João F. Passos

Overview

Best Publications

• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

  Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  10661
  Citations

• Cellular Senescence: Defining a Path Forward

  Vassilis Gorgoulis;Peter D. Adams;Andrea Alimonti;Dorothy C. Bennett

  2153
  Citations

• Cellular senescence mediates fibrotic pulmonary disease

  Marissa J. Schafer;Thomas A. White;Koji Iijima;Andrew J. Haak

  1535
  Citations

• Feedback between p21 and reactive oxygen production is necessary for cell senescence

  João F Passos;Glyn Nelson;Chunfang Wang;Torsten Richter

  994
  Citations

• Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

  La Tonya J. Hickson;Larissa G.P. Langhi Prata;Shane A. Bobart;Tamara K. Evans

  897
  Citations

• Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

  Graeme Hewitt;Diana Jurk;Francisco D.M. Marques;Clara Correia-Melo

  878
  Citations

• Cellular senescence drives age-dependent hepatic steatosis.

  Mikolaj Ogrodnik;Satomi Miwa;Tamar Tchkonia;Dina Tiniakos;Dina Tiniakos

  829
  Citations

• Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

  Diana Jurk;Caroline Wilson;Joao F. Passos;Fiona Oakley

  822
  Citations

• Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.

  João F Passos;Gabriele Saretzki;Gabriele Saretzki;Shaheda Ahmed;Shaheda Ahmed;Glyn Nelson

  787
  Citations

• Mitochondria are required for pro‐ageing features of the senescent phenotype

  Clara Correia-Melo;Clara Correia-Melo;Francisco D.M. Marques;Rhys Anderson;Graeme Hewitt

  660
  Citations

• Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress.

  Shaheda Ahmed;João F. Passos;Matthew J. Birket;Tina Beckmann

  543
  Citations

• Lysosome-mediated processing of chromatin in senescence

  Andre Ivanov;Jeff Pawlikowski;Indrani Manoharan;John van Tuyn

  516
  Citations

• Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

  Branca I. Pereira;Oliver P. Devine;Milica Vukmanovic-Stejic;Emma S. Chambers

  503
  Citations

• Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

  Mikolaj Ogrodnik;Mikolaj Ogrodnik;Yi Zhu;Larissa G.P. Langhi;Tamar Tchkonia

  419
  Citations

• Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

  Joel S. Riley;Giovanni Quarato;Catherine Cloix;Jonathan Lopez

  405
  Citations

• Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

  Rhys Anderson;Anthony Lagnado;Damien Maggiorani;Anna Walaszczyk

  401
  Citations

• DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

  João F. Passos;Gabriele Saretzki;Thomas von Zglinicki

  392
  Citations

• Telomeres and Cell Senescence - Size Matters Not

  Stella Victorelli;João F. Passos

  336
  Citations

• Stress, cell senescence and organismal ageing.

  João Pedro de Magalhães;João F. Passos

  314
  Citations

• Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.

  Gabriele Saretzki;Gabriele Saretzki;Theresia Walter;Stuart Atkinson;Jõao F. Passos

  301
  Citations