World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
16216
World Ranking
7431
National Ranking
3389

Research.com Recognitions

  • 2020 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Wendy B. Macklin is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research spans various areas within neuroscience, biochemistry, genetics, molecular biology, and medicine, reflecting interdisciplinary expertise. The scientist's work primarily focuses on developmental neuroscience, neurology, molecular biology, immunology, and cell biology.

The main topics covered in their research include neurogenesis and neuroplasticity mechanisms, neuroinflammation and neurodegeneration mechanisms, microRNA in disease regulation, immune cells in cancer, zebrafish biomedical research applications, olfactory and sensory function studies, and gastrointestinal motility and disorders.

Their recent publications demonstrate a focus on neural and cellular mechanisms as well as metabolic processes. Notable recent papers include:

  • "Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia" (2021) published in Microbiome
  • "Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence" (2021) published in Cell Reports
  • "Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord" (2022) published in Cell Reports
  • "Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination" (2020) published in Journal of Neuroscience
  • "Intrinsic and extrinsic regulators of oligodendrocyte progenitor proliferation and differentiation" (2020) published in Seminars in Cell and Developmental Biology

Collaboration is a key component of their work, with frequent co-authors including Teresa L. Wood, Katherine S. Given, Jennifer N. Bourne, Diego Restrepo, and Luipa Khandker. These partnerships have contributed to a body of work published across multiple venues.

Macklin's publications appear frequently in journals and preprint servers such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Neuroscience, Glia, Cell Reports, and Journal of Neuroscience Research. These outlets reflect the scientist's ongoing engagement with neuroscience and related biomedical fields.

The scientist has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2020, acknowledging their contributions within the scientific community.

Best Publications

  • Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

    Ranjan Dutta;Jennifer McDonough;Xinghua Yin;John Peterson

  • Bace1 modulates myelination in the central and peripheral nervous system

    Xiangyou Hu;Caitlin W Hicks;Wanxia He;Philip Wong

  • Differentiation and death of premyelinating oligodendrocytes in developing rodent brain.

    Bruce D. Trapp;Akiko Nishiyama;David Cheng;Wendy Macklin

  • Proteolipid Promoter Activity Distinguishes Two Populations of NG2-Positive Cells throughout Neonatal Cortical Development

    Barbara S. Mallon;H. Elizabeth Shick;Grahame J. Kidd;Wendy B. Macklin

  • Constitutively Active Akt Induces Enhanced Myelination in the CNS

    Ana I. Flores;S. Priyadarshini Narayanan;Emily N. Morse;H. Elizabeth Shick

  • Neurofascins are required to establish axonal domains for saltatory conduction.

    Diane L. Sherman;Steven Tait;Shona Melrose;Richard Johnson

  • Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells

    Dino P Leone;S.téphane Genoud;Suzana Atanasoski;Reinhard Grausenburger

  • Multiple Restricted Origin of Oligodendrocytes

    N. Spassky;C. Goujet-Zalc;E. Parmantier;C. Olivier

  • Dynamics and Mechanisms of CNS Myelination

    Kathryn K. Bercury;Wendy B. Macklin

  • Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.

    S. Priyadarshini Narayanan;Ana I. Flores;Ana I. Flores;Feng Wang;Wendy B. Macklin;Wendy B. Macklin

  • Inducible site-specific recombination in myelinating cells.

    Nathalie H. Doerflinger;Wendy B. Macklin;Brian Popko

  • Hyperphosphorylation and insolubility of α‐synuclein in transgenic mouse oligodendrocytes

    Philipp J Kahle;Manuela Neumann;Laurence Ozmen;Veronika Müller

  • Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum

    Liomar das Neves;Cynthia S. Duchala;Fatima Godinho;Musa A. Haxhiu

  • Cellular and molecular aspects of myelin protein gene expression.

    Anthony T. Campagnoni;Wendy B. Macklin

  • The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties.

    Peter Dy;Alfredo Penzo-Méndez;Hongzhe Wang;Carlos E. Pedraza

  • Glutamate Stimulates Oligodendrocyte Progenitor Migration Mediated via an αv Integrin/Myelin Proteolipid Protein Complex

    Tatyana I. Gudz;Hitoshi Komuro;Wendy B. Macklin

  • Climbing fiber innervation of NG2-expressing glia in the mammalian cerebellum

    Shih Chun Lin;Jojanneke H.J. Huck;J. David B. Roberts;Wendy B. Macklin

  • Akt-Mediated Survival of Oligodendrocytes Induced by Neuregulins

    Ana I. Flores;Barbara S. Mallon;Takashi Matsui;Wataru Ogawa

  • Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

    Xiangyou Hu;Wanxia He;Claudiu Diaconu;Xiaoying Tang

  • A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation.

    Lihong Zhao;Stefka D. Spassieva;Thomas J. Jucius;Leonard D. Shultz

Frequent Co-Authors

Paco S. Herson
Paco S. Herson University of Colorado Denver
Bruce D. Trapp
Bruce D. Trapp Cleveland Clinic Lerner College of Medicine
Diego Restrepo
Diego Restrepo University of Colorado Anschutz Medical Campus
Cornelia C. Bergmann
Cornelia C. Bergmann Cleveland Clinic
Stephen A. Stohlman
Stephen A. Stohlman Cleveland Clinic
Grahame J. Kidd
Grahame J. Kidd Cleveland Clinic
Kazuhiro Ikenaka
Kazuhiro Ikenaka National Institutes of Natural Sciences
Neal S. Peachey
Neal S. Peachey Cleveland Clinic
Anthony T. Campagnoni
Anthony T. Campagnoni University of California, Los Angeles
David R. Hinton
David R. Hinton University of Southern California

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