World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
15025
World Ranking
10712
National Ranking
4650

Overview

Mary Jo LaDu is affiliated with the University of Illinois at Chicago in the United States. Their research is primarily focused on medicine, with significant contributions in biochemistry, genetics, and molecular biology. They have explored various subfields including physiology, endocrinology, diabetes and metabolism, genetics, molecular biology, and surgery.

Their work covers a number of main topics, among which are:

  • Alzheimer's disease research and treatments
  • Estrogen and related hormone effects
  • Menopause: Health Impacts and Treatments
  • Cholesterol and Lipid Metabolism
  • Computational Drug Discovery Methods
  • Cholinesterase and Neurodegenerative Diseases
  • Neuroinflammation and Neurodegeneration Mechanisms

Mary Jo LaDu has published research in several noted scientific venues, including:

  • Alzheimer's & Dementia
  • Nature Aging
  • Alzheimer's Research & Therapy
  • Neurobiology of Aging
  • Frontiers in Aging Neuroscience

Among their recent papers are:

  • "APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β" (2021, Nature Aging)
  • "Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How" (2020, Neurobiology of Disease)
  • "Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models" (2022, Cell Reports)
  • "Murine Gut Microbiome Association With APOE Alleles" (2020, Frontiers in Immunology)
  • "Role of estrogen in women's Alzheimer's disease risk as modified by APOE" (2022, Journal of Neuroendocrinology)

Frequent coauthors working alongside Mary Jo LaDu include:

  • Jason York
  • Ana C. Valencia-Olvera
  • Leon M. Tai
  • Deebika Balu
  • Karyn M. Frick

The research reflects a multidisciplinary approach combining molecular biology and genetics with clinical studies on neurodegenerative diseases. The focus on APOE, estrogen's role in Alzheimer's disease, and mechanisms of neuroinflammation indicates an interest in both fundamental biological processes and their implications in age-related disorders.

Mary Jo LaDu's publications and collaborations contribute to understanding complex interactions affecting Alzheimer's pathology, offering insights that span experimental models to potential therapeutic approaches.

Best Publications

  • Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability

    Karie N. Dahlgren;Arlene M. Manelli;W. Blaine Stine;Lorinda K. Baker

  • In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis

    W. Blaine Stine;Karie N. Dahlgren;Grant A. Krafft;Mary Jo LaDu;Mary Jo LaDu

  • Isoform-specific binding of apolipoprotein E to beta-amyloid.

    Mary J. Ladu;Michael T. Falduto;Arlene M. Manelli;Catherine A. Reardon

  • Preparing Synthetic Aβ in Different Aggregation States

    W. Blaine Stine;Lisa Jungbauer;Chunjiang Yu;Mary Jo LaDu

  • Nascent Astrocyte Particles Differ from Lipoproteins in CSF

    M. J. LaDu;S. M. Gilligan;J. R. Lukens;V. G. Cabana

  • Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides

    Takahiko Tokuda;Miguel Calero;Etsuro Matsubara;Ruben Vidal

  • Differential effects of oligomeric and fibrillar amyloid-β1–42 on astrocyte-mediated inflammation

    Jill A. White;Arlene M. Manelli;Kristina H. Holmberg;Kristina H. Holmberg;Linda J. Van Eldik

  • APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

    Katherine L. Youmans;Leon M. Tai;Evelyn Nwabuisi-Heath;Lisa Jungbauer

  • Glial Fibrillary Acidic Protein–Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins

    Yuling Sun;Shan Wu;Guojun Bu;Moyosore K. Onifade

  • Lipoproteins in the Central Nervous System

    Mary Jo Ladu;Catherine Reardon;Linda Van Eldik;Anne M. Fagan

  • PURIFICATION OF APOLIPOPROTEIN E ATTENUATES ISOFORM-SPECIFIC BINDING TO BETA -AMYLOID

    Mary Jo LaDu;Terry M. Pederson;Donald E. Frail;Catherine A. Reardon

  • ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo

    Sonya B. Dumanis;Joseph A. Tesoriero;Lenard W. Babus;Madeline T. Nguyen

  • Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

    G. Pigino;G. Morfini;Y. Atagi;A. Deshpande

  • Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (−/−), and Human apoE Transgenic Mice *

    Anne M. Fagan;David M. Holtzman;Gregory Munson;Tanya Mathur

  • Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of alzheimer disease

    Terry L. Lewis;Dongfeng Cao;Dongfeng Cao;Hailin Lu;Robert A. Mans

  • APOE genotype alters glial activation and loss of synaptic markers in mice.

    Yuangui Zhu;Evelyn Nwabuisi-Heath;Sonya B. Dumanis;Leon M. Tai

  • Isoform-specific effect of apolipoprotein E on cell survival and β- amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures

    Joaquı́n Jordán;Marı́a F. Galindo;Richard J. Miller;Catherine A. Reardon

  • A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity.

    Ling Guo;Mary Jo LaDu;Mary Jo LaDu;Linda J. Van Eldik

  • Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

    Jie Li;Takahisa Kanekiyo;Mitsuru Shinohara;Yunwu Zhang

  • The generation and function of soluble apoE receptors in the CNS

    G William Rebeck;Mary Jo LaDu;Steven Estus;Guojun Bu

Frequent Co-Authors

Guojun Bu
Guojun Bu Hong Kong University of Science and Technology
Godfrey S. Getz
Godfrey S. Getz University of Chicago
G. William Rebeck
G. William Rebeck Georgetown University Medical Center
Linda J. Van Eldik
Linda J. Van Eldik University of Kentucky
Linda J. Van Eldik
Linda J. Van Eldik University of Kentucky
Edwin J. Weeber
Edwin J. Weeber University of South Florida
Liana G. Apostolova
Liana G. Apostolova Indiana University
Greg M. Cole
Greg M. Cole University of California, Los Angeles
Christian J. Pike
Christian J. Pike University of Southern California

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