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Medicine

D-Index
125
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64971
World Ranking
3064
National Ranking
1693

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Frank M. LaFerla is affiliated with the University of California, Irvine in the United States. The main fields of study in their research include Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience, with a focus on key subfields such as Physiology, Molecular Biology, Neurology, Pharmacology, and Immunology.

The scientist's work primarily covers several major topics related to neurodegenerative diseases and molecular mechanisms. These topics include:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cholinesterase and Neurodegenerative Diseases
  • CRISPR and Genetic Engineering
  • Computational Drug Discovery Methods
  • Bioinformatics and Genomic Networks
  • Tryptophan and brain disorders

Recent publications by Frank M. LaFerla illustrate ongoing research in Alzheimer's disease models and mechanisms, as shown by these representative papers:

  • Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease, 2021, Scientific Data
  • Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease, 2022, Frontiers in Neuroscience
  • Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD, 2020, Alzheimer s & Dementia Translational Research & Clinical Interventions
  • Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology, 2021, Nature Communications
  • miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease, 2020, Aging Cell

The venues where the scientist frequently publishes research include:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Molecular Neurodegeneration
  • Alzheimer s Research & Therapy

Frank M. LaFerla collaborates often with several co-authors, including:

  • Celia Da Cunha
  • Andrea J. Tenner
  • Grant R. MacGregor
  • Kim N. Green
  • Stefânia Forner

In recognition of their contributions to scientific research, Frank M. LaFerla was made a Fellow of the American Association for the Advancement of Science (AAAS) in 2010.

Best Publications

  • Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction

    Salvatore Oddo;Antonella Caccamo;Jason D. Shepherd;M. Paul Murphy

  • Intracellular amyloid-β in Alzheimer's disease

    Frank M. LaFerla;Kim N. Green;Salvatore Oddo

  • Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

    Lauren M. Billings;Salvatore Oddo;Kim N. Green;James L. McGaugh

  • Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

    Frank M. LaFerla

  • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

    Salvatore Oddo;Antonella Caccamo;Masashi Kitazawa;Bertrand P. Tseng

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.

    Mathew Blurton-Jones;Masashi Kitazawa;Hilda Martinez-Coria;Nicholas A. Castello

  • Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

    Salvatore Oddo;Lauren Billings;J.Patrick Kesslak;David H. Cribbs

  • Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.

    Kim N. Green;Lauren M. Billings;Benno Roozendaal;James L. McGaugh

  • Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

    Masashi Kitazawa;Salvatore Oddo;Tritia R. Yamasaki;Kim N. Green

  • The Alzheimer's A Beta Peptide Induces Neurodegeneration and Apoptotic Cell Death in Transgenic Mice

    Frank M. LaFerla;Brad T. Tinkle;Charles J. Bieberich;Christian C. Haudenschild

  • Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

    Robert A. Rissman;Wayne W. Poon;Mathew Blurton-Jones;Salvatore Oddo

  • Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

    Mark P Mattson;Frank M LaFerla;Sic L Chan;Malcolm A Leissring

  • Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease.

    Veerendra Kumar Madala Halagappa;Zhihong Guo;Michelle Pearson;Yasuji Matsuoka

  • Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

    Martin Fuhrmann;Tobias Bittner;Christian K E Jung;Steffen Burgold

  • Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.

    Lani K. Clinton;Mathew Blurton-Jones;Kristoffer Myczek;John Q. Trojanowski

  • Alzheimer's disease: Aβ, tau and synaptic dysfunction

    Frank M. LaFerla;Salvatore Oddo

  • Animal Models of Alzheimer Disease

    Frank M. LaFerla;Kim N. Green

  • Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease: A link between Aβ and tau pathology

    Salvatore Oddo;Antonella Caccamo;Levina Tran;Mary P. Lambert

  • M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice

    Antonella Caccamo;Salvatore Oddo;Lauren M. Billings;Kim N. Green

Frequent Co-Authors

Salvatore Oddo
Salvatore Oddo Arizona State University
Kim N. Green
Kim N. Green University of California, Irvine
Antonella Caccamo
Antonella Caccamo University of Messina
Mathew Blurton-Jones
Mathew Blurton-Jones University of California, Irvine
David H. Cribbs
David H. Cribbs University of California, Irvine
Ian Parker
Ian Parker University of California, Irvine
Andrea J. Tenner
Andrea J. Tenner University of California, Irvine
Carl W. Cotman
Carl W. Cotman University of California, Irvine
Todd E. Golde
Todd E. Golde Emory University
Margaret A. Pericak-Vance
Margaret A. Pericak-Vance University of Miami

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