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Neuroscience

D-Index
120
Citations
55811
World Ranking
384
National Ranking
228

Overview

Todd E. Golde is affiliated with Emory University in the United States and has an extensive record of research in medical and molecular biology fields, particularly focusing on neurodegenerative diseases. Their work encompasses a broad spectrum of investigations centered on Alzheimer's disease, neuroinflammation, genetics, and cellular neuroscience.

Their recent publications include studies such as "Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation" (2020, Nature Medicine), "Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models" (2020, Cell Reports), "Targeting Notch in oncology: the path forward" (2020, Nature Reviews Drug Discovery), "Neuroinflammation in Alzheimer disease" (2024, Nature Reviews Immunology), and "Do infections have a role in the pathogenesis of Alzheimer disease?" (2020, Nature Reviews Neurology).

Frequent co-authors in their work include:

  • Nilüfer Ertekin-Taner
  • Yona Levites
  • Allan I. Levey
  • Mariet Allen
  • Dennis W. Dickson

The main publication venues for Todd E. Golde's research are:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Neurodegeneration
  • Alzheimer s Research & Therapy
  • Proceedings of the National Academy of Sciences

The scientist's primary fields of study encompass:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Subfields of particular focus within those broader domains include:

  • Physiology
  • Molecular Biology
  • Neurology
  • Genetics
  • Cellular and Molecular Neuroscience

Todd E. Golde's research covers several main topics, including:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Bioinformatics and Genomic Networks
  • Tryptophan and brain disorders
  • Dementia and Cognitive Impairment Research
  • Prion Diseases and Protein Misfolding
  • Virus-based gene therapy research

Best Publications

  • Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction

    Salvatore Oddo;Antonella Caccamo;Jason D. Shepherd;M. Paul Murphy

  • An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants

    Nobuhiro Suzuki;Tobun T. Cheung;Xiao Dan Cai;Asano Odaka

  • Production of the Alzheimer amyloid β protein by normal proteolytic processing

    Mikio Shoji;Todd E. Golde;Jorge Ghiso;Tobun T. Cheung

  • A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

    Sascha Weggen;Jason L. Eriksen;Pritam Das;Sarah A. Sagi

  • Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

    Xiao Dan Cai;Todd E. Golde;Steven G. Younkin

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

    Chang-Yuan Ni;M. Paul Murphy;Todd E. Golde;Graham Carpenter

  • Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

    Erik C.B. Johnson;Eric B. Dammer;Duc M. Duong;Lingyan Ping

  • Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.

    Todd E. Golde;Steven Estus;Linda H. Younkin;Dennis J. Selkoe

  • The secretases: enzymes with therapeutic potential in Alzheimer disease

    Bart De Strooper;Robert Vassar;Todd Golde

  • NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

    Jason L. Eriksen;Sarah A. Sagi;Tawnya E. Smith;Sascha Weggen

  • Aberrant Cleavage of TDP-43 Enhances Aggregation and Cellular Toxicity

    Yong Jie Zhang;Ya Fei Xu;Casey Cook;Tania F. Gendron

  • Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice

    Eileen McGowan;Fiona Pickford;Jungsu Kim;Luisa Onstead

  • Animal models of neurodegenerative diseases.

    Ted M. Dawson;Todd E. Golde;Clotilde Lagier-Tourenne

  • Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

    Todd E. Golde;Steven Estus;Marianne Usiak;Linda H. Younkin

  • Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

    Suzanne Wahrle;Pritam Das;Andrew C. Nyborg;Chris McLendon

  • Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.

    Steven Estus;Todd E. Golde;Tatsuhide Kunishita;Deborah Blades

  • Targeting Notch to target cancer stem cells.

    Antonio Pannuti;Kimberly Foreman;Paola Rizzo;Clodia Osipo

  • Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

    Mariet Allen;Minerva M. Carrasquillo;Cory Funk;Benjamin D. Heavner

  • Rational targeting of Notch signaling in cancer.

    P Rizzo;C Osipo;K Foreman;T Golde

  • Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

    Todd E. Golde;Lon S. Schneider;Edward H. Koo

  • Aβ40 Inhibits Amyloid Deposition In Vivo

    Jungsu Kim;Luisa Onstead;Suzanne Randle;Robert Price

  • Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer’s disease

    Todd E Golde;Christopher B Eckman;Steven G Younkin

  • Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition

    Paramita Chakrabarty;Karen Jansen-West;Amanda Beccard;Carolina Ceballos-Diaz

  • IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

    Paramita Chakrabarty;Andrew Li;Carolina Ceballos-Diaz;James A. Eddy

Frequent Co-Authors

Allan I. Levey
Allan I. Levey Emory University
Joshua M. Shulman
Joshua M. Shulman Baylor College of Medicine
David A. Loewenstein
David A. Loewenstein University of Miami
Steven T. DeKosky
Steven T. DeKosky University of Florida
David A. Bennett
David A. Bennett Rush University Medical Center
David E. Vaillancourt
David E. Vaillancourt University of Florida
Mike Hutton
Mike Hutton Eli Lilly (United States)
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Rudolph E. Tanzi
Rudolph E. Tanzi Harvard University

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