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Neuroscience

D-Index
82
Citations
39276
World Ranking
1486
National Ranking
21

Biology and Biochemistry

D-Index
82
Citations
39165
World Ranking
3615
National Ranking
102

Overview

Karl Herrup is affiliated with Hong Kong University of Science and Technology in China. Their research spans several fields, including Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Within these broad areas, they have focused on specialized subfields such as Molecular Biology, Physiology, Cellular and Molecular Neuroscience, Neurology, and Immunology.

Their published work frequently addresses topics related to Alzheimer's disease research and treatments. Additional research interests include DNA repair mechanisms, cholinesterase and neurodegenerative diseases, neurogenesis and neuroplasticity mechanisms, neuroinflammation and neurodegeneration mechanisms, genetic neurodegenerative diseases, and mitochondrial function and pathology.

Herrup has published recent papers in various scientific venues. Notable publications include:

  • ATM loss disrupts the autophagy-lysosomal pathway, 2020, Autophagy
  • Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data, 2024, eNeuro
  • Selective loss of 5hmC promotes neurodegeneration in the mouse model of Alzheimer's disease, 2020, The FASEB Journal
  • The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes, 2023, Journal of Alzheimer s Disease
  • Context-Dependent Functions of E2F1: Cell Cycle, Cell Death, and DNA Damage Repair in Cortical Neurons, 2020, Molecular Neurobiology

Frequent publication venues for Herrup include bioRxiv (Cold Spring Harbor Laboratory), Alzheimer's & Dementia, Ageing Research Reviews, Zenodo (CERN European Organization for Nuclear Research), and eNeuro.

Collaborations appear integral to Herrup's work, with frequent co-authors including Fulin Ma, Kai-Hei Tse, Hei-Man Chow, Kasper P. Kepp, and Gerald Wai-Yeung Cheng.

In addition to journal publications, Herrup has authored a book published by The MIT Press entitled How Not to Study a Disease (2021).

Best Publications

  • Neuroinflammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

  • RAG-1-deficient mice have no mature B and T lymphocytes

    Peter Mombaerts;John Iacomini;Randall Scott Johnson;Karl Herrup

  • Targeted Disruption of Mouse EGF Receptor: Effect of Genetic Background on Mutant Phenotype

    David W. Threadgill;Andrzej A. Dlugosz;Laura A. Hansen;Tamar Tennenbaum

  • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.

    Eva Y.-H. P. Lee;Chi-Yao Chang;Nanpin Hu;Yi-Chun J. Wang

  • Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice.

    Atsu Aiba;Masanobu Kano;Chong Chen;Chong Chen;Mark Stanton

  • The case for rejecting the amyloid cascade hypothesis

    Karl Herrup

  • The control of neuron number.

    Robert W. Williams;Karl Herrup

  • DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease

    Yan Yang;David S. Geldmacher;Karl Herrup

  • Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

    Jonathan Busser;David S. Geldmacher;Karl Herrup

  • Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

    Karl Herrup;Yan Yang

  • Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox.

    AL Joyner;K Herrup;BA Auerbach;CA Davis;CA Davis

  • Neuronal Cell Death Is Preceded by Cell Cycle Events at All Stages of Alzheimer's Disease

    Yan Yang;Elliott J. Mufson;Karl Herrup

  • Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice

    Atsu Aiba;Chong Chen;Chong Chen;Karl Herrup;Christian Rosenmund

  • Social Interaction and Sensorimotor Gating Abnormalities in Mice Lacking Dvl1

    Nardos Lijam;Richard Paylor;Michael P. McDonald;Jacqueline N. Crawley

  • The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

    Hendrik G. Stunnenberg;Martin Hirst

  • Reimagining Alzheimer's Disease—An Age-Based Hypothesis

    Karl Herrup

  • Quantification without pontification: choosing a method for counting objects in sectioned tissues.

    R.W. Guillery;Karl Herrup

  • Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

    Eva Y H P Lee;Nanpin Hu;Shyng Shiou F Yuan;Laura A. Cox

  • Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex

    Edward C. Gilmore;Toshio Ohshima;André M. Goffinet;Ashok B. Kulkarni

  • Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants

    Kathleen Joyce Millen;Wolfgang Wurst;Karl Herrup;Alexandra Joyner

  • Neuroinfl ammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

Frequent Co-Authors

Jie Zhang
Jie Zhang Newcastle University
Bruce T. Lamb
Bruce T. Lamb Indiana University
Jean Mariani
Jean Mariani Sorbonne University
Ronald P. Hart
Ronald P. Hart Rutgers, The State University of New Jersey
Richard Hawkes
Richard Hawkes University of Calgary
Nicole Delhaye-Bouchaud
Nicole Delhaye-Bouchaud Sorbonne University
Richard M. Ransohoff
Richard M. Ransohoff Harvard University
Alexandra L. Joyner
Alexandra L. Joyner Memorial Sloan Kettering Cancer Center
Rachael L. Neve
Rachael L. Neve Harvard University

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