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Daniel M. Michaelson

Daniel M. Michaelson

D-Index & Metrics

Neuroscience

D-Index
52
Citations
8340
World Ranking
5385
National Ranking
35

Overview

Daniel M. Michaelson is affiliated with Tel Aviv University in Israel and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work spans multiple subfields including physiology, molecular biology, surgery, oncology, and immunology.

Their research focuses on several key topics:

  • Alzheimer's disease research and treatments
  • Mitochondrial function and pathology
  • Cholesterol and lipid metabolism
  • Drug transport and resistance mechanisms
  • Neutrophil, myeloperoxidase and oxidative mechanisms
  • Nitric oxide and endothelin effects
  • Ubiquitin and proteasome pathways

Recent papers authored by or involving Daniel M. Michaelson include:

  • "Altered mitochondrial dynamics and function in APOE4-expressing astrocytes," 2020, published in Cell Death and Disease
  • "Altered ubiquitin signaling induces Alzheimer's disease-like hallmarks in a three-dimensional human neural cell culture model," 2023, published in Nature Communications
  • "Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology," 2020, published in International Journal of Molecular Sciences
  • "APOE4 impairs autophagy and Aβ clearance by microglial cells," 2025, published in Inflammation Research
  • "9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models," 2023, published in Neurobiology of Aging

Frequent co-authors collaborating with Michaelson include:

  • Shiran Salomon-Zimri
  • Jan O. Johansson
  • Bengt Winblad
  • Henrik Zetterberg
  • Jeffrey L. Cummings

Michaelson's publications have appeared in a variety of venues, with repeated contributions to:

  • Alzheimer's & Dementia
  • Cell Death and Disease
  • Nature Communications
  • International Journal of Molecular Sciences
  • Inflammation Research

Their work addresses complex mechanisms underlying neurodegenerative diseases such as Alzheimer's disease, with particular attention to molecular pathways involving mitochondrial function, lipid metabolism, and protein degradation systems. The involvement in both central and peripheral mechanisms in disease pathology is reflected in their multidisciplinary research outputs.

Best Publications

  • ApoE4: an emerging therapeutic target for Alzheimer's disease.

    Mirna Safieh;Amos D. Korczyn;Daniel M. Michaelson

  • APOE ε4: the most prevalent yet understudied risk factor for Alzheimer's disease.

    Daniel M. Michaelson

  • Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice.

    Irit Gordon;Ettie Grauer;Idit Genis;Ephraim Sehayek

  • Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury.

    Y Chen;L Lomnitski;D.M Michaelson;E Shohami

  • APOE genotype is a major predictor of long-term progression of disability in MS

    J. Chapman;S. Vinokurov;A. Achiron;D. M. Karussis

  • Apolipoprotein E4 enhances brain inflammation by modulation of the NF-κB signaling cascade

    Gal Ophir;Ninette Amariglio;Jasmine Jacob-Hirsch;Ran Elkon

  • ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.

    Ofir Levi;Ana L Jongen-Relo;Joram Feldon;Allen D Roses

  • Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene

    Anat Boehm-Cagan;Daniel M Michaelson

  • ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes.

    Varun Rawat;Shaowei Wang;Jian Sima;Roni Bar

  • Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C

    Anthony H. Futerman;Martin G. Low;Daniel M. Michaelson;Israel Silman

  • Impaired Autophagy in APOE4 Astrocytes

    Shira Simonovitch;Eran Schmukler;Alina Bespalko;Tal Iram

  • ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

    Ori Liraz;Anat Boehm-Cagan;Daniel M Michaelson

  • Activation of the Amyloid Cascade in Apolipoprotein E4 Transgenic Mice Induces Lysosomal Activation and Neurodegeneration Resulting in Marked Cognitive Deficits

    Haim Belinson;Dimitri Lev;Eliezer Masliah;Daniel M. Michaelson

  • Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: The allele E3 is neuroprotective whereas E4 increases fatalities

    T Sabo;L Lomnitski;A Nyska;S Beni

  • ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies.

    Anat Boehm-Cagan;Roni Bar;Ori Liraz;John K Bielicki

  • Antibodies to brain antigens following stroke.

    N.M. Bornstein;B. Aronovich;A.D. Korczyn;S. Shavit

  • Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer’s disease: a rationale for multi-nutrient dementia prevention

    Marcus O.W. Grimm;Daniel M. Michaelson;Tobias Hartmann

  • Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic mice.

    Ofir Levi;Daniel M. Michaelson

  • Induced acetylcholine release from active purely cholinergic Torpedo synaptosomes.

    D. M. Michaelson;M. Sokolovsky

  • Mechanism of acetylcholine release: possible involvement of presynaptic muscarinic receptors in regulation of acetylcholine release and protein phosphorylation.

    Daniel M. Michaelson;Sofia Avissar;Yoel Kloog;Mordechai Sokolovsky

Frequent Co-Authors

Joab Chapman
Joab Chapman Tel Aviv University
Joram Feldon
Joram Feldon ETH Zurich
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Helena C. Chui
Helena C. Chui University of Southern California
Michael G. Harrington
Michael G. Harrington University of Southern California
Abraham Fisher
Abraham Fisher Israel Institute for Biological Research
Henrik Zetterberg
Henrik Zetterberg University of Gothenburg
Heikki Tanila
Heikki Tanila University of Eastern Finland
Chaim G. Pick
Chaim G. Pick Tel Aviv University
Kobi Rosenblum
Kobi Rosenblum University of Haifa

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