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Neuroscience

D-Index
38
Citations
4913
World Ranking
8617
National Ranking
10

Overview

Mitchell K.P. Lai is affiliated with the National University of Singapore in Singapore. Their research primarily focuses on medicine and neuroscience, with significant contributions in neurology, molecular biology, physiology, psychiatry and mental health, and cardiology and cardiovascular medicine. The scientist's work covers various interconnected topics within neurological disease mechanisms, Alzheimer's disease, neuroinflammation, dementia, neurological disorders, inflammasomes, and Parkinson's disease.

Lai has published extensively on neurological conditions, particularly vascular cognitive impairment and Alzheimer's disease biomarkers. Some recent publications include:

  • Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment (2022, Theranostics)
  • AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia (2020, Molecular Psychiatry)
  • The role of inflammasomes in vascular cognitive impairment (2022, Molecular Neurodegeneration)
  • Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment (2023, Acta Neuropathologica Communications)
  • Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent advances (2021, Journal of Neurology Neurosurgery & Psychiatry)

Frequent coauthors collaborating with Mitchell K.P. Lai include Christopher Chen, Joyce R. Chong, Saima Hilal, Thiruma V. Arumugam, and Narayanaswamy Venketasubramanian. These collaborations have contributed to a diverse range of studies largely centered on neurological diseases and cognitive impairments.

The scientist's publications often appear in journals specializing in aging, dementia, and neurological research. The top venues for their work include:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer s Research & Therapy
  • Journal of Alzheimer s Disease
  • Theranostics

Mitchell K.P. Lai's main research fields emphasize medicine with a focus on neurological conditions and neuroscience. The subfields of their work highlight neurology, molecular biology, physiology, psychiatry, mental health, and cardiovascular medicine, reflecting an interdisciplinary approach to studying the mechanisms and treatments of neurological diseases.

The topics most frequently addressed in their research are:

  • Neurological Disease Mechanisms and Treatments
  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Dementia and Cognitive Impairment Research
  • Neurological Disorders and Treatments
  • Inflammasome and immune disorders
  • Parkinson's Disease Mechanisms and Treatments

Best Publications

  • Ageing and the telomere connection: An intimate relationship with inflammation.

    Jingwen Zhang;Grishma Rane;Xiaoyun Dai;Muthu K. Shanmugam

  • Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias

    David R. Howlett;David Whitfield;Mary Johnson;Johannes Attems

  • Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease.

    Mitchell K.P. Lai;Shirley W.Y. Tsang;Paul T. Francis;Margaret M. Esiri

  • The role of inflammasomes in vascular cognitive impairment

    Unknown

  • AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia.

    Luting Poh;David Y. Fann;Peiyan Wong;Hong Meng Lim

  • Psychosis of Alzheimer's disease is associated with elevated muscarinic M2 binding in the cortex

    M K P Lai;O F Lai;J Keene;M M Esiri

  • Extracellular vesicles are rapidly purified from human plasma by PRotein Organic Solvent PRecipitation (PROSPR)

    Xavier Gallart-Palau;Aida Serra;Andrew See Weng Wong;Sara Sandin

  • Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease.

    Michelle G. Tan;Wei-Ting Chua;Wei-Ting Chua;Margaret M. Esiri;A. David Smith

  • Neurochemical basis for symptomatic treatment of Alzheimer's disease.

    Paul T. Francis;María J. Ramírez;Mitchell K. Lai;Mitchell K. Lai

  • Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease.

    M K Lai;M K Lai;S W Tsang;J T Alder;J Keene

  • Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease.

    Shirley W.Y. Tsang;Mitchell K.P. Lai;Mitchell K.P. Lai;Sara Kirvell;Paul T. Francis

  • Postmortem serotoninergic correlates of cognitive decline in Alzheimer's disease.

    Mitchell K. P. Lai;Shirley W. Y. Tsang;Paul T. Francis;Janet Keene

  • Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent advances.

    Joyce R. Chong;Nicholas J. Ashton;Thomas K. Karikari;Tomotaka Tanaka

  • Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease

    Monica Garcia-Alloza;Shirley W. Tsang;Francisco J. Gil-Bea;Paul T. Francis

  • The brain lipidomes of subcortical ischemic vascular dementia and mixed dementia

    Sin Man Lam;Sin Man Lam;Yuting Wang;Xinrui Duan;Markus R. Wenk

  • Serotonergic Therapies for Cognitive Symptoms in Alzheimer’s Disease: Rationale and Current Status

    Maria J. Ramirez;Mitchell K. P. Lai;Mitchell K. P. Lai;Rosa M. Tordera;Paul T. Francis

  • Markers of cardiac dysfunction in cognitive impairment and dementia.

    Saima Hilal;Yuek Ling Chai;Mohammad Kamran Ikram;Sakktivel Elangovan

  • Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular disease.

    Joyce R Chong;Joyce R Chong;Nicholas J Ashton;Thomas K Karikari;Tomotaka Tanaka;Tomotaka Tanaka

  • F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy

    Zhi Dong Zhou;Shao Ping Xie;Sushmitha Sathiyamoorthy;Wuan Ting Saw

  • Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex

    Jasinda H. Lee;Grzegorz Agacinski;Jonathan H. Williams;Gordon K. Wilcock

  • Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice.

    A. D. Medhurst;J. C. Roberts;J. Lee;C. P. L.-H. Chen

  • Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK.

    Siew Ying Wong;Michelle G. K. Tan;Michelle G. K. Tan;Peter T. H. Wong;Deron R. Herr

Frequent Co-Authors

Paul T. Francis
Paul T. Francis University of Exeter
Margaret M. Esiri
Margaret M. Esiri University of Oxford
Dag Aarsland
Dag Aarsland King's College London
Raj N. Kalaria
Raj N. Kalaria Newcastle University
Gavin S. Dawe
Gavin S. Dawe National University of Singapore
Kaj Blennow
Kaj Blennow University of Gothenburg
Andrew L. Gundlach
Andrew L. Gundlach Florey Institute of Neuroscience and Mental Health
Jeffrey L. Cummings
Jeffrey L. Cummings University of Nevada, Las Vegas
Wei-Yi Ong
Wei-Yi Ong National University of Singapore
Eng-King Tan
Eng-King Tan National University of Singapore

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