Laura J. Niedernhofer spends much of her time researching DNA repair, Nucleotide excision repair, DNA damage, Cancer research and Progeria. Her DNA repair study frequently draws connections between adjacent fields such as Cell aging. Her study in Nucleotide excision repair is interdisciplinary in nature, drawing from both Molecular biology, Genome instability and Homologous recombination.
Her research integrates issues of Cell biology and Longevity in her study of DNA damage. Her Cancer research research incorporates themes from Apoptosis and Senolytic. Her Progeria study combines topics in areas such as Endocrinology, Senescence, Internal medicine, Ageing and Progeroid syndromes.
The scientist’s investigation covers issues in DNA repair, DNA damage, Cell biology, Senescence and Nucleotide excision repair. Her DNA repair research is multidisciplinary, relying on both Molecular biology, Cancer research, Progeria and Genome instability. Her research in DNA damage intersects with topics in Oxidative stress, Internal medicine and NF-κB.
In her study, Pathology, Tobacco smoke, Matrix metalloproteinase and Homeostasis is strongly linked to Intervertebral disc, which falls under the umbrella field of Cell biology. Her work in Senescence addresses subjects such as Senolytic, which are connected to disciplines such as Apoptosis. Her work deals with themes such as Xeroderma pigmentosum, Homologous recombination and Bioinformatics, which intersect with Nucleotide excision repair.
Laura J. Niedernhofer mostly deals with Senescence, Cell biology, DNA damage, Progeria and Phenotype. Her Senescence study incorporates themes from Cell, Senolytic, Stem cell and Bioinformatics. Her Cell biology research is multidisciplinary, incorporating perspectives in Oxidative stress, Adult stem cell, Transcription factor, Programmed cell death and In vivo.
Her DNA damage study combines topics from a wide range of disciplines, such as NF-κB, Signal transduction, Endogeny, DNA repair and Kinase. Laura J. Niedernhofer is interested in Genotoxic Stress, which is a field of DNA repair. Her Progeria research includes elements of Lamin, Cell growth, Progenitor cell, Progerin and Nuclear lamina.
Senescence, Cell biology, DNA damage, Health span and Phenotype are her primary areas of study. Her biological study spans a wide range of topics, including Senolytic, Model organism, mTORC1, Tissue homeostasis and Signal transduction. Her Senolytic research is multidisciplinary, incorporating elements of Cell, Clinical trial, Bioinformatics, Senescent cell and Disease.
Her studies deal with areas such as Oxidative stress, Progeria, Apoptosis and Adult stem cell as well as Cell biology. The concepts of her Progeria study are interwoven with issues in Lamin, Cell growth, DNA repair, Genotoxic Stress and Messenger RNA. Laura J. Niedernhofer has researched DNA damage in several fields, including Transcription factor, NF-κB, Stem cell, Mediator and Kinase.
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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu;Tamara Tchkonia;Tamar Pirtskhalava;Adam C Gower.
Aging Cell (2015)
Senolytics improve physical function and increase lifespan in old age
Ming Xu;Ming Xu;Tamar Pirtskhalava;Joshua N. Farr;Bettina M. Weigand;Bettina M. Weigand.
Nature Medicine (2018)
Cellular Senescence: Defining a Path Forward
Vassilis Gorgoulis;Peter D. Adams;Andrea Alimonti;Dorothy C. Bennett.
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Laura J. Niedernhofer;George A. Garinis;Anja Raams;Astrid S. Lalai.
The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks
Laura J. Niedernhofer;Hanny Odijk;Magda Budzowska;Ellen van Drunen.
Molecular and Cellular Biology (2004)
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.
Yi Zhu;Tamara Tchkonia;Heike Fuhrmann-Stroissnigg;Haiming M. Dai.
Aging Cell (2016)
Malondialdehyde, a Product of Lipid Peroxidation, Is Mutagenic in Human Cells
Laura J. Niedernhofer;J. Scott Daniels;Carol A. Rouzer;Rachel E. Greene.
Journal of Biological Chemistry (2003)
ERCC1/XPF Removes the 3′ Overhang from Uncapped Telomeres and Represses Formation of Telomeric DNA-Containing Double Minute Chromosomes
Xu-Dong Zhu;Laura Niedernhofer;Bernhard Kuster;Matthias Mann.
Molecular Cell (2003)
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
Jeremy S. Tilstra;Andria R. Robinson;Jin Wang;Siobhán Q. Gregg.
Journal of Clinical Investigation (2012)
Identification of HSP90 inhibitors as a novel class of senolytics
Heike Fuhrmann-Stroissnigg;Yuan Yuan Ling;Jing Zhao;Sara J. McGowan.
Nature Communications (2017)
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