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Biology and Biochemistry

D-Index
60
Citations
11321
World Ranking
12084
National Ranking
933

Overview

Tom P. Fleming is affiliated with the University of Southampton in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Pediatrics, Perinatology and Child Health, Molecular Biology, Public Health, Environmental and Occupational Health, Obstetrics and Gynecology, and Surgery.

The topics they investigate cover Birth, Development, and Health; Reproductive Biology and Fertility; Renal and related cancers; Prenatal Screening and Diagnostics; Pluripotent Stem Cells Research; Assisted Reproductive Technology and Twin Pregnancy; and Pregnancy and preeclampsia studies.

Recent papers authored or co-authored by Tom P. Fleming include:

  • The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring, 2020, Human Reproduction
  • Environmental Exposures around Conception: Developmental Pathways Leading to Lifetime Disease Risk, 2021, International Journal of Environmental Research and Public Health
  • The mammalian preimplantation embryo: Its role in the environmental programming of postnatal health and performance, 2023, Animal Reproduction Science
  • High maternal folic acid intake around conception alters mouse blastocyst lineage allocation and expression of key developmental regulatory genes, 2021, Molecular Reproduction and Development
  • Preimplantation or gestation/lactation high-fat diet alters adult offspring metabolism and neurogenesis, 2023, Brain Communications

Frequent co-authors collaborating with Tom P. Fleming include:

  • Judith J. Eckert (8 publications)
  • Neil Smyth (5 publications)
  • Miguel A. Velazquez (4 publications)
  • Adam J. Watkins (3 publications)
  • Pooja Khurana (3 publications)

Tom P. Fleming's work has been published in various academic venues, with multiple contributions appearing in the Journal of Developmental Origins of Health and Disease (2 publications), along with works in Human Reproduction, the International Journal of Environmental Research and Public Health, Animal Reproduction Science, and Molecular Reproduction and Development.

Best Publications

  • Origins of lifetime health around the time of conception: causes and consequences.

    Tom P Fleming;Adam J Watkins;Miguel A Velazquez;John C Mathers

  • Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension.

    Wing Yee Kwong;Arthur E. Wild;Paul Roberts;Antony C. Willis

  • Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes.

    Natalia Igosheva;Andrey Y. Abramov;Lucilla Poston;Judith J. Eckert

  • The Embryo and Its Future

    Tom P. Fleming;Wing Yee Kwong;Richard Porter;Elizabeth Ursell

  • A quantitative analysis of cell allocation to trophectoderm and inner cell mass in the mouse blastocyst.

    Tom P. Fleming

  • Adaptive Responses by Mouse Early Embryos to Maternal Diet Protect Fetal Growth but Predispose to Adult Onset Disease

    Adam J. Watkins;Elizabeth Ursell;Rose Panton;Thomas Papenbrock

  • From egg to epithelium.

    Tom P. Fleming;Martin H. Johnson

  • Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure

    Adam J. Watkins;Duncan Platt;Tom Papenbrock;Adrian Wilkins

  • Identification of a tight junction–associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability

    Gaëlle Benais-Pont;Anu Punn;Catalina Flores-Maldonado;Judith Eckert

  • The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells.

    Sarah Wallis;Susan Lloyd;Irene Wise;Grenham Ireland

  • Cell adhesion in the preimplantation mammalian embryo and its role in trophectoderm differentiation and blastocyst morphogenesis.

    T P Fleming;B Sheth;I Fesenko

  • Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring

    Adam Watkins;Adrian Wilkins;Colm Cunningham;V. Hugh Perry

  • Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 alpha+ isoform.

    Bhavwanti Sheth;Ira Fesenko;Jane E. Collins;Breda Moran

  • Development of tight junctions de novo in the mouse early embryo: control of assembly of the tight junction-specific protein, ZO-1.

    T P Fleming;J McConnell;M H Johnson;B R Stevenson

  • Desmosome biogenesis in the mouse preimplantation embryo

    T.P. Fleming;D.R. Garrod;A.J. Elsmore

  • Tight junction biogenesis during early development

    Judith J. Eckert;Tom P. Fleming

  • Imprinted gene expression in the rat embryo–fetal axis is altered in response to periconceptional maternal low protein diet

    Wing Yee Kwong;Daniel J Miller;Elizabeth Ursell;Arthur E Wild

  • Trophectodermal processes regulate the expression of totipotency within the inner cell mass of the mouse expanding blastocyst.

    Tom P. Fleming;Paul D. Warren;Julia C. Chisholm;Martin H. Johnson

  • Assembly of tight junctions during early vertebrate development.

    Tom P. Fleming;Tom Papenbrock;Irina Fesenko;Irina Fesenko;Peter Hausen

  • Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo.

    Fay C. Thomas;Bhavwanti Sheth;Judith J. Eckert;Gianfranco Bazzoni

Frequent Co-Authors

Mark A. Hanson
Mark A. Hanson University of Southampton
Clive Osmond
Clive Osmond University of Southampton
Neil Smyth
Neil Smyth University of Southampton
Mary Barker
Mary Barker University of Southampton
Keith M. Godfrey
Keith M. Godfrey University of Southampton
Sandra Citi
Sandra Citi University of Geneva
Peter D. Gluckman
Peter D. Gluckman University of Auckland
Henry J. Leese
Henry J. Leese Hull York Medical School
Colm Cunningham
Colm Cunningham Trinity College Dublin
Martin H. Johnson
Martin H. Johnson University of Cambridge

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