Lawrence P. Kane

What is he best known for?

The fields of study he is best known for:

• Gene
• Immune system
• Cytokine

Lawrence P. Kane mainly focuses on Signal transduction, Cell biology, T cell, CD28 and Protein kinase B. His study focuses on the intersection of Signal transduction and fields such as Phosphorylation with connections in the field of Tyrosine kinase, NFAT, Guanine nucleotide exchange factor and NFATC Transcription Factors. His work carried out in the field of Cell biology brings together such families of science as Interleukin 2, Acquired immune system, Interleukin 12 and Interleukin 3.

Particularly relevant to T-cell receptor is his body of work in T cell. His CD28 study combines topics from a wide range of disciplines, such as Molecular biology and Kinase. His Protein kinase B research includes elements of I-Kappa-B Kinase, Cancer research, PI3K/AKT/mTOR pathway and Kinase activity.

His most cited work include:

• Induction of NF-κB by the Akt/PKB kinase (762 citations)
• Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. (506 citations)
• Signal transduction by the TCR for antigen. (474 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cell biology, T cell, T-cell receptor, Signal transduction and Protein kinase B. His work deals with themes such as Cytotoxic T cell, IL-2 receptor, Receptor and Immune system, which intersect with Cell biology. His research in T cell intersects with topics in Mucin, Kinase and Transmembrane protein.

His T-cell receptor research incorporates elements of Signal transducing adaptor protein, Tyrosine kinase and CD3, CD8, Antigen. His Signal transduction study integrates concerns from other disciplines, such as Molecular biology, Transcription factor, NFAT and Phosphorylation. He combines subjects such as I-Kappa-B Kinase, Cancer research, PI3K/AKT/mTOR pathway and Intracellular with his study of Protein kinase B.

He most often published in these fields:

• Cell biology (62.83%)
• T cell (48.67%)
• T-cell receptor (23.89%)

What were the highlights of his more recent work (between 2017-2021)?

• Cell biology (62.83%)
• T cell (48.67%)
• Effector (14.16%)

In recent papers he was focusing on the following fields of study:

Lawrence P. Kane focuses on Cell biology, T cell, Effector, Immune system and Signal transduction. Lawrence P. Kane does research in Cell biology, focusing on PI3K/AKT/mTOR pathway specifically. The concepts of his T cell study are interwoven with issues in Protein kinase B, CD8 and Cancer research.

In his research, Antigen is intimately related to Immune checkpoint, which falls under the overarching field of Cancer research. His studies in Immune system integrate themes in fields like Myeloid and Glycosyltransferase, Gene, Virulence. The study incorporates disciplines such as Cancer immunotherapy, Lymphocytic choriomeningitis and Co-stimulation in addition to Signal transduction.

Between 2017 and 2021, his most popular works were:

• Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. (57 citations)
• Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted (40 citations)
• Novel Effector Phenotype of Tim-3+ Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients (36 citations)

In his most recent research, the most cited papers focused on:

• Gene
• Immune system
• Cytokine

The scientist’s investigation covers issues in Cell biology, T cell, Antibody, Cancer research and Immunotherapy. PI3K/AKT/mTOR pathway and Protein kinase B are subfields of Cell biology in which his conducts study. His T cell research incorporates themes from Autoimmunity, CD8, Cytokine and Effector.

His studies deal with areas such as Lymphocytic choriomeningitis, Co-stimulation, Signal transduction, Nephritis and Parenchyma as well as Effector. Lawrence P. Kane has researched Antibody in several fields, including Myeloid, Crosstalk, Immune system, Immunity and Mucin. His Cancer research study incorporates themes from Head and neck squamous-cell carcinoma, Antigen, Receptor, Regulation of gene expression and Flow cytometry.