World's Best Scientists 2026 revealed!
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Biology and Biochemistry
UK
2026

D-Index & Metrics

Neuroscience

D-Index
100
Citations
51281
World Ranking
747
National Ranking
90

Biology and Biochemistry

D-Index
100
Citations
51241
World Ranking
1486
National Ranking
90

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Karen Duff is affiliated with University College London in the United Kingdom. Their research primarily focuses on various aspects of neuroscience and neurodegenerative diseases, with a particular emphasis on Alzheimer's disease.

Their recent publications cover topics related to tau pathology, neuroinflammation, and neurodegeneration. Notable papers include:

  • In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease, 2021, Science Advances
  • Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease, 2022, Acta Neuropathologica Communications
  • Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease, 2023, JAMA Neurology
  • Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus, 2020, PLoS Biology
  • Chronic effects of inflammation on tauopathies, 2023, The Lancet Neurology

The main fields of study for this scientist include Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. Their work often intersects several subfields such as Physiology, Molecular Biology, Cellular and Molecular Neuroscience, Neurology, and Psychiatry and Mental health.

Karen Duff's research topics cover a range of areas connected to neurodegenerative conditions, including:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Cholinesterase and Neurodegenerative Diseases
  • Dementia and Cognitive Impairment Research
  • Prion Diseases and Protein Misfolding
  • Extracellular vesicles in disease

The scientist has published extensively in several venues, with frequent contributions to:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • Acta Neuropathologica Communications
  • Nature Neuroscience

They have collaborated repeatedly with a group of coauthors, including Emir Turkes, Stephanie L. Fowler, Sumi Bez, Helen Y. Figueroa, and Martha Foiani.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

    Dave Morgan;David M. Diamond;Paul E. Gottschall;Kenneth E. Ugen

  • Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

    Karen Duff;Karen Duff;Chris Eckman;Cindy Zehr;Cindy Zehr;Xin Yu

  • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

    Leigh Holcomb;Marcia N. Gordon;Eileen Mcgowan;Xin Yu

  • Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.

    Jada Lewis;Eileen McGowan;Julia Rockwood;Heather Melrose

  • Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.

    Lorenzo M. Refolo;Miguel A. Pappolla;Brian Malester;John LaFrancois

  • Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

    W Haung Yu;Ana Maria Cuervo;Asok Kumar;Corrinne M. Peterhoff

  • Trans-Synaptic Spread of Tau Pathology In Vivo

    Li Liu;Valerie Drouet;Jessica W. Wu;Menno P. Witter

  • Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

    Wendy Noble;Emmanuel Planel;Cindy Zehr;Vicki Olm

  • Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration

    Carlos A. Saura;Se Young Choi;Vassilios Beglopoulos;Seema Malkani

  • Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

    Cathy Andorfer;Yvonne Kress;Marisol Espinoza;Rohan De Silva

  • Neuronal activity enhances tau propagation and tau pathology in vivo

    Jessica W Wu;S Abid Hussaini;Isle M Bastille;Gustavo A Rodriguez

  • Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis

    Scott A. Small;Karen Duff

  • A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

    L. M. Refolo;Miguel Pappolla;J. LaFrancois;B. Malester

  • Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

    Julia Tsai;Jaime Grutzendler;Jaime Grutzendler;Karen Duff;Wen-Biao Gan

  • Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.

    Robin B. Chan;Tiago Gil Oliveira;Etty P. Cortes;Lawrence S. Honig

  • Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

    Usman A Khan;Li Liu;Frank A Provenzano;Diego E Berman

  • Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms

    Cathy A. Andorfer;Christopher M. Acker;Yvonne Kress;Patrick R Hof

  • Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

    Jessica W. Wu;Mathieu Herman;Li Liu;Sabrina Simoes

  • Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

    Wendy Noble;Vicki Olm;Kazuyuki Takata;Evelyn Casey

Frequent Co-Authors

Ralph A. Nixon
Ralph A. Nixon Nathan Kline Institute for Psychiatric Research
John Hardy
John Hardy University College London
Mike Hutton
Mike Hutton Eli Lilly (United States)
Scott A. Small
Scott A. Small Columbia University
Emmanuel Planel
Emmanuel Planel Université Laval
Peter Davies
Peter Davies University of Queensland
Elisa E. Konofagou
Elisa E. Konofagou Columbia University
Paul M. Mathews
Paul M. Mathews New York University
Rong Wang
Rong Wang Icahn School of Medicine at Mount Sinai

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