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D-Index & Metrics

Molecular Biology

D-Index
76
Citations
40572
World Ranking
1128
National Ranking
584

Overview

Hiromi Sesaki is affiliated with Johns Hopkins University School of Medicine in the United States and has a research focus concentrated on molecular biology and its related subfields. Their work spans Biochemistry, Genetics and Molecular Biology, with additional contributions to Medicine. Notably, their research encompasses subfields such as Molecular Biology, Epidemiology, Cell Biology, Physiology, and Clinical Biochemistry.

The scientist's research topics include mitochondrial function and pathology, ATP synthase and ATPases research, autophagy in disease and therapy, endoplasmic reticulum stress and disease, RNA modifications and cancer, metabolism and genetic disorders, and PI3K/AKT/mTOR signaling in cancer.

Selected recent papers authored by Hiromi Sesaki cover a range of studies focused on mitochondrial dynamics and energy homeostasis. These include:

  • Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes (2020, Science)
  • Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition (2020, Cell Stem Cell)
  • Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis (2023, Cell Metabolism)
  • C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly (2021, Cell Metabolism)
  • Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation (2022, Hepatology)

Hiromi Sesaki has frequently contributed to the following publication venues:

  • iScience
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Cell Reports
  • Nature Communications

Collaborations are evident in their frequent coauthorship with researchers including Miho Iijima, Daisuke Murata, Tatsuya Yamada, Takashi Kato, and A. Ikeda.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming

    Michael D D. Buck;Michael D D. Buck;David O'Sullivan;Ramon I I. Klein Geltink;Jonathan D D. Curtis

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

    Junko Wakabayashi;Zhongyan Zhang;Nobunao Wakabayashi;Yasushi Tamura

  • Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

    Ken Nakamura;Venu M. Nemani;Farnaz Azarbal;Gaia Skibinski

  • Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

    Mireille Khacho;Alysen Clark;Devon S. Svoboda;Joelle Azzi

  • Division versus Fusion: Dnm1p and Fzo1p Antagonistically Regulate Mitochondrial Shape

    Hiromi Sesaki;Robert E. Jensen

  • Mitochondrial dynamics in neurodegeneration

    Kie Itoh;Ken Nakamura;Miho Iijima;Hiromi Sesaki

  • A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement

    Sylvie Bannwarth;Samira Ait-El-Mkadem;Annabelle Chaussenot;Emmanuelle C. Genin

  • The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species

    Evan A. Bordt;Pascaline Clerc;Brian A. Roelofs;Andrew J. Saladino;Andrew J. Saladino

  • Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

    Yusuke Kageyama;Masahiko Hoshijima;Kinya Seo;Djahida Bedja

  • Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

    Joel S. Riley;Giovanni Quarato;Catherine Cloix;Jonathan Lopez

  • Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors

    Madhavika N. Serasinghe;Shira Y. Wieder;Thibaud T. Renault;Rana Elkholi

  • Mgm1p, a Dynamin-related GTPase, Is Essential for Fusion of the Mitochondrial Outer Membrane

    Hiromi Sesaki;Sheryl M. Southard;Michael P. Yaffe;Robert E. Jensen

  • Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

    Eugenia Trushina;Emirhan Nemutlu;Song Zhang;Trace Christensen

  • Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

    Yu Wang;Hongying An;Ting Liu;Caolitao Qin

  • UGO1 Encodes an Outer Membrane Protein Required for Mitochondrial Fusion

    Hiromi Sesaki;Robert E. Jensen

  • Regulation of mitochondrial fusion and division.

    Kara L. Cerveny;Yasushi Tamura;Zhongyan Zhang;Robert E. Jensen

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

Frequent Co-Authors

Patrick Yu-Wai-Man
Patrick Yu-Wai-Man University of Cambridge
Robert E. Jensen
Robert E. Jensen Johns Hopkins University
Toshiya Endo
Toshiya Endo Kyoto Sangyo University
Alexis Brice
Alexis Brice Institut du Cerveau
David R. Moore
David R. Moore Cincinnati Children's Hospital Medical Center
Kevin M. Ryan
Kevin M. Ryan University of Glasgow
Evelina Gatti
Evelina Gatti Aix-Marseille University
Ted M. Dawson
Ted M. Dawson Johns Hopkins University School of Medicine
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Sergio Lavandero
Sergio Lavandero University of Chile

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