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Biology and Biochemistry

D-Index
67
Citations
12702
World Ranking
8377
National Ranking
613

Overview

Oliver T. Fackler is affiliated with the University Hospital Heidelberg in Germany and has a substantial body of research primarily focused on immunology, microbiology, biochemistry, genetics, molecular biology, and medicine.

The scientist's research spans several subfields, including immunology, molecular biology, virology, infectious diseases, and epidemiology. Through this multidisciplinary approach, they have contributed to understanding immune cell function, viral infections, and immune responses.

Among the main topics of their work are:

  • HIV Research and Treatment
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Cytomegalovirus and herpesvirus research
  • Cell Image Analysis Techniques
  • Immunotherapy and Immune Responses
  • Interferon and Immune Responses

Fackler has frequently published in several scientific venues with notable contributions in journals such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Nature Methods
  • The EMBO Journal
  • EMBO Reports

Recent publications include:

  • "Salivary gland macrophages and tissue-resident CD8 + T cells cooperate for homeostatic organ surveillance", 2020, Science Immunology
  • "SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models", 2022, Cell Reports
  • "Temporal control of the integrated stress response by a stochastic molecular switch", 2022, Science Advances
  • "The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters", 2022, mBio
  • "A Recurrent Neural Network for Particle Tracking in Microscopy Images Using Future Information, Track Hypotheses, and Multiple Detections", 2020, IEEE Transactions on Image Processing

Collaboration is a notable aspect of Fackler's scientific activity, with frequent co-authors including:

  • Bettina Stolp
  • Samy Sid Ahmed
  • Ina Ambiel
  • Oliver T. Keppler
  • Iart Luca Shytaj

This network of collaborators supports a broad and intersecting range of research projects, particularly in immunology and virology.

Best Publications

  • Cell motility through plasma membrane blebbing

    Oliver T. Fackler;Robert Grosse

  • SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

    Hanna Mari Baldauf;Xiaoyu Pan;Elina Erikson;Elina Erikson;Sarah Schmidt

  • Structure–function relationships in HIV-1 Nef

    Matthias Geyer;Oliver T Fackler;B Matija Peterlin

  • Activation of Vav by Nef Induces Cytoskeletal Rearrangements and Downstream Effector Functions

    Oliver T Fackler;Wen Luo;Matthias Geyer;Arthur S Alberts

  • HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor.

    Christine Goffinet;Ina Allespach;Stefanie Homann;Hanna-Mari Tervo

  • Involvement of Clathrin-Mediated Endocytosis in Human Immunodeficiency Virus Type 1 Entry

    Jessica Daecke;Oliver T. Fackler;Matthias T. Dittmar;Hans-Georg Kräusslich

  • Construction and Characterization of a Fluorescently Labeled Infectious Human Immunodeficiency Virus Type 1 Derivative

    Barbara Müller;Jessica Daecke;Oliver T. Fackler;Matthias T. Dittmar

  • Live and Let Die: Nef Functions beyond HIV Replication

    Oliver T Fackler;Andreas S Baur

  • The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.

    Nico Michel;Ina Allespach;Stephanie Venzke;Oliver T. Fackler

  • Nef increases infectivity of HIV via lipid rafts

    Yong Hui Zheng;Ana Plemenitas;Thomas Linnemann;Oliver T. Fackler

  • Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

    Thomas M. Kitzing;Arul S. Sahadevan;Dominique T. Brandt;Helga Knieling

  • Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

    Oliver T Fackler;Andres Alcover;Olivier Schwartz

  • Endocytic entry of HIV-1.

    Oliver T. Fackler;B.Matija Peterlin

  • HIV-1 Nef Interferes with Host Cell Motility by Deregulation of Cofilin

    Bettina Stolp;Michal Reichman-Fried;Libin Abraham;Xiaoyu Pan

  • Restrictions to HIV-1 replication in resting CD4 + T lymphocytes

    Xiaoyu Pan;Hanna Mari Baldauf;Oliver T. Keppler;Oliver T. Fackler

  • p21-activated kinase 1 plays a critical role in cellular activation by Nef.

    Oliver T. Fackler;Xiaobin Lu;Jeffrey A. Frost;Matthias Geyer

  • Mutation of a Conserved Residue (D123) Required for Oligomerization of Human Immunodeficiency Virus Type 1 Nef Protein Abolishes Interaction with Human Thioesterase and Results in Impairment of Nef Biological Functions

    Lang Xia Liu;Nikolaus Heveker;Oliver T. Fackler;Stefan Theodor Arold

  • Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery.

    Matthias Geyer;Haifeng Yu;Robert Mandic;Thomas Linnemann

  • Human Immunodeficiency Virus Type 1 Nef Activates p21-Activated Kinase via Recruitment into Lipid Rafts

    Ellen Krautkrämer;Simone I. Giese;Judith E. Gasteier;Walter Muranyi

  • The HIV-1 Pathogenicity Factor Nef Interferes with Maturation of Stimulatory T-lymphocyte Contacts by Modulation of N-Wasp Activity

    Claudia Haller;Susanne Rauch;Nico Michel;Sebastian Hannemann

Frequent Co-Authors

Oliver T. Keppler
Oliver T. Keppler Ludwig-Maximilians-Universität München
Matthias Geyer
Matthias Geyer University of Bonn
Hans-Georg Kräusslich
Hans-Georg Kräusslich Heidelberg University
Ralf Bartenschlager
Ralf Bartenschlager Heidelberg University
Frank Kirchhoff
Frank Kirchhoff University of Ulm
Robert Grosse
Robert Grosse University of Freiburg
Serge Benichou
Serge Benichou Grenoble Alpes University
B. Matija Peterlin
B. Matija Peterlin University of California, San Francisco
Nikolaus Mueller-Lantzsch
Nikolaus Mueller-Lantzsch Saarland University
Paul Jolicoeur
Paul Jolicoeur University of Montreal

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