology, anatomy, and human development.

Finally, molecular biology’s analytical skills are valued in design and technology. You might also be interested in the online architecture degree pathway if you enjoy applying biology concepts to innovation in the built environment.

Best Scientists Citing Seth A. Darst

Trending Scientists

Recently Published Articles