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Neuroscience

D-Index
47
Citations
7087
World Ranking
6509
National Ranking
47

Overview

Abraham Fisher is affiliated with the Israel Institute for Biological Research in Israel. Their research contributions span several interconnected fields with a primary focus on the biochemical and molecular biology aspects of neurological conditions.

Their scientific publications cover key areas within biochemistry, genetics, and molecular biology, alongside medicine. The three main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, Fisher has explored subfields that further specify the nature of scientific inquiry, including:

  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience

The scientific topics addressed in their work reflect a focus on neurodegenerative disease mechanisms and receptor function, such as:

  • Cholinesterase and Neurodegenerative Diseases
  • Nicotinic Acetylcholine Receptors Study
  • Phosphodiesterase function and regulation
  • Receptor Mechanisms and Signaling
  • Neuroscience and Neuropharmacology Research

Fisher has coauthored research with several notable collaborators. Frequent coauthors include:

  • Ezio Giacobini
  • A. Claudio Cuello
  • Allan I. Levey

Fisher's publications appear in specialized venues relevant to neurology and brain research, including:

  • Brain
  • Handbook of clinical neurology

Among recent academic outputs, two papers stand out:

  • Reimagining cholinergic therapy for Alzheimer's disease (2022, Brain)
  • CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment (2025, Handbook of clinical neurology)

Their ongoing work evidently centers around cholinergic mechanisms in neurodegenerative diseases, with a specific emphasis on Alzheimer's disease therapies and receptor-targeted pharmacology.

Best Publications

  • M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice

    Antonella Caccamo;Salvatore Oddo;Lauren M. Billings;Kim N. Green

  • Long-term central cholinergic hypofunction induced in mice by ethylcholine aziridinium ion (AF64A) in vivo.

    A Fisher;C R Mantione;D J Abraham;I Hanin

  • Activation of m1 Muscarinic Acetylcholine Receptor Regulates τ Phosphorylation in Transfected PC12 Cells

    Einat Sadot;David Gurwitz;Jacob Barg;Leah Behar

  • AF64A, a cholinergic neurotoxin, selectively depletes acetylcholine in hippocampus and cortex, and produces long-term passive avoidance and radial-arm maze deficits in the rat.

    Thomas J. Walsh;Hugh A. Tilson;Diane L. DeHaven;Richard B. Mailman

  • M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.

    Abraham Fisher;Zipora Pittel;Rachel Haring;Nira Bar-Ner

  • Cholinergic Treatments with Emphasis on M1 Muscarinic Agonists as Potential Disease-Modifying Agents for Alzheimer's Disease

    Abraham Fisher

  • Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer's disease.

    Abraham Fisher

  • Selective presynaptic cholinergic neurotoxicity following intrahippocampal AF64A injection in rats.

    Charles R. Mantione;Michael J. Zigmond;Abraham Fisher;Israel Hanin

  • Mitogen-Activated Protein Kinase-Dependent and Protein Kinase C-Dependent Pathways Link the m1 Muscarinic Receptor to β-Amyloid Precursor Protein Secretion

    Rachel Haring;Abraham Fisher;Daniele Marciano;Zipora Pittel

  • Discrete activation of transduction pathways associated with acetylcholine m1 receptor by several muscarinic ligands

    David Gurwitz;Rachel Haring;Eliahu Heldman;Claire M. Fraser

  • Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists.

    Abraham Fisher

  • Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease?

    N. Bons;F. Rieger;D. Prudhomme;A. Fisher

  • Potential animal models for senile dementia of Alzheimer's type, with emphasis on AF64A-induced cholinotoxicity.

    Unknown

  • Loss of Muscarinic M1 Receptor Exacerbates Alzheimer's Disease–Like Pathology and Cognitive Decline

    Rodrigo Medeiros;Masashi Kitazawa;Antonella Caccamo;David Baglietto-Vargas

  • Use of muscarinic agonists in the treatment of Sjögren's syndrome.

    Robert I. Fox;Yrjö Konttinen;Abraham Fisher

  • Selective cholinergic neurotoxin: AF64A's effects in rat striatum.

    K. Sandberg;I. Hanin;A. Fisher;J.T. Coyle

  • The AF64a-treated mouse: possible model for central cholinergic hypofunction.

    Unknown

  • Choline analogs as potential tools in developing selective animal models of central cholinergic hypofunction.

    Unknown

  • Progress In Alzheimer's And Parkinson's Diseases

    Abraham Fisher;Israel Hanin;充男 吉田;Makhon le-mehkar biyologi be-Yisraʾel

  • AF64A: An Active Site Directed Irreversible Inhibitor of Choline Acetyltransferase

    K. Sandberg;R. L. Schnaar;M. McKinney;I. Hanin

  • (+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.

    A Fisher;R Brandeis;I Karton;Z Pittel

  • Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102B

    R. Brandeis;S. Dachir;M. Sapir;A. Levy

  • (+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3') quinuclidine (AF102B): a new M1 agonist attenuates cognitive dysfunctions in AF64A-treated rats.

    A. Fisher;R. Brandeis;Z. Pittel;I. Karton

  • M1 Agonists for the Treatment of Alzheimer's Disease.

    A. Fisher;E. Heldman;D. Gurwitz;R. Haring

Frequent Co-Authors

Eric Halgren
Eric Halgren University of California, San Diego
Daniel M. Michaelson
Daniel M. Michaelson Tel Aviv University
Antonella Caccamo
Antonella Caccamo University of Messina
Menahem Segal
Menahem Segal Weizmann Institute of Science
Salvatore Oddo
Salvatore Oddo Arizona State University
Joseph O'Neill
Joseph O'Neill University of California, Los Angeles
Douglas G. Walker
Douglas G. Walker Arizona State University
Kim N. Green
Kim N. Green University of California, Irvine
Nibaldo C. Inestrosa
Nibaldo C. Inestrosa Pontificia Universidad Católica de Chile
Ilya Bezprozvanny
Ilya Bezprozvanny The University of Texas Southwestern Medical Center

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