World's Best Scientists 2026 revealed!
A. Claudio Cuello

A. Claudio Cuello

D-Index & Metrics

Neuroscience

D-Index
69
Citations
15790
World Ranking
2652
National Ranking
152

Research.com Recognitions

  • 1997 - Fellow of the Royal Society of Canada Academy of Science

Overview

A. Claudio Cuello is affiliated with McGill University in Canada and has contributed extensively to the fields of Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. Their research encompasses several specialized subfields, including Physiology, Molecular Biology, Neurology, Cellular and Molecular Neuroscience, and Cognitive Neuroscience.

The primary topics addressed in Cuello's work include:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Dementia and Cognitive Impairment Research
  • Neuroscience and Neuropharmacology Research
  • Memory and Neural Mechanisms
  • Cholinesterase and Neurodegenerative Diseases
  • Down syndrome and intellectual disability research

Cuello has published research in a variety of scientific journals, with frequent contributions to:

  • Alzheimer s & Dementia
  • Neurobiology of Disease
  • Handbook of Clinical Neurology
  • Neurobiology of Aging
  • Nature Communications

Among recent publications, notable papers include:

  • "A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease" (2020), published in Frontiers in Immunology
  • "Reimagining cholinergic therapy for Alzheimer's disease" (2022), published in Brain
  • "eIF2α controls memory consolidation via excitatory and somatostatin neurons" (2020), published in Nature
  • "Connecting the "Dots": From Free Radical Lipid Autoxidation to Cell Pathology and Disease" (2020), published in Chemical Reviews
  • "Evolution of neuroinflammation across the lifespan of individuals with Down syndrome" (2020), published in Brain

Frequent collaborators in Cuello's research include:

  • Sonia Do Carmo, with 33 joint publications
  • Pedro Rosa-Neto, with 14 joint publications
  • Sylvia Villeneuve, with 12 joint publications
  • M. Mallar Chakravarty, with 11 joint publications
  • Harald Hampel, with 10 joint publications

In recognition of contributions to science, Cuello was awarded the title of Fellow of the Royal Society of Canada in 1997 within the Academy of Science.

Best Publications

  • The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.

    Harald Hampel;M.-Marsel Mesulam;A Claudio Cuello;Martin R Farlow

  • The distribution of substance P immunoreactive fibers in the rat central nervous system

    A. Claudio Cuello;Ichiro Kanazawa

  • Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase, GCN2

    Mauro Costa-Mattioli;Delphine Gobert;Heather Harding;Barbara Herdy

  • Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade

    Martin A. Bruno;A. Claudio Cuello

  • The central and peripheral ends of the substance P-containing sensory neurones in the rat trigeminal system.

    A. Claudio Cuello;Marina Del Fiacco;George Paxinos

  • Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research

    Harald Hampel;M.-M. Mesulam;A. C. Cuello;A. S. Khachaturian

  • A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease.

    Harald Hampel;Filippo Caraci;A Claudio Cuello;Giuseppe Caruso

  • The anatomy of the CNS cholinergic neurons

    A. Claudio Cuello;Michael V. Sofroniew

  • Substance P and Neurokinins

    James L. Henry;Rejean Couture;A. Claudio Cuello;Georges Pelletier

  • Modeling Alzheimer’s disease in transgenic rats

    Sonia Do Carmo;A Claudio Cuello

  • Reorganization of Cholinergic Terminals in the Cerebral Cortex and Hippocampus in Transgenic Mice Carrying Mutated Presenilin-1 and Amyloid Precursor Protein Transgenes

    Tak Pan Wong;Thomas Debeir;Karen Duff;A. Claudio Cuello

  • A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment

    Wanda Carolina Leon;Fabio Canneva;Vanessa Partridge;Simon Allard

  • Increased Matrix Metalloproteinase-9 Activity in Mild Cognitive Impairment

    Martin A. Bruno;Elliott J. Mufson;Joanne Wuu;A. Claudio Cuello

  • Altered synaptic function in Alzheimer's disease.

    Karen F.S. Bell;A. Claudio Cuello

  • Amyloid β-Induced Nerve Growth Factor Dysmetabolism in Alzheimer Disease

    Martin A. Bruno;Wanda C. Leon;Gabriela Fragoso;Walter E. Mushynski

  • Paradoxical Upregulation of Glutamatergic Presynaptic Boutons during Mild Cognitive Impairment

    Karen F S Bell;David A Bennett;A Claudio Cuello

  • Early and Late CNS Inflammation in Alzheimer’s Disease: Two Extremes of a Continuum?

    A. Claudio Cuello

  • Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

    Maria Teresa Ferretti;Martin A. Bruno;Adriana Ducatenzeiler;William L. Klein

  • Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease

    Cecilia E. Hanzel;Alexa Pichet-Binette;Luisa S.B. Pimentel;M. Florencia Iulita

  • The amyloid pathology progresses in a neurotransmitter-specific manner

    Karen F.S. Bell;Adriana Ducatenzeiler;Alfredo Ribeiro-da-Silva;Karen Duff

  • ADAM-10 over-expression increases cortical synaptogenesis.

    Karen F.S. Bell;Luyu Zheng;Falk Fahrenholz;A. Claudio Cuello

  • Gangliosides potentiate in vivo and in vitro effects of nerve growth factor on central cholinergic neurons.

    Unknown

Frequent Co-Authors

Alfredo Ribeiro-da-Silva
Alfredo Ribeiro-da-Silva McGill University
Pedro Rosa-Neto
Pedro Rosa-Neto McGill University
Jean-Paul Soucy
Jean-Paul Soucy Montreal Neurological Institute and Hospital
Eduardo R. Zimmer
Eduardo R. Zimmer Federal University of Rio Grande do Sul
David A. Bennett
David A. Bennett Rush University Medical Center
Michael J. Rowan
Michael J. Rowan Trinity College Dublin
Peter J. Snyder
Peter J. Snyder University of Rhode Island
William L. Klein
William L. Klein Northwestern University
George Paxinos
George Paxinos Neuroscience Research Australia
Karen Duff
Karen Duff University College London

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