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Biology and Biochemistry

D-Index
73
Citations
32324
World Ranking
5798
National Ranking
130

Overview

Silvio Bicciato is affiliated with the University of Modena and Reggio Emilia in Italy. Their research focuses broadly on biochemical, genetic, and molecular biology topics, with a significant emphasis on medicine and immunology. The scientist's work spans various subfields, including molecular biology, immunology, oncology, cell biology, and cancer research.

Their research topics cover multiple specialized areas:

  • Immune Cell Function and Interaction
  • Cancer Immunotherapy and Biomarkers
  • Immune cells in cancer
  • Hippo pathway signaling and YAP/TAZ
  • Single-cell and spatial transcriptomics
  • Immunotherapy and Immune Responses
  • RNA Research and Splicing

Bicciato has contributed to several recent papers, with publications appearing in notable journals such as Nature and Nature Communications. Their recent papers include:

  • "YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING," published in 2022 in Nature
  • "Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties," published in 2020 in Nature Materials
  • "Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in glioblastoma," published in 2020 in Nature Cancer
  • "Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ," published in 2021 in Nature Communications
  • "Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome," published in 2020 in Nature Communications

Frequent co-authors appear regularly in Bicciato's publications, indicating collaborative research ties with colleagues such as Mattia Forcato, Andrea Grilli, Oriana Romano, Claudio Tripodo, and Stefano Piccolo.

In terms of publication venues, Bicciato's work is frequently published in:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Journal of Experimental & Clinical Cancer Research
  • Nature Materials

The scope of research conducted by Silvio Bicciato bridges molecular and cellular biology with clinical applications in oncology and immunology, especially emphasizing signaling pathways like Hippo and the role of YAP/TAZ in cancer development, stemness, and immune responses. Their work integrates advanced techniques such as single-cell and spatial transcriptomics to dissect complex biological interactions and disease mechanisms.

Best Publications

  • Role of YAP/TAZ in mechanotransduction

    Sirio Dupont;Leonardo Morsut;Mariaceleste Aragona;Elena Enzo

  • The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

    Michelangelo Cordenonsi;Francesca Zanconato;Luca Azzolin;Mattia Forcato

  • Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

    Francesca Zanconato;Mattia Forcato;Giusy Battilana;Luca Azzolin

  • YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

    Luca Azzolin;Tito Panciera;Sandra Soligo;Elena Enzo

  • Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

    Ilaria Marigo;Erika Bosio;Samantha Solito;Circe Mesa

  • Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

    Giovanna Gallina;Luigi Dolcetti;Paolo Serafini;Carmela De Santo

  • A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

    Maddalena Adorno;Michelangelo Cordenonsi;Marco Montagner;Sirio Dupont

  • A MicroRNA targeting dicer for metastasis control.

    Graziano Martello;Antonio Rosato;Francesco Ferrari;Andrea Manfrin

  • Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

    Maria T Pallotta;Ciriana Orabona;Claudia Volpi;Carmine Vacca

  • Aryl hydrocarbon receptor control of a disease tolerance defence pathway

    Alban Bessede;Alban Bessede;Marco Gargaro;Maria T. Pallotta;Davide Matino

  • IL-7 and IL-15 instruct the generation of human memory stem T cells from naïve precursors

    Nicoletta Cieri;Barbara Camisa;Fabienne Cocchiarella;Mattia Forcato

  • Regeneration of the entire human epidermis using transgenic stem cells

    Tobias Hirsch;Tobias Rothoeft;Norbert Teig;Johann W. Bauer

  • Role of TAZ as Mediator of Wnt Signaling

    Luca Azzolin;Francesca Zanconato;Silvia Bresolin;Mattia Forcato

  • Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock.

    Kenneth A. Dyar;Stefano Ciciliot;Lauren E. Wright;Rasmus S. Biensø

  • Aerobic glycolysis tunes YAP/TAZ transcriptional activity

    Elena Enzo;Giulia Santinon;Arianna Pocaterra;Mariaceleste Aragona

  • A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.

    Giada Mondanelli;Roberta Bianchi;Maria Teresa Pallotta;Ciriana Orabona

  • Comparison of computational methods for Hi-C data analysis

    Mattia Forcato;Chiara Nicoletti;Koustav Pal;Carmen Maria Livi

  • SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

    Marco Montagner;Elena Enzo;Mattia Forcato;Francesca Zanconato

  • Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma

    Marta Lionetti;Marta Biasiolo;Luca Agnelli;Katia Todoerti

  • Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.

    Francesca Zanconato;Giusy Battilana;Mattia Forcato;Letizia Filippi

Frequent Co-Authors

Antonino Neri
Antonino Neri University of Milan
Luca Agnelli
Luca Agnelli University of Milan
Giannino Del Sal
Giannino Del Sal University of Trieste
Stefano Piccolo
Stefano Piccolo University of Padua
Vincenzo Bronte
Vincenzo Bronte University of Verona
Sergio Ferrari
Sergio Ferrari University of Modena and Reggio Emilia
Ursula Grohmann
Ursula Grohmann University of Perugia
Giuseppe Basso
Giuseppe Basso University of Padua
Paolo Puccetti
Paolo Puccetti University of Perugia
Roberta Bianchi
Roberta Bianchi University of Perugia

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