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Molecular Biology

D-Index
81
Citations
23051
World Ranking
966
National Ranking
514

Overview

Simon N. Powell is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a strong focus on Molecular Biology, Cancer Research, Oncology, Pulmonary and Respiratory Medicine, and Genetics.

The scientist's work covers a range of topics, including:

  • Breast Cancer Treatment Studies
  • DNA Repair Mechanisms
  • Advanced Radiotherapy Techniques
  • Cancer Genomics and Diagnostics
  • BRCA gene mutations in cancer
  • Breast Lesions and Carcinomas
  • Breast Implant and Reconstruction

Among their recent publications are:

  • Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs, 2020, Cell
  • Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis, 2020, Cancer Discovery
  • Non-cell-autonomous cancer progression from chromosomal instability, 2023, Nature
  • Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection, 2020, Clinical Cancer Research
  • Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy, 2020, Nature Cancer

Frequent co-authors in their publications include:

  • Atif J. Khan
  • Lior Z. Braunstein
  • Nadeem Riaz
  • Beryl McCormick
  • Jorge S. Reis-Filho

Simon N. Powell's research has been published extensively in a variety of scientific journals. The most common publication venues are:

  • International Journal of Radiation Oncology*Biology*Physics
  • Cancer Research
  • Journal of Clinical Oncology
  • Advances in Radiation Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • BRCA1 and BRCA2: different roles in a common pathway of genome protection

    Unknown

  • Chromosomal instability drives metastasis through a cytosolic DNA response.

    Samuel F. Bakhoum;Samuel F. Bakhoum;Bryan Ngo;Ashley M. Laughney;Julie Ann Cavallo;Julie Ann Cavallo

  • The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

    Matthew Bott;Marie Brevet;Barry S Taylor;Shigeki Shimizu

  • Androgen receptor signaling regulates DNA repair in prostate cancers

    William R. Polkinghorn;Joel S. Parker;Man X. Lee;Elizabeth M. Kass

  • Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation.

    Unknown

  • BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

    Rachel Litman;Min Peng;Zhe Jin;Fan Zhang

  • Differential Sensitivity of p53(-) and p53(+) Cells to Caffeine-induced Radiosensitization and Override of G2 Delay

    Simon N. Powell;Jeffrey S. DeFrank;Paul Connell;Maeve Eogan

  • Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

    Unknown

  • A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer.

    Xiaoxia Hu;Dusten M. Macdonald;Phyllis C. Huettner;Zhihui Feng

  • Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance

    Norman Chan;Marianne Koritzinsky;Helen Zhao;Helen Zhao;Ranjit Bindra

  • Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

    Fen Xia;Danielle G. Taghian;Jeffrey S. DeFrank;Zhao-Chong Zeng

  • Inactivation of p53 results in high rates of homologous recombination

    Unknown

  • Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs.

    Kevin Hadi;Xiaotong Yao;Julie M. Behr;Aditya Deshpande

  • Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.

    Unknown

  • RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination.

    Unknown

  • Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes

    Nadeem Riaz;Pedro Blecua;Raymond S. Lim;Ronglai Shen

  • BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

    Megan Fabbro;Kienan Savage;Kienan Savage;Karen Hobson;Andrew J. Deans

  • The therapeutic significance of mutational signatures from DNA repair deficiency in cancer

    Jennifer Ma;Jeremy Setton;Nancy Y. Lee;Nadeem Riaz

  • Repair of radiation damage to DNA.

    Unknown

  • Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

    Huichen Wang;Zhao-Chong Zeng;Tu-Anh Bui;Steven J. DiBiase

Frequent Co-Authors

Alphonse G. Taghian
Alphonse G. Taghian Harvard University
Monica Morrow
Monica Morrow Memorial Sloan Kettering Cancer Center
Barbara L. Smith
Barbara L. Smith Harvard University
Abram Recht
Abram Recht Beth Israel Deaconess Medical Center
Jorge S. Reis-Filho
Jorge S. Reis-Filho Memorial Sloan Kettering Cancer Center
Zvi Fuks
Zvi Fuks Memorial Sloan Kettering Cancer Center
Nancy Y. Lee
Nancy Y. Lee Memorial Sloan Kettering Cancer Center
Mark E. Robson
Mark E. Robson Memorial Sloan Kettering Cancer Center
Clifford A. Hudis
Clifford A. Hudis Memorial Sloan Kettering Cancer Center
Reshma Jagsi
Reshma Jagsi University of Michigan–Ann Arbor

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