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Immunology
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2026

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Best Scientists

D-Index
199
Citations
130054
World Ranking
307
National Ranking
205

Immunology

D-Index
198
Citations
132512
World Ranking
12
National Ranking
7

Molecular Biology

D-Index
200
Citations
133122
World Ranking
21
National Ranking
14

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2020 - Distinguished Fellows of the American Association of Immunologists (AAI)
  • 2019 - AAI-BioLegend Herzenberg Award, American Association of Immunologists
  • 2015 - Szent-Györgyi Prize for Progress in Cancer Research, National Foundation for Cancer Research (NFCR)
  • 2011 - Member of the National Academy of Medicine (NAM)
  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2004 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 2003 - AAI Excellence in Mentoring Award, American Association of Immunologists
  • 1994 - Member of the National Academy of Sciences
  • 1994 - Fellow of the American Academy of Arts and Sciences

Overview

Frederick W. Alt is affiliated with Boston Children's Hospital in the United States. Their research primarily spans the fields of Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine, with a strong focus on subfields such as Immunology, Molecular Biology, Virology, Radiology, Nuclear Medicine and Imaging, and Infectious Diseases.

The main topics covered in Frederick W. Alt's research include T-cell and B-cell Immunology, Immune Cell Function and Interaction, HIV Research and Treatment, Monoclonal and Polyclonal Antibodies Research, Genomics and Chromatin Dynamics, Immunotherapy and Immune Responses, and DNA Repair Mechanisms.

Frederick W. Alt has contributed to numerous publications in notable scientific venues. These frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Nature, Proceedings of the National Academy of Sciences, Nature Reviews Immunology, and Nature Communications.

Recent papers authored or co-authored by Frederick W. Alt include:

  • Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies, 2022, Nature Reviews Immunology
  • eccDNAs are apoptotic products with high innate immunostimulatory activity, 2021, Nature
  • BCR selection and affinity maturation in Peyer's patch germinal centres, 2020, Nature
  • CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning, 2020, Nature
  • The role of chromatin loop extrusion in antibody diversification, 2022, Nature Reviews Immunology

Frederick W. Alt has collaborated frequently with several researchers, including:

  • Ming Tian
  • Adam Yongxin Ye
  • Barton F. Haynes
  • Kevin O. Saunders
  • Aimee Williams

Their career includes several awards and recognitions such as:

  • Distinguished Fellows of the American Association of Immunologists (AAI), 2020
  • AAI-BioLegend Herzenberg Award, American Association of Immunologists, 2019
  • Szent-Györgyi Prize for Progress in Cancer Research, National Foundation for Cancer Research (NFCR), 2015
  • Member of the National Academy of Medicine (NAM), 2011
  • Fellow of the American Association for the Advancement of Science (AAAS), 2010
  • Robert J. and Claire Pasarow Foundation Medical Research Award, 2004
  • AAI Excellence in Mentoring Award, American Association of Immunologists, 2003
  • Member of the National Academy of Sciences, 1994
  • Fellow of the American Academy of Arts and Sciences, 1994

Best Publications

  • Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

    Anne Brunet;Lora B. Sweeney;J. Fitzhugh Sturgill;Katrin F. Chua

  • RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

    Yoichi Shinkai;Gary Rathbun;Kong-Peng Lam;Eugene M. Oltz

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

    Matthew D. Hirschey;Tadahiro Shimazu;Tadahiro Shimazu;Eric Goetzman;Enxuan Jing

  • An early haematopoietic defect in mice lacking the transcription factor GATA-2.

    Fong-Ying Tsai;Fong-Ying Tsai;Gordon Keller;Frank C. Kuo;Mitchell Weiss

  • A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

    In Hye Lee;Liu Cao;Raul Mostoslavsky;David B. Lombard

  • Plasma cell differentiation requires the transcription factor XBP-1

    Andreas M. Reimold;Neal N. Iwakoshi;John Manis;Prashanth Vallabhajosyula

  • Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

    Zachary Gerhart-Hines;Zachary Gerhart-Hines;Joseph T. Rodgers;Joseph T. Rodgers;Olivia Bare;Carles Lerin;Carles Lerin

  • SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

    Gad Asher;David Gatfield;Markus Stratmann;Hans Reinke

  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

    David B. Lombard;Frederick W. Alt;Hwei Ling Cheng;Jakob Bunkenborg

  • SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

    Marcia C. Haigis;Raul Mostoslavsky;Kevin M. Haigis;Kamau Fahie

  • Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

    Dennis M. Willerford;Jianzhu Chen;Judith A. Ferry;Laurie Davidson

  • Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

    Hwei-Ling Cheng;Raul Mostoslavsky;Shin'ichi Saito;John P. Manis

  • Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

    Merja Lakso;Jose G. Pichel;James R. Gorman;Brian Sauer

  • The Mechanism and Regulation of Chromosomal V(D)J Recombination

    Craig H Bassing;Wojciech Swat;Frederick W Alt

  • DNA Repair, Genome Stability, and Aging

    David B. Lombard;Katrin F. Chua;Raul Mostoslavsky;Sonia Franco

  • Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

    Tracy Blunt;Nicholas J Finnie;Guillermo E Taccioli;Guillermo E Taccioli;Graeme C.M Smith

  • Ordered rearrangement of immunoglobulin heavy chain variable region segments.

    F W Alt;G D Yancopoulos;T K Blackwell;C Wood

  • Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

    Frederick W. Alt;David Baltimore

  • SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

    Philipp Oberdoerffer;Shaday Michan;Michael McVay;Raul Mostoslavsky

Frequent Co-Authors

John P. Manis
John P. Manis Boston Children's Hospital
Laurie Davidson
Laurie Davidson Howard Hughes Medical Institute
Craig H. Bassing
Craig H. Bassing Children's Hospital of Philadelphia
George D. Yancopoulos
George D. Yancopoulos Regeneron (United States)
Raul Mostoslavsky
Raul Mostoslavsky Harvard University
Scott B. Snapper
Scott B. Snapper Boston Children's Hospital
Ronald A. DePinho
Ronald A. DePinho The University of Texas MD Anderson Cancer Center
Wojciech Swat
Wojciech Swat Washington University in St. Louis
Jo Ann Sekiguchi
Jo Ann Sekiguchi University of Michigan–Ann Arbor
David B. Lombard
David B. Lombard University of Michigan–Ann Arbor

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