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Immunology

D-Index
80
Citations
28937
World Ranking
1606
National Ranking
802

Overview

Sarah L. Gaffen is affiliated with the University of Pittsburgh in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a significant focus on Immunology, Infectious Diseases, Molecular Biology, Epidemiology, and Periodontics.

The scientist's work concentrates on several main topics including antifungal resistance and susceptibility, immunodeficiency and autoimmune disorders, fungal infections and studies, oral microbiology and periodontitis research, psoriasis treatment and pathogenesis, pediatric health and respiratory diseases, as well as RNA modifications and cancer.

Among their frequent collaborators are Partha S. Biswas, Felix E.Y. Aggor, Bianca M. Coleman, Rami Bechara, and Tiffany C. Taylor.

Sarah L. Gaffen has published in a variety of venues with repeated contributions to The Journal of Immunology, bioRxiv (Cold Spring Harbor Laboratory), Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Science Immunology, and Cell Host & Microbe.

Notable recent publications include:

  • Regulation of host-microbe interactions at oral mucosal barriers by type 17 immunity, 2020, Science Immunology
  • Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis, 2020, Science Immunology
  • The metabolism-modulating activity of IL-17 signaling in health and disease, 2021, The Journal of Experimental Medicine
  • The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis, 2021, Science Immunology
  • IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment, 2022, Immunity

Best Publications

  • Structure and signalling in the IL-17 receptor family.

    Sarah L. Gaffen

  • IL-23 and IL-17 in the establishment of protective pulmonary CD4 + T cell responses after vaccination and during Mycobacterium tuberculosis challenge

    Shabaana A Khader;Guy K Bell;John E Pearl;Jeffrey J Fountain

  • The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

    Sarah L. Gaffen;Renu Jain;Abhishek V. Garg;Daniel J. Cua

  • The IL-17 Family of Cytokines in Health and Disease.

    Mandy J. McGeachy;Daniel J. Cua;Sarah L. Gaffen

  • Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

    Heather R. Conti;Fang Shen;Namrata Nayyar;Eileen Stocum

  • Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease.

    Reiko M Onishi;Sarah L Gaffen;Sarah L Gaffen

  • IL-17 Signaling: The Yin and the Yang

    Nilesh Amatya;Abhishek V. Garg;Sarah L. Gaffen

  • Overview of interleukin-2 function, production and clinical applications.

    Sarah L. Gaffen;Kathleen D. Liu

  • Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

    Shabaana A. Khader;Sarah L. Gaffen;Jay K. Kolls

  • 1,25-Dihydroxyvitamin D 3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A

    Sneha Joshi;Luiz Carlos Pantalena;Xikui K. Liu;Sarah L. Gaffen;Sarah L. Gaffen

  • IL-17 receptor–based signaling and implications for disease

    Xiaoxia Li;Rami Bechara;Junjie Zhao;Mandy J. McGeachy

  • An overview of IL-17 function and signaling.

    Sarah L. Gaffen

  • An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals.

    Jeffrey J. Yu;Matthew J. Ruddy;Grace C. Wong;Cornelia Sfintescu

  • Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor-α Is Mediated by CCAAT/Enhancer-binding Protein Family Members

    Matthew J. Ruddy;Grace C. Wong;Xikui K. Liu;Hiroyasu Yamamoto

  • A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17

    S.L. Gaffen;G. Hajishengallis

  • Th17 Cells in Immunity to Candida albicans

    Nydiaris Hernández-Santos;Sarah L. Gaffen

  • Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy.

    Fang Shen;Sarah L. Gaffen

  • Recent advances in the IL-17 cytokine family

    Sarah L Gaffen

  • Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications.

    Leticia Monin;Sarah L. Gaffen

  • Identification of common transcriptional regulatory elements in interleukin-17 target genes.

    Fang Shen;Zihua Hu;Jaya Goswami;Sarah L. Gaffen

  • Cytokines link osteoblasts and inflammation : microarray analysis of interleukin-17- and TNF-α-induced genes in bone cells

    Fang Shen;Matthew J. Ruddy;Pascale Plamondon;Sarah L. Gaffen

Frequent Co-Authors

Jay K. Kolls
Jay K. Kolls Tulane University
Bernhard Hube
Bernhard Hube Leibniz Association
Julian R. Naglik
Julian R. Naglik King's College London
Ulrich Siebenlist
Ulrich Siebenlist National Institutes of Health
Shabaana A. Khader
Shabaana A. Khader Washington University in St. Louis
Lawrence P. Kane
Lawrence P. Kane University of Pittsburgh
Averil Ma
Averil Ma University of California, San Francisco
Mark A. Goldsmith
Mark A. Goldsmith Revolution Medicines
Scott G. Filler
Scott G. Filler University of California, Los Angeles
Daniel H. Kaplan
Daniel H. Kaplan University of Pittsburgh

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