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Immunology

D-Index
99
Citations
44458
World Ranking
740
National Ranking
421

Medicine

D-Index
99
Citations
44509
World Ranking
8476
National Ranking
4377

Overview

George Hajishengallis is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Immunology and Microbiology, with a significant volume of work also contributing to Medicine. The scientist's investigations focus on several subfields including Immunology, Periodontics, Molecular Biology, Genetics, and Physiology.

The main research topics covered by George Hajishengallis include:

  • Oral microbiology and periodontitis research
  • Immune responses and vaccinations
  • Immune response and inflammation
  • Immune cells in cancer
  • Oral health pathology and treatment
  • Complement system in diseases
  • Immunodeficiency and autoimmune disorders

Among recent scientific contributions, notable papers authored by George Hajishengallis include:

  • Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities, 2021, Nature Reviews. Immunology
  • Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy, 2020, Periodontology 2000
  • Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications, 2022, Periodontology 2000

George Hajishengallis has also coauthored with several researchers repeatedly, including:

  • Triantafyllos Chavakis
  • Xiaofei Li
  • Tetsuhiro Kajikawa
  • Kyoung-Jin Chung
  • Niki M. Moutsopoulos

The venues where George Hajishengallis has frequently published work include:

  • Periodontology 2000
  • The Journal of Immunology
  • Cell
  • Frontiers in Immunology
  • Journal of Clinical Investigation

This profile reflects a body of research that combines fundamental immunological mechanisms with clinical implications in oral health and systemic inflammatory conditions. The scientist's work integrates molecular biology, pathology, and immune system regulation, addressing both local oral diseases and broader immunological comorbidities.

Best Publications

  • Complement: a key system for immune surveillance and homeostasis

    Daniel Ricklin;George Hajishengallis;Kun Yang;John D Lambris

  • Periodontitis: from microbial immune subversion to systemic inflammation

    George Hajishengallis

  • The oral microbiota: dynamic communities and host interactions.

    Richard J. Lamont;Hyun Koo;George Hajishengallis

  • The keystone-pathogen hypothesis

    George Hajishengallis;Richard P. Darveau;Michael A. Curtis

  • Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

    George Hajishengallis;Triantafyllos Chavakis

  • Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology.

    G. Hajishengallis;R.J. Lamont

  • Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

    George Hajishengallis;Shuang Liang;Mark A. Payne;Ahmed Hashim

  • Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response.

    George Hajishengallis

  • Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

    Ioannis Mitroulis;Klara Ruppova;Baomei Wang;Lan Sun Chen

  • TLR-signaling Networks An Integration of Adaptor Molecules, Kinases, and Cross-talk

    Jonathan Brown;Huizhi Wang;George N. Hajishengallis;Michael Martin

  • Polymicrobial synergy and dysbiosis in inflammatory disease

    Richard J. Lamont;George Hajishengallis

  • Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity.

    Lydia Kalafati;Lydia Kalafati;Ioannis Kourtzelis;Ioannis Kourtzelis;Ioannis Kourtzelis;Jonas Schulte-Schrepping;Xiaofei Li

  • Porphyromonas gingivalis as a Potential Community Activist for Disease

    R.P. Darveau;G. Hajishengallis;M.A. Curtis

  • Optimization of the ligature-induced periodontitis model in mice.

    Toshiharu Abe;George Hajishengallis

  • The use of rodent models to investigate host–bacteria interactions related to periodontal diseases

    Dana T. Graves;Daniel Fine;Yen-Tung A. Teng;Thomas E. Van Dyke

  • The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

    Mehmet A Eskan;Ravi Jotwani;Toshiharu Abe;Toshiharu Abe;Jindrich Chmelar

  • Basic biology and role of interleukin‐17 in immunity and inflammation

    Camille Zenobia;George Hajishengallis

  • Novel mechanisms and functions of complement

    George Hajishengallis;Edimara S Reis;Dimitrios C Mastellos;Daniel Ricklin

  • New insights into the immune functions of complement.

    Edimara S. Reis;Dimitrios C. Mastellos;George Hajishengallis;John D. Lambris

  • Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

    Tomoki Maekawa;Jennifer L. Krauss;Toshiharu Abe;Ravi Jotwani

  • A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17

    S.L. Gaffen;G. Hajishengallis

  • The inflammophilic character of the periodontitis‐associated microbiota

    George Hajishengallis

Frequent Co-Authors

John D. Lambris
John D. Lambris University of Pennsylvania
Michael W. Russell
Michael W. Russell University at Buffalo, State University of New York
Suzanne M. Michalek
Suzanne M. Michalek University of Alabama at Birmingham
Daniel Ricklin
Daniel Ricklin University of Basel
Richard J. Lamont
Richard J. Lamont University of Louisville
Niki M. Moutsopoulos
Niki M. Moutsopoulos National Institutes of Health
Michael A. Curtis
Michael A. Curtis King's College London
Fuminobu Yoshimura
Fuminobu Yoshimura Aichi Gakuin University
Tom Eirik Mollnes
Tom Eirik Mollnes Oslo University Hospital

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