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Neuroscience

D-Index
63
Citations
11617
World Ranking
3438
National Ranking
311

Research.com Recognitions

  • 2007 - Fellow of the Royal Society of Edinburgh

Overview

Peter J. Brophy is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily focuses on neuroscience and biochemistry, genetics, and molecular biology.

Their recent published work includes studies in various journals such as Science, eLife, Developmental Cell, and Cell Reports. Notable recent papers are:

  • Astrocyte Ca 2+-evoked ATP release regulates myelinated axon excitability and conduction speed, 2021, Science
  • Proteome profile of peripheral myelin in healthy mice and in a neuropathy model, 2020, eLife
  • Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome, 2020, Cell Reports
  • iPSC-derived myelinoids to study myelin biology of humans, 2021, Developmental Cell
  • Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment, 2020, eLife

The scientist has contributed to fields such as:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology

Subfields within their work include:

  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Neurology
  • Developmental Neuroscience
  • Molecular Biology

The main research topics covered in their publications are:

  • Neurogenesis and neuroplasticity mechanisms
  • Microtubule and mitosis dynamics
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Hereditary Neurological Disorders
  • Nerve injury and regeneration
  • Neuroscience and Neuropharmacology Research
  • Caveolin-1 and cellular processes

Frequent co-authors include:

  • Diane L. Sherman
  • Owen G. James
  • Bhuvaneish T. Selvaraj
  • Dario Magnani
  • Karen Burr

Peter J. Brophy has published multiple papers in leading venues, with the highest number of publications appearing in eLife, followed by Developmental Cell, Science, Cell Reports, and the Journal of the Peripheral Nervous System.

The scientist was recognized as a Fellow of the Royal Society of Edinburgh in 2007.

Best Publications

  • Mechanisms of axon ensheathment and myelin growth.

    Diane L. Sherman;Peter J. Brophy

  • Neurofascins are required to establish axonal domains for saltatory conduction.

    Diane L. Sherman;Steven Tait;Shona Melrose;Richard Johnson

  • An Oligodendrocyte Cell Adhesion Molecule at the Site of Assembly of the Paranodal Axo-Glial Junction

    Steven Tait;Frank Gunn-Moore;J. Martin Collinson;Jeffery Huang

  • Neurofascin Is a Glial Receptor for the Paranodin/Caspr-Contactin Axonal Complex at the Axoglial Junction

    Perrine Charles;Steven Tait;Catherine Faivre-Sarrailh;Gilles Barbin

  • Protein zero of peripheral nerve myelin: Biosynthesis, membrane insertion, and evidence for homotypic interaction

    Unknown

  • Unique Role of Dystroglycan in Peripheral Nerve Myelination, Nodal Structure, and Sodium Channel Stabilization

    Fumiaki Saito;Steven A Moore;Rita Barresi;Michael D Henry

  • Peripheral Demyelination and Neuropathic Pain Behavior in Periaxin-Deficient Mice

    C.Stewart Gillespie;Diane L. Sherman;Susan M. Fleetwood-Walker;David F. Cottrell

  • Molecular domains of myelinated axons in the peripheral nervous system

    James L. Salzer;Peter J. Brophy;Elior Peles

  • Specific Disruption of a Schwann Cell Dystrophin-Related Protein Complex in a Demyelinating Neuropathy

    Diane L Sherman;Cinzia Fabrizi;C.Stewart Gillespie;Peter J Brophy

  • Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system.

    Barbara Zonta;Steven Tait;Shona Melrose;Heather Anderson

  • Activated Microglia Mediate Axoglial Disruption That Contributes to Axonal Injury in Multiple Sclerosis

    Owain W. Howell;Jon L. Rundle;Anurag Garg;Masayuki Komada

  • A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot–Marie–Tooth disease

    Angèle Guilbot;Anna Williams;Nicole Ravisé;Christophe Verny

  • Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene

    Armin Schneider;Paul Montague;Paul Montague;Ian Griffiths;Monica Fanarraga

  • Novel E-cadherin-mediated adhesion in peripheral nerve: Schwann cell architecture is stabilized by autotypic adherens junctions [published erratum appears in J Cell Biol 1995 Jun;129(6):1721]

    Unknown

  • Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis.

    O W Howell;A Palser;A Polito;S Melrose

  • Periaxin, a novel protein of myelinating schwann cells with a possible role in axonal ensheathment

    Unknown

  • A glial signal consisting of Gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier

    Konstantin Feinberg;Yael Eshed-Eisenbach;Shahar Frechter;Veronique Amor

  • Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves

    Felipe A. Court;Diane L. Sherman;Thomas Pratt;Emer M. Garry

  • Focal Lysolecithin-Induced Demyelination of Peripheral Afferents Results in Neuropathic Pain Behavior That Is Attenuated by Cannabinoids

    Victoria C. J. Wallace;David F. Cottrell;Peter J. Brophy;Susan M. Fleetwood-Walker

  • Periaxin expression in myelinating Schwann cells : Modulation by axon-glial interactions and polarized localization during development

    Steven S. Scherer;Yi-tian Xu;Peter G. C. Bannerman;Diane L. Sherman

  • Role for the oligodendrocyte cytoskeleton in myelination

    Unknown

  • A Critical Role for Neurofascin in Regulating Action Potential Initiation through Maintenance of the Axon Initial Segment

    Barbara Zonta;Anne Desmazieres;Arianna Rinaldi;Steven Tait

  • Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR

    Diane L Sherman;Michiel Krols;Lai-Man N Wu;Matthew Grove

  • FAK is required for axonal sorting by Schwann cells

    Matthew Grove;Noboru H. Komiyama;Klaus-Armin Nave;Seth G. Grant

  • Rapid Disruption of Axon–Glial Integrity in Response to Mild Cerebral Hypoperfusion

    Michell Mario Reimer;Jamie McQueen;Luke Searcy;Gillian Scullion

  • Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development

    Takeshi Sakurai;Marc Lustig;Joanne Babiarz;Andrew J.W. Furley

  • Periaxin mutations cause a broad spectrum of demyelinating neuropathies

    Hiroshi Takashima;Cornelius F. Boerkoel;Peter De Jonghe;Chantal Ceuterick

Frequent Co-Authors

Matthew N. Rasband
Matthew N. Rasband Baylor College of Medicine
Richard R. Ribchester
Richard R. Ribchester University of Edinburgh
Seth G. N. Grant
Seth G. N. Grant University of Edinburgh
Klaus-Armin Nave
Klaus-Armin Nave Max Planck Society
Susan M. Fleetwood-Walker
Susan M. Fleetwood-Walker University of Edinburgh
Felipe A. Court
Felipe A. Court Buck Institute for Research on Aging
Jeffrey L. Dupree
Jeffrey L. Dupree Virginia Commonwealth University
Peter De Jonghe
Peter De Jonghe University of Antwerp
Vincent Timmerman
Vincent Timmerman University of Antwerp
James R. Lupski
James R. Lupski Baylor College of Medicine

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