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Molecular Biology

D-Index
51
Citations
12777
World Ranking
2483
National Ranking
1226

Overview

Jo Ann Sekiguchi is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with specific focus on Molecular Biology, Oncology, Public Health, Environmental and Occupational Health, Immunology, and Cancer Research.

The primary research topics addressed by Sekiguchi include:

  • DNA Repair Mechanisms
  • Epigenetics and DNA Methylation
  • Acute Lymphoblastic Leukemia research
  • RNA modifications and cancer
  • Cancer-related Molecular Pathways
  • Carcinogens and Genotoxicity Assessment
  • Immune Response and Inflammation

Selected recent research papers authored by Sekiguchi include:

  • Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress, 2023, Blood
  • Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease, 2021, Scientific Reports
  • Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder, 2024, Human Molecular Genetics
  • Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress, 2023, bioRxiv (Cold Spring Harbor Laboratory)
  • Editorial: Interplay between oncomicrobes, the microbiota and the immune system: impact on responses to cancer immunotherapy, 2023, Frontiers in Immunology

Frequent co-authors in their work include:

  • Andrea J. Hartlerode
  • Ahmed Mostafa
  • S Orbán
  • David O Ferguson
  • Ashley F. Melnick

Common publication venues for Sekiguchi's research are:

  • Human Molecular Genetics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Scientific Reports
  • Frontiers in Immunology

Best Publications

  • Essential Bacillus subtilis genes

    K. Kobayashi;S.D. Ehrlich;A. Albertini;G. Amati

  • Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

    Yijie Gao;David O. Ferguson;David O. Ferguson;Wei Xie;John P. Manis

  • A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis

    Yijie Gao;Yi Sun;Karen M. Frank;Pieter Dikkes

  • Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

    Craig H. Bassing;Katrin F. Chua;Jo Ann Sekiguchi;Heikyung Suh

  • Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV.

    Karen M. Frank;Joann M. Sekiguchi;Katherine J. Seidl;Wojciech Swat

  • DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

    Karen M. Frank;Norman E. Sharpless;Yijie Gao;Jo Ann M. Sekiguchi

  • Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

    Yansong Gu;Katherine J. Seidl;Gary A. Rathbun;Chengming Zhu

  • The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.

    David O. Ferguson;JoAnn M. Sekiguchi;Sandy Chang;Karen M. Frank

  • Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

    Moumita Chaki;Rannar Airik;Amiya K. Ghosh;Rachel H. Giles

  • Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

    Jeffrey Buis;Yipin Wu;Yibin Deng;Jennifer Leddon

  • Leaky Scid Phenotype Associated with Defective V(D)J Coding End Processing in Artemis-Deficient Mice

    Sean Rooney;Jo Ann Sekiguchi;Chengming Zhu;Hwei Ling Cheng

  • Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.

    Yansong Gu;JoAnn Sekiguchi;Yijie Gao;Pieter Dikkes

  • Multiple functions of MRN in end-joining pathways during isotype class switching.

    Maria Dinkelmann;Elizabeth Spehalski;Trina Stoneham;Jeffrey Buis

  • Site-specific ribonuclease activity of eukaryotic DNA topoisomerase I.

    Jo Ann Sekiguchi;Stewart Shuman

  • RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues.

    Robert J. Monroe;Katherine J. Seidl;Frank Gaertner;Shuhua Han

  • Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres

    Tammy A. Morrish;Jose Luis Garcia-Perez;Thomas D. Stamato;Guillermo E. Taccioli

  • Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells

    Sean Rooney;Frederick W. Alt;David Lombard;David Lombard;Scott Whitlow

  • Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

    JoAnn Sekiguchi;David O. Ferguson;Hua Tang Chen;Eva Mary Yang

  • Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4

    Peï Yu Wu;Philippe Frit;Philippe Frit;Srilakshmi Meesala;Stéphanie Dauvillier;Stéphanie Dauvillier

  • Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells

    Sean Rooney;Jo Ann Sekiguchi;Scott Whitlow;Mark Eckersdorff

Frequent Co-Authors

Stewart Shuman
Stewart Shuman Memorial Sloan Kettering Cancer Center
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
John P. Manis
John P. Manis Boston Children's Hospital
Jolan E. Walter
Jolan E. Walter University of South Florida
Laurie Davidson
Laurie Davidson Howard Hughes Medical Institute
Eric B. Kmiec
Eric B. Kmiec University of Delaware
David G. Schatz
David G. Schatz Yale University
Ronald A. DePinho
Ronald A. DePinho The University of Texas MD Anderson Cancer Center
David B. Lombard
David B. Lombard University of Michigan–Ann Arbor
Pietro Luigi Poliani
Pietro Luigi Poliani University of Brescia

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