World's Best Scientists 2026 revealed!
Laura J. Niedernhofer

Laura J. Niedernhofer

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
33046
World Ranking
3632
National Ranking
1812

Overview

Laura J. Niedernhofer is affiliated with the University of Minnesota in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a focus on subfields including Physiology, Molecular Biology, Immunology, Aging, and Cancer Research.

The scientist's research topics encompass a range of areas related to cellular and molecular processes, particularly those involved in aging and longevity. Key topics include:

  • Telomeres, Telomerase, and Senescence
  • Genetics, Aging, and Longevity in Model Organisms
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Single-cell and Spatial Transcriptomics
  • DNA Repair Mechanisms
  • Cytomegalovirus and Herpesvirus Research
  • Extracellular Vesicles in Disease

Laura J. Niedernhofer has contributed to multiple publications, frequently publishing in the following venues:

  • Aging Cell
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Aging
  • Aging
  • Innovation in Aging

Their notable recent papers include:

  • "An aged immune system drives senescence and ageing of solid organs" (2021, Nature)
  • "A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues" (2022, Nature Communications)
  • "Cellular senescence: a key therapeutic target in aging and diseases" (2022, Journal of Clinical Investigation)
  • "Targeting cellular senescence with senotherapeutics: senolytics and senomorphics" (2022, FEBS Journal)
  • "Senolytics reduce coronavirus-related mortality in old mice" (2021, Science)

Collaboration is an important aspect of their scientific work, with frequent co-authors including:

  • Paul D. Robbins
  • Matthew J. Yousefzadeh
  • James L. Kirkland
  • Luise Angelini
  • Tamar Tchkonia

Best Publications

  • Cellular Senescence: Defining a Path Forward

    Vassilis Gorgoulis;Peter D. Adams;Andrea Alimonti;Dorothy C. Bennett

  • The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

    Yi-Yi Zhu;Tamara Tchkonia;Tamar Pirtskhalava;Adam C Gower

  • Senolytics improve physical function and increase lifespan in old age

    Ming Xu;Ming Xu;Tamar Pirtskhalava;Joshua N. Farr;Bettina M. Weigand;Bettina M. Weigand

  • Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.

    Yi Zhu;Tamara Tchkonia;Heike Fuhrmann-Stroissnigg;Haiming M. Dai

  • A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

    Laura J. Niedernhofer;George A. Garinis;Anja Raams;Astrid S. Lalai

  • Malondialdehyde, a Product of Lipid Peroxidation, Is Mutagenic in Human Cells

    Laura J. Niedernhofer;J. Scott Daniels;Carol A. Rouzer;Rachel E. Greene

  • Fisetin is a senotherapeutic that extends health and lifespan

    Matthew J. Yousefzadeh;Yi Zhu;Sara J. McGowan;Luise Angelini

  • The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks

    Laura J. Niedernhofer;Hanny Odijk;Magda Budzowska;Ellen van Drunen

  • An aged immune system drives senescence and ageing of solid organs.

    Matthew J. Yousefzadeh;Rafael R. Flores;Yi Zhu;Zoe C. Schmiechen

  • Identification of HSP90 inhibitors as a novel class of senolytics

    Heike Fuhrmann-Stroissnigg;Yuan Yuan Ling;Jing Zhao;Sara J. McGowan

  • New agents that target senescent cells: the flavone, fisetin, and the BCL-X L inhibitors, A1331852 and A1155463.

    Yi Zhu;Ewald J. Doornebal;Tamar Pirtskhalava;Nino Giorgadze

  • ERCC1/XPF Removes the 3′ Overhang from Uncapped Telomeres and Represses Formation of Telomeric DNA-Containing Double Minute Chromosomes

    Xu Dong Zhu;Laura Niedernhofer;Bernhard Kuster;Matthias Mann

  • The Clinical Potential of Senolytic Drugs

    James L. Kirkland;Tamara Tchkonia;Yi Zhu;Laura J. Niedernhofer

  • NF-κB inhibition delays DNA damage–induced senescence and aging in mice

    Jeremy S. Tilstra;Andria R. Robinson;Jin Wang;Siobhán Q. Gregg

  • ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

    Anwaar Ahmad;Andria Rasile Robinson;Anette Duensing;Ellen van Drunen

  • Fanconi anemia (cross)linked to DNA repair.

    Laura J. Niedernhofer;Astrid S. Lalai;Jan H.J. Hoeijmakers

  • NF-κB in Aging and Disease

    Jeremy S. Tilstra;Cheryl L. Clauson;Laura J. Niedernhofer;Paul D. Robbins

  • Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA

    Lijuan Fu;Candace R. Guerrero;Na Zhong;Nicholas J. Amato

  • Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair

    Cheryl Clauson;Orlando D. Schärer;Laura Niedernhofer

  • Impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with cockayne syndrome

    Ingrid van der Pluijm;George A Garinis;Renata M. C Brandt;Theo G. M. F Gorgels;Theo G. M. F Gorgels

Frequent Co-Authors

Paul D. Robbins
Paul D. Robbins University of Minnesota
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Johnny Huard
Johnny Huard The University of Texas Health Science Center at Houston
Wim Vermeulen
Wim Vermeulen Erasmus University Rotterdam
Yinsheng Wang
Yinsheng Wang University of California, Riverside
Roland Kanaar
Roland Kanaar Erasmus University Rotterdam
Judith Campisi
Judith Campisi Buck Institute for Research on Aging
Nicolaas G. J. Jaspers
Nicolaas G. J. Jaspers Erasmus University Rotterdam
Jan Vijg
Jan Vijg Albert Einstein College of Medicine

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry in the USA opens doors to a diverse range of healthcare career pathways. Many students expand their opportunities by pursuing specialized online programs aligned with growing fields.

Diagnostic imaging, for example, is an in-demand area. Prospective technologists can start with online sonography certificate programs or consider further training through rad tech online programs, both providing flexibility and industry-relevant coursework.

If you’re interested in health and nutrition, the top dietetics programs in the us offer graduate-level study online at prestigious institutions—helpful for those wishing to become registered dietitians and nutritionists.

For those seeking quicker entry into the workforce, online medical assistant programs that accept financial aid provide career-focused training with valuable financial support options.

Exploring these online degrees broadens your understanding of healthcare roles, helping you find a track that matches your interests in Biology, Biochemistry, and beyond.

Best Scientists Citing Laura J. Niedernhofer

Trending Scientists

Recently Published Articles