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Biology and Biochemistry

D-Index
148
Citations
92996
World Ranking
195
National Ranking
134

Overview

Paul D. Robbins is affiliated with the University of Minnesota in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, contributing extensively to these areas with a focus on Molecular Biology and Physiology as subfields. Additional subjects of study include Immunology, Aging, and Cancer Research.

The scientist's work addresses numerous key topics, notably:

  • Telomeres, Telomerase, and Senescence
  • Genetics, Aging, and Longevity in Model Organisms
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • MicroRNA in Disease Regulation
  • Single-cell and Spatial Transcriptomics
  • Extracellular Vesicles in Disease
  • Circular RNAs in Diseases

Robbins has contributed papers to a range of frequent publication venues, including:

  • Aging Cell
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Aging
  • The Journals of Gerontology Series A
  • GeroScience

Frequent collaborators include Laura J. Niedernhofer, Lei Zhang, James L. Kirkland, Luise Angelini, and Tamar Tchkonia.

Significant recent publications by Robbins feature:

  • "An aged immune system drives senescence and ageing of solid organs," 2021, Nature
  • "A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues," 2022, Nature Communications
  • "Cellular senescence: a key therapeutic target in aging and diseases," 2022, Journal of Clinical Investigation
  • "Targeting cellular senescence with senotherapeutics: senolytics and senomorphics," 2022, FEBS Journal
  • "Senolytics reduce coronavirus-related mortality in old mice," 2021, Science

Best Publications

  • Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Clotilde Théry;Kenneth W. Witwer;Elena Aikawa;Maria Jose Alcaraz

  • Regulation of immune responses by extracellular vesicles

    Paul D. Robbins;Adrian E. Morelli

  • Cellular Senescence: Defining a Path Forward

    Vassilis Gorgoulis;Peter D. Adams;Andrea Alimonti;Dorothy C. Bennett

  • The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

    Yi-Yi Zhu;Tamara Tchkonia;Tamar Pirtskhalava;Adam C Gower

  • Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

    Bonnee Rubinfeld;Paul Robbins;Mona El-Gamil;Iris Albert

  • Senolytics improve physical function and increase lifespan in old age

    Ming Xu;Ming Xu;Tamar Pirtskhalava;Joshua N. Farr;Bettina M. Weigand;Bettina M. Weigand

  • Cellular senescence mediates fibrotic pulmonary disease

    Marissa J. Schafer;Thomas A. White;Koji Iijima;Andrew J. Haak

  • A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

    Srinivasa M. Srinivasula;Ramesh Hegde;Ayman Saleh;Pinaki Datta

  • Interleukin-17 promotes angiogenesis and tumor growth.

    Muneo Numasaki;Jun Ichi Fukushi;Mayumi Ono;Satwant K. Narula

  • Negative regulation of the Apaf-1 apoptosome by Hsp70.

    Ayman Saleh;Srinivasa M. Srinivasula;Levent Balkir;Paul D. Robbins

  • Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.

    Yi Zhu;Tamara Tchkonia;Heike Fuhrmann-Stroissnigg;Haiming M. Dai

  • Clonal Isolation of Muscle-Derived Cells Capable of Enhancing Muscle Regeneration and Bone Healing

    Joon Yung Lee;Zhuqing Qu-Petersen;Baohong Cao;Shigemi Kimura

  • Identification of essential genes for cancer immunotherapy

    Shashank J. Patel;Neville E. Sanjana;Rigel J. Kishton;Arash Eidizadeh

  • Viral Vectors for Gene Therapy

    Paul D. Robbins;Steven C. Ghivizzani

  • Fisetin is a senotherapeutic that extends health and lifespan

    Matthew J. Yousefzadeh;Yi Zhu;Sara J. McGowan;Luise Angelini

  • Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

    Stephanie Lefèvre;Anette Knedla;Christoph Tennie;Andreas Kampmann

  • Development of Approaches to Improve Cell Survival in Myoblast Transfer Therapy

    Zhuqing Qu;Levent Balkir;Judith C.T. van Deutekom;Paul D. Robbins

  • An aged immune system drives senescence and ageing of solid organs.

    Matthew J. Yousefzadeh;Rafael R. Flores;Yi Zhu;Zoe C. Schmiechen

  • Identification of HSP90 inhibitors as a novel class of senolytics

    Heike Fuhrmann-Stroissnigg;Yuan Yuan Ling;Jing Zhao;Sara J. McGowan

  • New agents that target senescent cells: the flavone, fisetin, and the BCL-X L inhibitors, A1331852 and A1155463.

    Yi Zhu;Ewald J. Doornebal;Tamar Pirtskhalava;Nino Giorgadze

Frequent Co-Authors

Laura J. Niedernhofer
Laura J. Niedernhofer University of Minnesota
Andrea Gambotto
Andrea Gambotto University of Pittsburgh
Michael T. Lotze
Michael T. Lotze University of Pittsburgh
Hideaki Tahara
Hideaki Tahara University of Tokyo
Steven C. Ghivizzani
Steven C. Ghivizzani University of Florida
Simon C. Watkins
Simon C. Watkins University of Pittsburgh
Johnny Huard
Johnny Huard The University of Texas Health Science Center at Houston
Joseph C. Glorioso
Joseph C. Glorioso University of Pittsburgh
Walter J. Storkus
Walter J. Storkus University of Pittsburgh

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