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130
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Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Simon Lovestone is affiliated with the University of Oxford in the United Kingdom. Their main research fields include Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Physiology, Molecular Biology, Psychiatry and Mental Health, Neurology, and Genetics.

The core topics of Lovestone's work are centered on Alzheimer's disease research and treatments, dementia and cognitive impairment research, bioinformatics and genomic networks, genetic associations and epidemiology, neuroinflammation and neurodegeneration mechanisms, epigenetics and DNA methylation, and the relationship between tryptophan and brain disorders.

Lovestone has coauthored numerous papers with frequent collaborators including Henrik Zetterberg, Pieter Jelle Visser, Julius Popp, Johannes Streffer, and Magda Tsolaki. This collaborative network reflects an ongoing engagement with experts in neurodegenerative research and related areas.

Notable recent publications by Lovestone include:

  • The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease, 2021, Alzheimer s & Dementia
  • Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics, 2020, Brain
  • The reliability of a deep learning model in clinical out-of-distribution MRI data: A multicohort study, 2020, Medical Image Analysis
  • Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease, 2021, Alzheimer s Research & Therapy
  • Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders, 2021, Genome biology

Lovestone's research is frequently published in specialized venues such as Alzheimer s & Dementia, bioRxiv (Cold Spring Harbor Laboratory), Alzheimer s Research & Therapy, Brain, and Molecular Neurodegeneration, reflecting a strong focus on neurodegenerative diseases and their biochemical underpinnings.

In recognition of their contributions to medical science, Simon Lovestone has been awarded the title of Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB) Report of the consortium on DLB international workshop

    I. G. Mckeith;D. Galasko;K. Kosaka;E. K. Perry

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))

    D Harold;R Abraham;P Hollingworth;R Sims

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

    Antonio F. Pardiñas;Peter Holmans;Andrew J. Pocklington;Valentina Escott-Price

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • The GSK3 hypothesis of Alzheimer's disease.

    Claudie Hooper;Richard Killick;Simon Lovestone

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Common genetic variants influence human subcortical brain structures.

    Derrek P. Hibar;Jason L. Stein;Jason L. Stein;Miguel E. Renteria;Alejandro Arias-Vasquez

  • Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

    Lesley Jones;Peter A. Holmans;Marian L. Hamshere;Denise Harold

  • Head injury as a risk factor for Alzheimer’s disease: the evidence 10 years on; a partial replication

    S Fleminger;D L Oliver;S Lovestone;S Rabe-Hesketh

  • Alzheimer's disease – do tauists and baptists finally shake hands?

    Amritpal Mudher;Simon Lovestone

  • Is MCI really just early dementia? A systematic review of conversion studies

    Maddalena Bruscoli;Simon Lovestone

  • Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

    Matthew N Davies;Manuela Volta;Ruth Pidsley;Katie Lunnon

  • Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

    S Lovestone;C H Reynolds;D Latimer;Davis

  • Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop

    Ian G. McKeith

  • Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease

    Hao Li;Sally Wetten;Li Li;Pamela L. St. Jean

  • Proteome-based plasma biomarkers for Alzheimer's disease

    A Hye;Steven Lynham;Madhav Thambisetty;M Causevic

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimertextquotesingles disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

Frequent Co-Authors

Andrew Simmons
Andrew Simmons King's College London
Magda Tsolaki
Magda Tsolaki Aristotle University of Thessaloniki
Patrizia Mecocci
Patrizia Mecocci University of Perugia
Hilkka Soininen
Hilkka Soininen University of Eastern Finland
Julie Williams
Julie Williams Cardiff University
Eric Westman
Eric Westman Karolinska Institute
Bruno Vellas
Bruno Vellas Federal University of Toulouse Midi-Pyrénées
Michael John Owen
Michael John Owen Cardiff University
Pieter Jelle Visser
Pieter Jelle Visser Amsterdam University Medical Centers
John Powell
John Powell King's College London

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