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David Westaway

David Westaway

D-Index & Metrics

Neuroscience

D-Index
83
Citations
34796
World Ranking
1419
National Ranking
77

Biology and Biochemistry

D-Index
83
Citations
34930
World Ranking
3433
National Ranking
106

Overview

David Westaway is affiliated with the University of Alberta in Canada. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a significant focus on medicine. Subfields in which Westaway has substantial contributions include molecular biology, physiology, neurology, nutrition and dietetics, and computational theory and mathematics.

The scientist's work addresses topics such as prion diseases and protein misfolding, Alzheimer's disease research and treatments, neurological diseases and metabolism, neuroinflammation and neurodegeneration mechanisms, RNA research and splicing, nuclear structure and function, and RNA regulation and disease.

Westaway has published in various scientific venues, frequently contributing to Acta Neuropathologica, the Journal of Alzheimer's Disease, Molecular Neurobiology, Research Square, and bioRxiv from Cold Spring Harbor Laboratory.

Recent publications by Westaway include the following papers:

  • Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer's disease (2022), Science Translational Medicine
  • Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against β-amyloid-toxicity (2020), Neuropathology and Applied Neurobiology
  • Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope (2021), BMC Biology
  • Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation (2020), Acta Neuropathologica
  • Prion-like strain effects in tauopathies (2022), Cell and Tissue Research

The scientist has collaborated frequently with several co-authors, including Sang-Gyun Kang, Jiri Safar, Serene Wohlgemuth, Zhuang Zhuang Han, and Jing Yang. These collaborations reflect an extensive network within neuroscience and molecular pathology fields.

Best Publications

  • Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

    Christopher Janus;Jacqueline Pearson;JoAnne McLaurin;Paul M. Mathews

  • A cellular gene encodes scrapie PrP 27-30 protein

    Bruno Oesch;Bruno Oesch;David Westaway;Monika Wälchli;Monika Wälchli;Michael P. McKinley

  • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

    Martin Citron;David Westaway;Weiming Xia;George Carlson

  • The cellular prion protein binds copper in vivo

    D R Brown;K Qin;J W Herms;A Madlung

  • Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

    Ju Hyun Lee;Ju Hyun Lee;W. Haung Yu;W. Haung Yu;Asok Kumar;Asok Kumar;Sooyeon Lee;Sooyeon Lee

  • Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

    M. Azhar Chishti;Dun-Shen Yang;Christopher Janus;Amie L. Phinney

  • Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

    K. Basler;B. Oesch;M. Scott;D. Westaway

  • Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

    Stanley B. Prusiner;Michael Scott;Dallas Foster;Keh-Ming Pan

  • Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome

    Karen Hsiao;Harry F. Baker;Tim J. Crow;Mark Poulter

  • Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

    Michael Scott;Dallas Foster;Carol Mirenda;Dan Serban

  • Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

    Raymond H. Kim;Patrice D. Smith;Hossein Aleyasin;Shawn Hayley

  • Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.

    R. C. Moore;I. Y. Lee;G. L. Silverman;P. M. Harrison

  • Distinct prion proteins in short and long scrapie incubation period mice

    David Westaway;Patricia A. Goodman;Carol A. Mirenda;Michael P. McKinley

  • Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4−10 and inhibit cytotoxicity and fibrillogenesis

    J McLaurin;R Cecal;M E Kierstead;X Tian

  • Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

    Dun Sheng Yang;Dun Sheng Yang;Philip Stavrides;Panaiyur S. Mohan;Panaiyur S. Mohan;Susmita Kaushik

  • Linkage of prion protein and scrapie incubation time genes

    George A. Carlson;David T. Kingsbury;Patricia A. Goodman;Sherrie Coleman

  • Interactions between β-amyloid and central cholinergic neurons: Implications for Alzheimer's disease.

    Satyabrata Kar;Stephen P.M. Slowikowski;David Westaway;Howard T.J. Mount

  • Molecular cloning of a human prion protein cDNA.

    Hans A. Kretzschmar;Linda E. Stowring;David Westaway;William H. Stubblebine

  • Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

    Jo Anne McLaurin;Meredith E. Kierstead;Mary E. Brown;Cheryl A. Hawkes

  • TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

    Fusheng Chen;Hiroshi Hasegawa;Hiroshi Hasegawa;Gerold Schmitt-Ulms;Toshitaka Kawarai

  • Transgenic mouse models of Alzheimer's disease.

    Christopher Janus;David Westaway

Frequent Co-Authors

Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Paul E. Fraser
Paul E. Fraser University of Toronto
George A. Carlson
George A. Carlson University of California, San Francisco
Jack H. Jhamandas
Jack H. Jhamandas University of Alberta
Paul M. Mathews
Paul M. Mathews New York University
Stanley B. Prusiner
Stanley B. Prusiner University of California, San Francisco
Ralph A. Nixon
Ralph A. Nixon Nathan Kline Institute for Psychiatric Research
P. H. St George-Hyslop
P. H. St George-Hyslop University of Toronto
Stephen D. Schmidt
Stephen D. Schmidt National Institutes of Health
Ekaterina Rogaeva
Ekaterina Rogaeva University of Toronto

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