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Molecular Biology

D-Index
92
Citations
32102
World Ranking
700
National Ranking
381

Research.com Recognitions

  • 2020 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

P. Hemachandra Reddy is affiliated with Texas Tech University Health Sciences Center in the United States. Their research spans a broad range of topics within medicine, biochemistry, genetics, and molecular biology, with a specific focus on neurodegenerative diseases and mitochondrial pathology.

The primary fields of study for this researcher include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, they have made significant contributions to several subfields:

  • Molecular Biology
  • Physiology
  • Neurology
  • Psychiatry and Mental Health
  • Cancer Research

The main research topics that characterize their work are as follows:

  • Alzheimer's disease research and treatments
  • Mitochondrial Function and Pathology
  • Autophagy in Disease and Therapy
  • Dementia and Cognitive Impairment Research
  • Cholinesterase and Neurodegenerative Diseases
  • Tryptophan and Brain Disorders
  • MicroRNA in Disease Regulation

Frequent co-authors collaborating with Reddy include:

  • Arubala P. Reddy
  • Sudhir Kshirsagar
  • Jangampalli Adi Pradeepkiran
  • Jasvinder Singh Bhatti
  • Gurjit Kaur Bhatti

Most of their work has been published in these venues:

  • Ageing Research Reviews
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  • International Journal of Molecular Sciences
  • Cells
  • Journal of Alzheimer's Disease Reports

Selected recent papers authored or co-authored by P. Hemachandra Reddy include:

  • Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives, 2022, Free Radical Biology and Medicine
  • Phosphorylated Tau in Alzheimer's Disease and Other Tauopathies, 2022, International Journal of Molecular Sciences
  • Synaptic basis of Alzheimer's disease: Focus on synaptic amyloid beta, P-tau and mitochondria, 2020, Ageing Research Reviews
  • Defective mitophagy in Alzheimer's disease, 2020, Ageing Research Reviews
  • Amyloid Beta in Aging and Alzheimer's Disease, 2022, International Journal of Molecular Sciences

Throughout their career, they have been recognized through awards such as:

  • Fellow of the American Association for the Advancement of Science (AAAS), awarded in 2020
  • Member of the Association of American Physicians

Best Publications

  • Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

    Maria Manczak;Thimmappa S. Anekonda;Edward Henson;Byung S. Park

  • Mitochondrial dysfunction and oxidative stress in metabolic disorders — A step towards mitochondria based therapeutic strategies

    Jasvinder Singh Bhatti;Jasvinder Singh Bhatti;Gurjit Kaur Bhatti;P. Hemachandra Reddy

  • Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

    P. Hemachandra Reddy;M. Flint Beal

  • Impaired Mitochondrial Dynamics and Abnormal Interaction of Amyloid Beta with Mitochondrial Protein Drp1 in Neurons from Patients with Alzheimer’s Disease: Implications for Neuronal Damage

    Maria Manczak;Marcus J. Calkins;P. Hemachandra Reddy;P. Hemachandra Reddy

  • Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

    Rui Wang;P. Hemachandra Reddy

  • Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

    Marcus J. Calkins;Maria Manczak;Peizhong Mao;Ulziibat Shirendeb

  • Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease ☆

    Subbiah Pugazhenthi;Subbiah Pugazhenthi;Limei Qin;P. Hemachandra Reddy

  • Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.

    Ramesh Kandimalla;Vani Thirumala;P. Hemachandra Reddy

  • Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

    Maria Manczak;Peizhong Mao;Markus J. Calkins;Anda Cornea

  • Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage.

    Maria Manczak;Byung S. Park;Youngsin Jung;P. Hemachandra Reddy

  • Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA

    P. Hemachandra Reddy;Maya Williams;Vinod Charles;Lisa Garrett

  • Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

    Maria Manczak;P. Hemachandra Reddy;P. Hemachandra Reddy

  • Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction.

    P. Hemachandra Reddy;Geethalakshmi Mani;Byung S. Park;Joline Jacques

  • Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease.

    P. Hemachandra Reddy

  • Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease

    P. Hemachandra Reddy;Shannon McWeeney;Byung S. Park;Maria Manczak

  • Mutant Huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

    Ulziibat P. Shirendeb;Marcus J. Calkins;Maria Manczak;Vishwanath Anekonda

  • Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons

    Ravi Rajmohan;P. Hemachandra Reddy

  • Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

    Ulziibat Shirendeb;Arubala P. Reddy;Maria Manczak;Marcus J. Calkins

  • Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics.

    P. Hemachandra Reddy;Raghav Tripathi;Quang Troung;Karuna Tirumala

  • Are mitochondria critical in the pathogenesis of Alzheimer's disease?

    P. Hemachandra Reddy;M. Flint Beal

Frequent Co-Authors

Danilo A. Tagle
Danilo A. Tagle National Institutes of Health
Hiromi Sesaki
Hiromi Sesaki Johns Hopkins University School of Medicine
William O. Whetsell
William O. Whetsell Vanderbilt University Medical Center
Shannon K. McWeeney
Shannon K. McWeeney Oregon Health & Science University
Charles K. Meshul
Charles K. Meshul Oregon Health & Science University
Joseph F. Quinn
Joseph F. Quinn Oregon Health & Science University
Robert Schwarcz
Robert Schwarcz University of Maryland, Baltimore
Kazuhiro Nakamura
Kazuhiro Nakamura Nagoya University
M. Flint Beal
M. Flint Beal Cornell University
Michael S. Levine
Michael S. Levine Princeton University

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