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Biology and Biochemistry

D-Index
108
Citations
42667
World Ranking
1046
National Ranking
633

Overview

Xianlin Han is affiliated with The University of Texas Health Science Center at San Antonio in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions also in molecular biology, physiology, surgery, epidemiology, and spectroscopy. Han's work focuses on topics such as metabolomics and mass spectrometry studies, Alzheimer's disease research and treatments, cholesterol and lipid metabolism, adipose tissue and metabolism, peroxisome proliferator-activated receptors, neuroinflammation and neurodegeneration mechanisms, and advanced proteomics techniques and applications.

The researcher has published extensively, with frequent appearances in journals such as bioRxiv (Cold Spring Harbor Laboratory), PROTEOMICS, Nature Communications, Alzheimer s & Dementia, and the Journal of Biological Chemistry.

Among Han's recent papers are the following:

  • Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress, 2020, Cell Metabolism
  • High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance, 2021, Nature Communications
  • The foundations and development of lipidomics, 2021, Journal of Lipid Research
  • Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome, 2020, Nature Communications
  • Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease, 2020, Cell Reports Medicine

Xianlin Han has collaborated frequently with several coauthors, including Rima Kaddurah-Daouk, Matthias Arnold, Meixia Pan, Andrew J. Saykin, and Kwangsik Nho, with collaboration counts ranging from 25 to 39 publications.

Best Publications

  • Triglyceride accumulation protects against fatty acid-induced lipotoxicity

    Laura L. Listenberger;Xianlin Han;Sarah E. Lewis;Sylvaine Cases

  • Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples

    Xianlin Han;Richard W. Gross

  • The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

    Brian N. Finck;John J. Lehman;Teresa C. Leone;Michael J. Welch

  • Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: A bridge to lipidomics

    Xianlin Han;Richard W. Gross

  • Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis.

    Linda J. Pike;Xianlin Han;Koong Nah Chung;Richard W. Gross

  • Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

    Nica M. Borradaile;Xianlin Han;Jeffrey D. Harp;Sarah E. Gale

  • Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.

    Siamak MahmoudianDehkordi;Matthias Arnold;Kwangsik Nho;Shahzad Ahmad

  • A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content

    Brian N. Finck;Xianlin Han;Michael Courtois;Franck Aimond

  • Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

    Xianlin Han;David M. Holtzman;Daniel W. McKeel;John Kelley

  • Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

    Naoki Kumashiro;Derek M. Erion;Dongyan Zhang;Mario Kahn

  • Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses.

    Xianlin Han;Kui Yang;Richard W. Gross

  • Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry.

    Xianlin Han;David M. Holtzman;Daniel W. McKeel

  • Lipidomics for studying metabolism

    Xianlin Han

  • Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences

    Kui Yang;Xianlin Han;Xianlin Han

  • Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy

    Hsiu-Chiang Chiu;Attila Kovacs;Robert M. Blanton;Xianlin Han

  • ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

    Suzanne E. Wahrle;Hong Jiang;Maia Parsadanian;Justin Legleiter

  • Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids

    Xianlin Han;Richard W. Gross

  • Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry.

    Xianlin Han;Richard W. Gross

  • Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.

    Xianlin Han;Steve Rozen;Stephen H. Boyle;Caroline Hellegers

  • Metabolic network failures in Alzheimer's disease: A biochemical road map

    Jon B. Toledo;Jon B. Toledo;Matthias Arnold;Gabi Kastenmüller;Rui Chang

Frequent Co-Authors

Richard W. Gross
Richard W. Gross Washington University in St. Louis
Andrew J. Saykin
Andrew J. Saykin Indiana University
Kwangsik Nho
Kwangsik Nho Indiana University
P. Murali Doraiswamy
P. Murali Doraiswamy Duke University
Gabi Kastenmüller
Gabi Kastenmüller Helmholtz Zentrum München
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Jon B. Toledo
Jon B. Toledo Houston Methodist
Shannon L. Risacher
Shannon L. Risacher Indiana University
Daniel P. Kelly
Daniel P. Kelly University of Pennsylvania
Leslie M. Shaw
Leslie M. Shaw University of Pennsylvania

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