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Neuroscience

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Medicine

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Overview

Paul T. Francis is affiliated with the University of Exeter in the United Kingdom. Their research spans fields including Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields such as Molecular Biology, Psychiatry and Mental Health, Physiology, Neurology, and Genetics.

The scientist's work primarily focuses on topics such as Dementia and Cognitive Impairment Research, Alzheimer's Disease Research and Treatments, Epigenetics and DNA Methylation, Parkinson's Disease Mechanisms and Treatments, Intergenerational Family Dynamics and Caregiving, Genetic Syndromes and Imprinting, and Bioinformatics and Genomic Networks.

Frequent coauthors collaborating with Paul T. Francis include Alan Thomas, Seth Love, Kevin Morgan, Jonathan Mill, and Clive Ballard.

Key publication venues where their research has appeared include:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Brain
  • Molecular Psychiatry

Representative recent papers authored or coauthored by Paul T. Francis are:

  • "Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex," 2020, Brain
  • "A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex," 2021, Nature Communications
  • "Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management," 2020, Journal of Neurology Neurosurgery & Psychiatry
  • "Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain," 2020, Molecular Psychiatry
  • "DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types," 2022, Nature Communications

Best Publications

  • The cholinergic hypothesis of Alzheimer’s disease: a review of progress

    Paul T Francis;Alan M Palmer;Michael Snape;Gordon K Wilcock

  • Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

    Madhav Thambisetty;Andrew Simmons;Latha Velayudhan;Abdul Hye

  • Correction: Corrigendum: Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer’s Disease

    Omar Kassaar;Marta Pereira Morais;Suying Xu;Emily L. Adam

  • Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy.

    David G. Wilkinson;Paul T. Francis;Elias Schwam;Jennifer Payne-Parrish

  • Neurochemical studies of early-onset Alzheimer's disease. Possible influence on treatment.

    Paul T. Francis;Alan M. Palmer;Neil R. Sims;David M. Bowen

  • Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future

    Yonas E. Geda;Lon S. Schneider;Laura N. Gitlin;David S. Miller

  • The Interplay of Neurotransmitters in Alzheimer's Disease

    Paul T Francis

  • Glutamatergic systems in Alzheimer's disease

    Paul T. Francis

  • Cortical Pyramidal Neurone Loss May Cause Glutamatergic Hypoactivity and Cognitive Impairment in Alzheimer's Disease: Investigative and Therapeutic Perspectives

    Paul T. Francis;Neil R. Sims;Andrew W. Procter;David M. Bowen

  • Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease

    M. Garcia-Alloza;F.J. Gil-Bea;M. Diez-Ariza;C.P.L.-H. Chen

  • Presynaptic serotonergic dysfunction in patients with Alzheimer's disease.

    A. M. Palmer;P. T. Francis;J. S. Benton;N. R. Sims

  • Noradrenergic changes, aggressive behavior, and cognition in patients with dementia

    Kim L Matthews;Christopher P.L.-H Chen;Margaret M Esiri;Janet Keene

  • Metals ions and neurodegeneration

    Francisco Molina-Holgado;Robert C. Hider;Alessandra Gaeta;Robert Williams

  • Evidence of Glutamatergic Denervation and Possible Abnormal Metabolism in Alzheimer's Disease

    A. W. Procter;A. M. Palmer;P. T. Francis;S. L. Lowe

  • AddNeuroMed—The European Collaboration for the Discovery of Novel Biomarkers for Alzheimer's Disease

    Simon Lovestone;Paul Francis;Iwona Kloszewska;Patrizia Mecocci

  • Cholinergic deficits contribute to behavioral disturbance in patients with dementia

    Stephen Minger;M M Esiri;B McDonald;J Keene

  • Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease

    Alan M. Palmer;Gordon K. Wilcock;Margaret M. Esiri;Paul T. Francis

  • Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias

    David R. Howlett;David Whitfield;Mary Johnson;Johannes Attems

  • Apathy associated with neurocognitive disorders: Recent progress and future directions

    Krista L. Lanctôt;Krista L. Lanctôt;Luis Agüera-Ortiz;Henry Brodaty;Paul T. Francis

  • Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach.

    Erika Bereczki;Rui M. Branca;Paul T. Francis;Joana B. Pereira

  • Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease.

    Sara L. Kirvell;Margaret Esiri;Paul T. Francis

Frequent Co-Authors

David M. Bowen
David M. Bowen University of Oxford
Mitchell K.P. Lai
Mitchell K.P. Lai National University of Singapore
Clive Ballard
Clive Ballard University of Exeter
Dag Aarsland
Dag Aarsland King's College London
Christopher Chen
Christopher Chen National University of Singapore
Margaret M. Esiri
Margaret M. Esiri University of Oxford
Tibor Hortobágyi
Tibor Hortobágyi University of Debrecen
Johannes Attems
Johannes Attems Newcastle University
Alan J. Thomas
Alan J. Thomas Newcastle University
Alan M. Palmer
Alan M. Palmer Elixa MediScience

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