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Neuroscience

D-Index
55
Citations
10828
World Ranking
4717
National Ranking
2128

Overview

Jeffrey L. Dupree is affiliated with Virginia Commonwealth University in the United States. Their research spans multiple fields within neuroscience, biochemistry, genetics, molecular biology, and medicine, with a significant emphasis on molecular biology and developmental neuroscience.

Dupree's work primarily focuses on neurogenesis and neuroplasticity mechanisms, neuroinflammation and neurodegeneration mechanisms, and sphingolipid metabolism and signaling. Key areas of investigation also include Alzheimer's disease research and treatments, multiple sclerosis research studies, microRNA in disease regulation, as well as RNA research and splicing.

The scientist's frequent publication venues reflect the interdisciplinary nature of their research. They have contributed multiple papers to UNC Libraries, bioRxiv (Cold Spring Harbor Laboratory), ASN NEURO, the International Journal of Molecular Sciences, and Glia.

Notable recent papers authored or co-authored by Dupree include:

  • Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment, 2021, Molecular Neurodegeneration
  • Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery, 2020, Nature Communications
  • Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes, 2020, JCI Insight
  • Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes, 2021, Neuropsychopharmacology
  • Prolonged Environmental Enrichment Promotes Developmental Myelination, 2021, Frontiers in Cell and Developmental Biology

Frequently collaborating with other researchers, Dupree has worked with Xianlin Han, Shulan Qiu, Juan Pablo Palavicini, Sijia He, and Hu Wang. These collaborations have contributed to a breadth of research outcomes within the main fields and specialized topics Dupree investigates.

Best Publications

  • Impaired adult myelination in the prefrontal cortex of socially isolated mice.

    Jia Liu;Karen Dietz;Jacqueline M DeLoyht;Xiomara Pedre

  • Myelination in the Absence of Galactocerebroside and Sulfatide: Normal Structure with Abnormal Function and Regional Instability

    Timothy Coetzee;Nobuya Fujita;Jeffrey Dupree;Riyi Shi

  • Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

    Siming Shen;Juan Sandoval;Victoria A Swiss;Jiadong Li

  • A functional role for EGFR signaling in myelination and remyelination

    Adan Aguirre;Jeff L Dupree;J M Mangin;Vittorio Gallo

  • Paranodal junction formation and spermatogenesis require sulfoglycolipids.

    Koichi Honke;Yukie Hirahara;Jeffrey Dupree;Kinuko Suzuki

  • Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

    Mar Gacias;Sevasti Gaspari;Patricia-Mae G Santos;Sabrina Tamburini

  • The Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation

    Ye He;Jeff Dupree;Ju Wang;Juan Sandoval

  • Axo-Glial Interactions Regulate the Localization of Axonal Paranodal Proteins

    Jeffrey L. Dupree;Jean-Antoine Girault;Brian Popko

  • Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice.

    Jia Liu;Jeffrey L. Dupree;Mar Gacias;Rebecca Frawley

  • Sulfatide is essential for the maintenance of CNS myelin and axon structure.

    J. Marcus;S. Honigbaum;S. Shroff;K. Honke

  • Myelin galactolipids are essential for proper node of Ranvier formation in the CNS

    Jeffrey L. Dupree;Timothy Coetzee;Andrew Blight;Kinuko Suzuki

  • Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon--glial interactions

    Tadashi Yamashita;Yun-Ping Wu;Roger Sandhoff;Norbert Werth

  • A Myelin Galactolipid, Sulfatide, Is Essential for Maintenance of Ion Channels on Myelinated Axon But Not Essential for Initial Cluster Formation

    Tomoko Ishibashi;Jeffrey L. Dupree;Kazuhiro Ikenaka;Yukie Hirahara

  • Interferon-γ inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

    Wensheng Lin;April Kemper;Jeffrey L. Dupree;Heather P. Harding

  • Spatiotemporal Ablation of Myelinating Glia-Specific Neurofascin (NfascNF155) in Mice Reveals Gradual Loss of Paranodal Axoglial Junctions and Concomitant Disorganization of Axonal Domains

    Anilkumar M. Pillai;Courtney Thaxton;Alaine L. Pribisko;Jr-Gang Cheng

  • GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury

    Marzieh Zonouzi;Joseph Scafidi;Peijun Li;Brian McEllin

  • The effects of interferon-gamma on the central nervous system.

    Brian Popko;Joshua G. Corbin;Kristine D. Baerwald;Jeffrey Dupree

  • Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

    Timothy R. Hammond;Timothy R. Hammond;Ana Gadea;Jeff Dupree;Christophe Kerninon

  • A glial signal consisting of Gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier

    Konstantin Feinberg;Yael Eshed-Eisenbach;Shahar Frechter;Veronique Amor

  • Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions.

    Jill Marcus;Jeffrey L. Dupree;Brian Popko

  • Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness

    Miki Furusho;Jeffrey L. Dupree;Klaus-Armin Nave;Rashmi Bansal

  • The Neuronal Adhesion Protein TAG-1 Is Expressed by Schwann Cells and Oligodendrocytes and Is Localized to the Juxtaparanodal Region of Myelinated Fibers

    Maria Traka;Jeffrey L. Dupree;Brian Popko;Domna Karagogeos

  • Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination.

    Ye He;Jin Young Kim;Jeffrey Dupree;Ambika Tewari

Frequent Co-Authors

Brian Popko
Brian Popko Northwestern University
Patrizia Casaccia
Patrizia Casaccia City University of New York
Rashmi Bansal
Rashmi Bansal University of Connecticut
Jack Rosenbluth
Jack Rosenbluth New York University
Matthew N. Rasband
Matthew N. Rasband Baylor College of Medicine
Peter J. Brophy
Peter J. Brophy University of Edinburgh
Jacqueline N. Crawley
Jacqueline N. Crawley University of California, Davis
David M. Dietz
David M. Dietz University at Buffalo, State University of New York
Peter Shrager
Peter Shrager University of Rochester Medical Center
Mary Kay Lobo
Mary Kay Lobo University of Maryland, Baltimore

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