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Patrício Soares-da-Silva

Patrício Soares-da-Silva

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
15582
World Ranking
8670
National Ranking
33

Medicine

D-Index
70
Citations
17356
World Ranking
20103
National Ranking
18

Overview

Patrício Soares-da-Silva is affiliated with Bial in Portugal and has contributed extensively to the field of medicine, with a particular focus on neurology. Their work spans 175 publications concentrated mainly in neurology, psychiatry and mental health, pharmacology, cellular and molecular neuroscience, and molecular biology.

The scientist's research primarily addresses neurological disorders and treatments. Key topics in their body of work include Parkinson's disease mechanisms and treatments, neurological disorders and treatments, botulinum toxin and related neurological disorders, neuroscience and neuropharmacology research, epilepsy research and treatment, attention deficit hyperactivity disorder, and eicosanoids and hypertension pharmacology.

Frequent publication venues for this researcher include:

  • Journal of the Neurological Sciences
  • Parkinsonism & Related Disorders
  • Neurology
  • CHEST Journal
  • Translational Neurodegeneration

Notable recent papers are:

  • Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: the OPTIPARK open-label study, 2020, Translational Neurodegeneration
  • Redefining the strategy for the use of COMT inhibitors in Parkinson's disease: the role of opicapone, 2021, Expert Review of Neurotherapeutics
  • Efficacy and safety of eslicarbazepine acetate as adjunctive therapy for refractory focal-onset seizures in children: A double-blind, randomized, placebo-controlled, parallel-group, multicenter, phase-III clinical trial, 2020, Epilepsy & Behavior
  • Liver says no: the ongoing search for safe catechol O-methyltransferase inhibitors to replace tolcapone, 2020, Drug Discovery Today
  • Effect of Opicapone on Levodopa Pharmacokinetics in Patients with Fluctuating Parkinson's Disease, 2022, Movement Disorders

Frequent coauthors collaborating with Patrício Soares-da-Silva include:

  • José Rocha
  • Diogo Magalhães
  • Joaquim J. Ferreira
  • Andrew J. Lees
  • José-Francisco Rocha

Best Publications

  • Pharmacokinetic and safety profile of trans‐resveratrol in a rising multiple‐dose study in healthy volunteers

    Luis Almeida;Manuel Vaz-da-Silva;Amílcar Falcão;Eva Soares

  • Mechanisms of Action of Carbamazepine and Its Derivatives, Oxcarbazepine, BIA 2-093, and BIA 2-024*

    António F. Ambrósio;Patrício Soares-da-Silva;Caetana M. Carvalho;Arsélio P. Carvalho

  • Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures : A randomized, double-blind, placebo-controlled, parallel-group phase III study

    Christian Elger;Peter Halász;Joana Maia;Luis Almeida

  • Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.

    Jan Benes;António Parada;Anabela A. Figueiredo;Paula C. Alves

  • Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial

    Joaquim J Ferreira;Andrew Lees;José-Francisco Rocha;Werner Poewe

  • Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.

    Maria João Bonifácio;P. Nuno Palma;Luís Almeida;Luís Almeida;Patrício Soares-da-Silva;Patrício Soares-da-Silva

  • Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5-hydroxytryptamine in human inflammatory bowel disease.

    F Magro;M A Vieira-Coelho;S Fraga;M P Serrão

  • Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells (Journal of Clinical Investigation (2008) 118, (2180-2189) DOI: 10.1172/JCI33637)

    Hewang Li;Ines Armando;Peiying Yu;Crisanto Escano

  • Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy.

    E. Ben-Menachem;A.A. Gabbai;A. Hufnagel;J. Maia

  • Eslicarbazepine acetate (BIA 2-093).

    Luis Almeida;Patrício Soares-da-Silva

  • Pharmacokinetics and drug interactions of eslicarbazepine acetate

    Meir Bialer;Patricio Soares-da-Silva;Patricio Soares-da-Silva

  • Discovery of a Long-Acting, Peripherally Selective Inhibitor of Catechol-O-methyltransferase

    László E. Kiss;Humberto S. Ferreira;Leonel Torrão;Maria João Bonifácio

  • Efficacy and safety of 800 and 1200 mg eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures.

    A. Gil-Nagel;J. Lopes-Lima;L. Almeida;L. Almeida;J. Maia

  • Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine

    R Pedrosa;P Soares-da-Silva

  • Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive

    Tom R. Hollon;Martin J. Bek;Jean E. Lachowicz;Marjorie A. Ariano

  • Eslicarbazepine Acetate: A Double-blind, Add-on, Placebo-controlled Exploratory Trial in Adult Patients with Partial-onset Seizures

    Christian Elger;Meir Bialer;Joyce A. Cramer;Joana Maia

  • Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial

    Andrew J Lees;Joaquim Ferreira;Olivier Rascol;Werner Poewe

  • Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial-onset seizures: Results of a phase III, double-blind, randomized, placebo-controlled trial.

    Michael R. Sperling;Bassel Abou-Khalil;Jay Harvey;Joanne B. Rogin

  • Metabolism of two new antiepileptic drugs and their principal metabolites S(+)- and R(-)-10,11-dihydro-10-hydroxy carbamazepine.

    Dominik Hainzl;António Parada;Patrı́cio Soares-da-Silva

  • Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels : Comparison with carbamazepine

    M. J. Bonifácio;R. D. Sheridan;A. Parada;R. A. Cunha

Frequent Co-Authors

Luís Pereira de Almeida
Luís Pereira de Almeida University of Coimbra
Luis Almeida
Luis Almeida University of Porto
Andrew J. Lees
Andrew J. Lees University College London
Pedro A. Jose
Pedro A. Jose George Washington University
Werner Poewe
Werner Poewe Innsbruck Medical University
Maria Helena Fernandes
Maria Helena Fernandes University of Porto
Olivier Rascol
Olivier Rascol Federal University of Toulouse Midi-Pyrénées
Christian E. Elger
Christian E. Elger University Hospital Bonn
Elinor Ben-Menachem
Elinor Ben-Menachem University of Gothenburg
Maria Arménia Carrondo
Maria Arménia Carrondo Universidade Nova de Lisboa

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