Guojun Bu

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in China Leader Award
• 2025 - Research.com Biology and Biochemistry in China Leader Award
• 2018 - Fellow of the American Association for the Advancement of Science (AAAS)
• 2016 - Metlife Foundation Award for Medical Research in Alzheimer's Disease

Overview

Best Publications

• Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

  Chia Chan Liu;Takahisa Kanekiyo;Huaxi Xu;Guojun Bu

  3948
  Citations

• Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

  Guojun Bu

  1381
  Citations

• Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

  Yu Yamazaki;Na Zhao;Thomas R. Caulfield;Chia Chen Liu

  964
  Citations

• Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

  David M. Holtzman;Joachim Herz;Guojun Bu

  870
  Citations

• TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

  Yingjun Zhao;Xilin Wu;Xiaoguang Li;Lu Lin Jiang

  778
  Citations

• ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?

  Takahisa Kanekiyo;Huaxi Xu;Guojun Bu;Guojun Bu

  741
  Citations

• Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

  John R. Cirrito;Jae Eun Kang;Jiyeon Lee;Floy R. Stewart

  736
  Citations

• ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

  Philip B. Verghese;Joseph M. Castellano;Kanchan Garai;Yinong Wang

  666
  Citations

• Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

  Yuka Atagi;Chia Chen Liu;Meghan M. Painter;Xiao Fen Chen

  644
  Citations

• Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

  Xiaoyan Hu;Scott L. Crick;Guojun Bu;Carl Frieden

  499
  Citations

• Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands.

  Ying Liu;Melina Jones;Cynthia M. Hingtgen;Guojun Bu

  458
  Citations

• Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

  Zhen Zhao;Abhay P Sagare;Qingyi Ma;Matthew R Halliday

  446
  Citations

• Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

  David M. Holtzman;Robert E. Pitas;Joshua Kilbridge;Britto Nathan

  432
  Citations

• Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1

  Qiang Liu;Celina V. Zerbinatti;Juan Zhang;Hyang Sook Hoe

  428
  Citations

• Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator.

  Guojun Bu;Suzanne Williams;Dudley K. Strickland;Alan L. Schwartz

  411
  Citations

• 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein.

  Guojun Bu;H. J. Geuze;G. J. Strous;A. L. Schwartz

  379
  Citations

• α2‐Macroglobulin Complexes with and Mediates the Endocytosis of β‐Amyloid Peptide via Cell Surface Low‐Density Lipoprotein Receptor‐Related Protein

  Masaaki Narita;David M. Holtzman;Alan L. Schwartz;Guojun Bu

  349
  Citations

• Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation.

  Min Zhuo;David M. Holtzman;Yonghe Li;Hiroshi Osaka

  339
  Citations

• Apolipoprotein E-containing High Density Lipoprotein Promotes Neurite Outgrowth and Is a Ligand for the Low Density Lipoprotein Receptor-related Protein

  Anne M. Fagan;Guojun Bu;Yuling Sun;Alan Daugherty

  332
  Citations

• Apolipoprotein E, Receptors, and Modulation of Alzheimer’s Disease

  Na Zhao;Chia Chen Liu;Wenhui Qiao;Guojun Bu;Guojun Bu

  330
  Citations