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Molecular Biology

D-Index
72
Citations
20287
World Ranking
1313
National Ranking
98

Overview

George Iliakis is affiliated with the University of Duisburg-Essen in Germany and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their scholarly output includes 71 publications in biochemistry-related disciplines and 28 in medicine.

Their work extends into several subfields, with the majority focusing on Molecular Biology, Oncology, and Cancer Research. Additional subfields include Plant Science and Pulmonary and Respiratory Medicine.

The main research topics covered in Iliakis's work encompass:

  • DNA Repair Mechanisms
  • PARP inhibition in cancer therapy
  • Carcinogens and Genotoxicity Assessment
  • Plant Genetic and Mutation Studies
  • CRISPR and Genetic Engineering
  • Cell death mechanisms and regulation
  • Radiation Therapy and Dosimetry

They have published several recent papers including:

  • "Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond," 2020, NAR Cancer
  • "DNA Damage Clustering after Ionizing Radiation and Consequences in the Processing of Chromatin Breaks," 2022, Molecules
  • "Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types," 2021, Science Translational Medicine
  • "Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells," 2022, Journal of Experimental & Clinical Cancer Research
  • "New Facets of DNA Double Strand Break Repair: Radiation Dose as Key Determinant of HR versus c-NHEJ Engagement," 2023, International Journal of Molecular Sciences

Frequent collaborators of George Iliakis include Martin Stuschke, Emil Mladenov, Aashish Soni, Veronika Mladenova, and Fanghua Li. These partnerships reflect ongoing research contributions and co-authorship in multiple publications.

Preferred publication venues for Iliakis are:

  • International Journal of Molecular Sciences
  • Cells
  • Cancers
  • DNA repair
  • Nucleic Acids Research

Best Publications

  • γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

    Andrea Kinner;Wenqi Wu;Christian Staudt;George Iliakis

  • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

    Minli Wang;Weizhong Wu;Wenqi Wu;Bustanur Rosidi

  • DNA damage checkpoint control in cells exposed to ionizing radiation.

    George Iliakis;Ya Wang;Jun Guan;Huichen Wang

  • Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways.

    Emil Mladenov;George Iliakis

  • Mechanisms of DNA double strand break repair and chromosome aberration formation.

    G Iliakis;H Wang;A R Perrault;W Boecker

  • Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

    Lorenzo Costantino;Sotirios K. Sotiriou;Juha K. Rantala;Simon Magin

  • DNA Ligase III as a Candidate Component of Backup Pathways of Nonhomologous End Joining

    Huichen Wang;Bustanur Rosidi;Ronel Perrault;Minli Wang

  • hTERT associates with human telomeres and enhances genomic stability and DNA repair

    Girdhar G Sharma;Girdhar G Sharma;Arun Gupta;Arun Gupta;Huichen Wang;Harry Scherthan

  • Biochemical evidence for Ku‐independent backup pathways of NHEJ

    Huichen Wang;Ange Ronel Perrault;Yoshihiko Takeda;Wei Qin

  • DNA double-strand–break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice

    Agnes Schipler;George Iliakis

  • Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

    Fen Xia;Danielle G. Taghian;Jeffrey S. DeFrank;Zhao-Chong Zeng

  • DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus.

    Steven J. DiBiase;Zhao-Chong Zeng;Richard Chen;Terry Hyslop

  • DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.

    Emil Mladenov;Simon Magin;Aashish Soni;George Iliakis

  • Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

    Honghai Ouyang;Andre Nussenzweig;Akihiro Kurimasa;Vera Da Costa Soares

  • DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation.

    Emil Mladenov;Simon Magin;Aashish Soni;George Iliakis

  • Results of a Pilot Study Involving the Use of an Antisense Oligodeoxynucleotide Directed Against the Insulin-Like Growth Factor Type I Receptor in Malignant Astrocytomas

    David W. Andrews;Mariana Resnicoff;Adam E. Flanders;Lawrence Kenyon

  • Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors

    Hongyan Wang;Minli Wang;Huichen Wang;Wilfried Böcker

  • Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence

    George Iliakis

  • Measurement of DNA double-strand breaks in CHO cells at various stages of the cell cycle using pulsed field gel electrophoresis: calibration by means of 125I decay.

    G.E. Iliakis;O. Cicilioni;L. Metzger

  • Cyclin B expression in HeLa cells during the G2 block induced by ionizing radiation.

    Ruth J. Muschel;Hong Bing Zhang;George Iliakis;W. Gillies McKenna

Frequent Co-Authors

Walter J. Curran
Walter J. Curran Emory University
Gloria C. Li
Gloria C. Li Memorial Sloan Kettering Cancer Center
Alexandros G. Georgakilas
Alexandros G. Georgakilas National Technical University of Athens
Verena Jendrossek
Verena Jendrossek University of Duisburg-Essen
David J. Chen
David J. Chen The University of Texas Southwestern Medical Center
Carmel Mothersill
Carmel Mothersill McMaster University
Simon N. Powell
Simon N. Powell Memorial Sloan Kettering Cancer Center
David W. Andrews
David W. Andrews Sunnybrook Health Science Centre
Tej K. Pandita
Tej K. Pandita Houston Methodist
Renato Baserga
Renato Baserga Thomas Jefferson University

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