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Biology and Biochemistry

D-Index
53
Citations
9193
World Ranking
16255
National Ranking
6732

Overview

Mark A. Goldsmith is affiliated with Revolution Medicines in the United States. Their research spans multiple fields, primarily within biochemistry, genetics, and molecular biology, as well as computer science.

Their work focuses on several subfields, including molecular biology, immunology, computational theory and mathematics, artificial intelligence, and toxicology. The main topics covered by their research include bioinformatics and genomic networks, protein tyrosine phosphatases, quantum-dot cellular automata, machine learning in bioinformatics, galectins and cancer biology, bioactive compounds and antitumor agents, and phagocytosis and immune regulation.

The scientist has published papers in multiple venues with a notable presence in:

  • arXiv (Cornell University)
  • Cancer Research
  • Frontiers in Immunology
  • Journal of Thoracic Oncology
  • Entropy

Some of their recent publications include:

  • Link Prediction with Continuous-Time Classical and Quantum Walks, 2023, Entropy
  • Towards quantum-enabled cell-centric therapeutics, 2023, arXiv (Cornell University)
  • Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment, 2020, Cancer Research
  • Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity, 2020, Frontiers in Immunology
  • A06 Tri-complex Inhibitors of the Oncogenic, GTP-Bound Form of KRASG12C Overcome RTK-Mediated Escape Mechanisms and Drive Tumor Regressions in Preclinical Models of NSCLC, 2020, Journal of Thoracic Oncology

Throughout their career, Mark A. Goldsmith has collaborated frequently with several co-authors, including:

  • Sabrina Maniscalco
  • Mallika Singh
  • Jacqueline A.M. Smith
  • Harto Saarinen
  • David Wildes

Best Publications

  • Multiple Extracellular Elements of CCR5 and HIV-1 Entry: Dissociation from Response to Chemokines

    Robert E. Atchison;Jennifa Gosling;Felipe S. Monteclaro;Christian Franci

  • A Kaposi’s Sarcoma-associated Herpesvirus-encoded Cytokine Homolog (vIL-6) Activates Signaling through the Shared gp130 Receptor Subunit

    Jaime Molden;Yuan Chang;Yun You;Patrick S. Moore

  • Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.

    R F Speck;K Wehrly;E J Platt;R E Atchison

  • RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers.

    Robert J. Nichols;Franziska Haderk;Carlos Stahlhut;Christopher J. Schulze

  • JAK/STAT signaling by cytokine receptors

    Kathleen D Liu;Sarah L Gaffen;Mark A Goldsmith

  • HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues

    Daniel A Eckstein;Michael L Penn;Yael D Korin;Deirdre D Scripture-Adams

  • Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.

    M A Goldsmith;M T Warmerdam;R E Atchison;M D Miller

  • Folate Receptor-α Is a Cofactor for Cellular Entry by Marburg and Ebola Viruses

    Stephen Y. Chan;Cyril J. Empig;Frank J. Welte;Roberto F. Speck

  • An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.

    Oded Livnah;Dana L. Johnson;Enrico A. Stura;Francis X. Farrell

  • Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity

    Jennifa Gosling;Felipe S. Monteclaro;Robert E. Atchison;Hidenori Arai

  • Early signal transduction by the antigen receptor without commitment to T cell activation

    Mark A. Goldsmith;Arthur Weiss

  • STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils

    Athanasia D. Panopoulos;Ling Zhang;Jonathan W. Snow;Daniel M. Jones

  • Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor

    Mark A. Goldsmith;Arthur Weiss

  • Association of the caveola vesicular system with cellular entry by filoviruses.

    Cyril J. Empig;Mark A. Goldsmith

  • Distinct Mechanisms of Entry by Envelope Glycoproteins of Marburg and Ebola (Zaire) Viruses

    Stephen Y. Chan;Roberto F. Speck;Melissa C. Ma;Mark A. Goldsmith

  • HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cells.

    Daniel A. Eckstein;Michael P. Sherman;Michael L. Penn;Peggy S. Chin

  • CXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1-infected human lymphoid tissue

    Michael L. Penn;Jean-Charles Grivel;Birgit Schramm;Mark A. Goldsmith

  • The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.

    Linda K. Bockenstedt;Mark A. Goldsmith;Michael Dustin;Daniel Olive

  • In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells.

    Andreas Jekle;Oliver T. Keppler;Erik De Clercq;Dominique Schols

  • Loss of Tolerance and Autoimmunity Affecting Multiple Organs in STAT5A/5B-Deficient Mice

    Jonathan W. Snow;Ninan Abraham;Melissa C. Ma;Brian G. Herndier

Frequent Co-Authors

Warner C. Greene
Warner C. Greene University of California, San Francisco
Arthur Weiss
Arthur Weiss University of California, San Francisco
Kathleen D. Liu
Kathleen D. Liu University of California, San Francisco
Oliver T. Keppler
Oliver T. Keppler Ludwig-Maximilians-Universität München
Gregory D. Longmore
Gregory D. Longmore Washington University in St. Louis
Israel F. Charo
Israel F. Charo University of California, San Francisco
Brian Herndier
Brian Herndier University of California, San Diego
Robert M. Grant
Robert M. Grant University of California, San Francisco
Sarah L. Gaffen
Sarah L. Gaffen University of Pittsburgh

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