Paul M. Mathews

Overview

Best Publications

• Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

  Christopher Janus;Jacqueline Pearson;JoAnne McLaurin;Paul M. Mathews

  2019
  Citations

• Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

  W Haung Yu;Ana Maria Cuervo;Asok Kumar;Corrinne M. Peterhoff

  1195
  Citations

• Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

  Rebecca Radde;Tristan Bolmont;Stephan A Kaeser;Janaky Coomaraswamy

  1149
  Citations

• Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.

  Melanie Meyer-Luehmann;Janaky Coomaraswamy;Tristan Bolmont;Tristan Bolmont;Stephan Kaeser

  1124
  Citations

• Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy

  M. Pfeifer;S. Boncristiano;L. Bondolfi;A. Stalder

  807
  Citations

• Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia

  Stefan Grathwohl;R.E. Kälin;T. Bolmont;S. Prokop

  599
  Citations

• Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice

  Fabrizio Trinchese;Shumin Liu;Shumin Liu;Fortunato Battaglia;Fortunato Battaglia;Sean Walter;Sean Walter

  526
  Citations

• Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

  Dun Sheng Yang;Dun Sheng Yang;Philip Stavrides;Panaiyur S. Mohan;Panaiyur S. Mohan;Susmita Kaushik

  504
  Citations

• Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

  Martin C Herzig;David T Winkler;Patrick Burgermeister;Michelle Pfeifer;Michelle Pfeifer

  504
  Citations

• The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review.

  Ralph A. Nixon;Ralph A. Nixon;Anne M. Cataldo;Anne M. Cataldo;Paul M. Mathews

  445
  Citations

• Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology

  Ina Tesseur;Kun Zou;Luke Esposito;Frederique Bard

  368
  Citations

• Alzheimer’s-related endosome dysfunction in Down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition

  Ying Jiang;Kerry A. Mullaney;Corrinne M. Peterhoff;Shaoli Che

  334
  Citations

• Rab5-stimulated Up-regulation of the Endocytic Pathway Increases Intracellular β-Cleaved Amyloid Precursor Protein Carboxyl-terminal Fragment Levels and Aβ Production *

  Olivera M. Grbovic;Paul M. Mathews;Paul M. Mathews;Ying Jiang;Stephen D. Schmidt

  286
  Citations

• Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.

  Fabrizio Trinchese;Mauro Fa;Shumin Liu;Hong Zhang

  279
  Citations

• In vivo reduction of amyloid-β by a mutant copper transporter

  Amie L. Phinney;Bettina Drisaldi;Stephen D. Schmidt;Stan Lugowski

  271
  Citations

• Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models.

  Weiqian Mi;Monika Pawlik;Magdalena Sastre;Magdalena Sastre;Sonia S Jung

  246
  Citations

• Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation.

  P. Beguin;A.T. Beggah;A.V. Chibalin;P. Burgener-Kairuz

  246
  Citations

• Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology : Accelerated Endocytosis Promotes Late Endocytic Defects

  Anne M. Cataldo;Anne M. Cataldo;Paul M. Mathews;Paul M. Mathews;Anne Boyer Boiteau;Linda C. Hassinger

  228
  Citations

• Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.

  Dun Sheng Yang;Anurag Tandon;Fusheng Chen;Gang Yu

  208
  Citations

• Binding of cystatin C to Alzheimer’s amyloid β inhibits in vitro amyloid fibril formation

  Magdalena Sastre;Miguel Calero;Monika Pawlik;Monika Pawlik;Paul M Mathews;Paul M Mathews

  205
  Citations