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Neuroscience

D-Index
69
Citations
16537
World Ranking
2637
National Ranking
148

Overview

Lynn A. Raymond is affiliated with the University of British Columbia in Canada. Their research primarily focuses on neurological and molecular aspects of diseases, with a strong emphasis on genetic neurodegenerative conditions.

The main fields of study in which Lynn A. Raymond is active include:

  • Neuroscience
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broader fields, their subfields of specialization are:

  • Cellular and Molecular Neuroscience
  • Neurology
  • Molecular Biology
  • Cognitive Neuroscience
  • Pharmacology

The major topics covered by Lynn A. Raymond's research include:

  • Genetic Neurodegenerative Diseases
  • Neurological disorders and treatments
  • Mitochondrial Function and Pathology
  • Neuroscience and Neuropharmacology Research
  • Motor Control and Adaptation
  • Cannabis and Cannabinoid Research
  • Axon Guidance and Neuronal Signaling

Lynn A. Raymond has frequently collaborated with several researchers, including:

  • Marja D. Sepers
  • James P. Mackay
  • Daniel Ramandi
  • Timothy H. Murphy
  • Ellen T. Koch

Their publication record spans multiple venues, with repeated contributions to the following journals and platforms:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neurobiology of Disease
  • Journal of Huntington's Disease
  • The Lancet Neurology
  • Nature Medicine

Notable recent papers authored by or associated with Lynn A. Raymond include:

  • "Safety and efficacy of valbenazine for the treatment of chorea associated with Huntington's disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial" (2023), The Lancet Neurology
  • "Pepinemab antibody blockade of SEMA4D in early Huntington's disease: a randomized, placebo-controlled, phase 2 trial" (2022), Nature Medicine
  • "Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study" (2024), The Lancet Neurology
  • "Water-Reaching Platform for Longitudinal Assessment of Cortical Activity and Fine Motor Coordination Defects in a Huntington Disease Mouse Model" (2023), eNeuro
  • "Early Changes in Striatal Activity and Motor Kinematics in a Huntington's Disease Mouse Model" (2022), Movement Disorders

Best Publications

  • Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

    Rona K. Graham;Yu Deng;Elizabeth J. Slow;Brendan Haigh

  • Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease.

    Melinda M Zeron;Oskar Hansson;Nansheng Chen;Cheryl L Wellington

  • A Calcium-Dependent Feedback Mechanism Participates in Shaping Single NMDA Miniature EPSCs

    Masashi Umemiya;Nansheng Chen;Lynn A. Raymond;Timothy H. Murphy

  • Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice.

    Austen J. Milnerwood;Clare M. Gladding;Mahmoud A. Pouladi;Alexandra M. Kaufman

  • Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

    Matthew P. Parsons;Lynn A. Raymond

  • N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease.

    Mannie M Y Fan;Lynn A Raymond

  • Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.

    Anat Yanai;Kun Huang;Rujun Kang;Roshni R Singaraja

  • Regulation of ligand-gated ion channels by protein phosphorylation.

    S L Swope;S J Moss;L A Raymond;R L Huganir

  • Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

    Austen J. Milnerwood;Lynn A. Raymond

  • Pathophysiology of Huntington’s Disease: Time-Dependent Alterations in Synaptic and Receptor Function

    Lynn A. Raymond;Véronique M. André;Carlos Cepeda;Clare M. Gladding

  • Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase

    Lynn A. Raymond;Craig D. Blackstone;Richard L. Huganir

  • Phosphorylation of amino acid neurotransmitter receptors in synaptic plasticity.

    Lynn A. Raymond;Craig D. Blackstone;Richard L. Huganir

  • Subtype-dependence of NMDA receptor channel open probability.

    Nansheng Chen;Tao Luo;Lynn A. Raymond

  • Differential Sensitivity of RecombinantN-Methyl-d-Aspartate Receptor Subtypes to Zinc Inhibition

    Nansheng Chen;Ali Moshaver;Lynn A. Raymond

  • Mutant huntingtin enhances excitotoxic cell death.

    Melinda M. Zeron;Nansheng Chen;Ali Moshaver;Allen Ting-Chun Lee

  • Wild-type huntingtin protects neurons from excitotoxicity.

    Blair R. Leavitt;Jeremy M. van Raamsdonk;Jacqueline Shehadeh;Herman Fernandes

  • Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function

    Clare M. Gladding;Lynn A. Raymond

  • Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.

    Nansheng Chen;Tao Luo;Cheryl Wellington;Martina Metzler

  • Differential regulation of synaptic and extra-synaptic NMDA receptors

    Bo Li;Nansheng Chen;Tao Luo;Yo Otsu

  • Selective neuronal degeneration in Huntington's disease

    Catherine M Cowan;Lynn A Raymond

Frequent Co-Authors

Blair R. Leavitt
Blair R. Leavitt University of British Columbia
Timothy H. Murphy
Timothy H. Murphy University of British Columbia
Karen Marder
Karen Marder Columbia University
Jane S. Paulsen
Jane S. Paulsen University of Wisconsin–Madison
Rona K. Graham
Rona K. Graham Université de Sherbrooke
Jeffrey D. Long
Jeffrey D. Long University of Iowa
Richard L. Huganir
Richard L. Huganir Johns Hopkins University School of Medicine
Elizabeth Aylward
Elizabeth Aylward Seattle Children's Hospital
Jody Corey-Bloom
Jody Corey-Bloom University of California, San Diego
Anne Elizabeth Rosser
Anne Elizabeth Rosser Cardiff University

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