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Neuroscience

D-Index
47
Citations
12030
World Ranking
6331
National Ranking
370

Overview

Rona K. Graham is affiliated with the Université de Sherbrooke in Canada. Their primary field of study is neuroscience, with a focus on sensory and neurological systems and nutrition.

The scientist's research explores various subfields within neuroscience, including sensory systems, nutrition and dietetics, neurology, biomedical engineering, and cellular and molecular neuroscience.

Their core topics of work include olfactory and sensory function studies, biochemical analysis and sensing techniques, advanced chemical sensor technologies, neurological disease mechanisms and treatments, fatty acid research and health, memory and neural mechanisms, and neuroinflammation and neurodegeneration mechanisms.

Notable recent publications by Rona K. Graham include:

  • Volumetric MRI Demonstrates Atrophy of the Olfactory Cortex in AD, 2021, Current Alzheimer Research
  • Early deficits in olfaction are associated with structural and molecular alterations in the olfactory system of a Huntington disease mouse model, 2020, Human Molecular Genetics
  • Olfactory Dysfunction Associated with Cognitive Decline in an Elderly Population, 2022, Experimental Aging Research
  • Amelioration of Cognitive and Olfactory System Deficits in APOE4 Transgenic Mice with DHA Treatment, 2023, Molecular Neurobiology
  • Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice, 2021, European Journal of Neuroscience

Frequent coauthors collaborating with Graham include:

  • Mélissa Lessard-Beaudoin
  • Majed AlOtaibi
  • Raphaël Chouinard-Watkins
  • Mélanie Plourde
  • Frédéric Calon

Common venues for Graham's publications are:

  • Alzheimer s & Dementia
  • Current Alzheimer Research
  • Experimental Aging Research
  • Molecular Neurobiology
  • Human Molecular Genetics

Best Publications

  • The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

    Unknown

  • Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

    Elizabeth J. Slow;Jeremy van Raamsdonk;Daniel Rogers;Sarah H. Coleman

  • Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

    Rona K. Graham;Yu Deng;Elizabeth J. Slow;Brendan Haigh

  • Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.

    Y.P. Goldberg;D.W. Nicholson;D.M. Rasper;M.A. Kalchman

  • Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice.

    Austen J. Milnerwood;Clare M. Gladding;Mahmoud A. Pouladi;Alexandra M. Kaufman

  • Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

    Maya Saleh;John P. Vaillancourt;Rona K. Graham;Matthew Huyck

  • Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

    Shu-ichi Okamoto;Mahmoud A Pouladi;Maria Talantova;Dongdong Yao

  • Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

    Cheryl L. Wellington;Lisa M. Ellerby;Claire-Anne Gutekunst;Danny Rogers

  • HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.

    Kalchman Ma;Koide Hb;McCutcheon K;Graham Rk

  • Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating Enzyme

    Michael A. Kalchman;Rona K. Graham;Gang Xia;H. Brook Koide

  • Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

    Elizabeth J. Slow;Rona K. Graham;Alexander P. Osmand;Rebecca S. Devon

  • Molecular analysis of new mutations for Huntington's disease: intermediate alleles and sex of origin effects

    Y P Goldberg;B Kremer;S E Andrew;J Theilmann

  • Wild-type huntingtin protects neurons from excitotoxicity.

    Blair R. Leavitt;Jeremy M. van Raamsdonk;Jacqueline Shehadeh;Herman Fernandes

  • Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.

    Paolo Guidetti;Gillian P. Bates;Rona K. Graham;Michael R. Hayden

  • Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease

    Chuan En Wang;Suzanne Tydlacka;Adam L. Orr;Shang Hsun Yang

  • Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.

    Mahmoud A Pouladi;Rona K Graham;Rona K Graham;Joanna M Karasinska;Joanna M Karasinska;Yuanyun Xie;Yuanyun Xie

  • Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells

    Tamara Ratovitski;Marjan Gucek;Haibing Jiang;Ekaterine Chighladze

  • Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease.

    Jacqueline Shehadeh;Herman B. Fernandes;Melinda M. Zeron Mullins;Rona K. Graham

  • Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

    Simon C. Warby;Crystal N. Doty;Rona K. Graham;Jeffrey B. Carroll

  • Absence of Disease Phenotype and Intergenerational Stability of the Cag Repeat in Transgenic Mice Expressing the Human Huntington Disease Transcript

    Y. P. Goldberg;M. A. Kalchman;M. Metzler;J. Nasir

  • Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.

    Hua Zhang;Qin Li;Rona K. Graham;Elizabeth Slow

Frequent Co-Authors

Blair R. Leavitt
Blair R. Leavitt University of British Columbia
Lynn A. Raymond
Lynn A. Raymond University of British Columbia
Johanna M. Rommens
Johanna M. Rommens University of Toronto
Frédéric Calon
Frédéric Calon Université Laval
Olaf Riess
Olaf Riess University of Tübingen
Stuart A. Lipton
Stuart A. Lipton Scripps Research Institute
Stephen C. Cunnane
Stephen C. Cunnane Université de Sherbrooke
Gillian P. Bates
Gillian P. Bates University College London
Bernhard H. F. Weber
Bernhard H. F. Weber University of Regensburg
Xiao-Jiang Li
Xiao-Jiang Li Jinan University

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