Adipose tissue, Senolytic, Internal medicine, Endocrinology and Senescence are his primary areas of study. His biological study spans a wide range of topics, including Inflammation, Proinflammatory cytokine, Cell aging and Longevity. The various areas that James L. Kirkland examines in his Senolytic study include Apoptosis, Navitoclax, Cancer research and Immunology.
His primary area of study in Internal medicine is in the field of Disease. James L. Kirkland combines subjects such as Progenitor cell, Gene expression and Cellular differentiation with his study of Endocrinology. His Senescence research incorporates themes from Signal transduction and Ageing.
His main research concerns Internal medicine, Endocrinology, Adipose tissue, Senescence and Senolytic. His Internal medicine research includes themes of Diabetes mellitus and Gene expression. His work carried out in the field of Endocrinology brings together such families of science as Proinflammatory cytokine and Cellular differentiation.
His work in Adipose tissue addresses subjects such as Inflammation, which are connected to disciplines such as Immune system and Signal transduction. Many of his research projects under Senescence are closely connected to Mechanism with Mechanism, tying the diverse disciplines of science together. His work deals with themes such as Navitoclax, Cancer research and Clinical trial, Bioinformatics, which intersect with Senolytic.
His primary scientific interests are in Senolytic, Senescence, Internal medicine, Endocrinology and Cancer research. He has researched Senolytic in several fields, including Clinical trial, Bioinformatics, Inflammation, Disease and Fibrosis. His Senescence study integrates concerns from other disciplines, such as Phenotype, Andrology, Adipose tissue and Telomere.
His Adipose tissue research includes elements of Biomarker and Renal fibrosis. James L. Kirkland interconnects Diabetes mellitus and Gastroenterology in the investigation of issues within Internal medicine. His Endocrinology research is multidisciplinary, relying on both PI3K/AKT/mTOR pathway and Stem cell.
James L. Kirkland mainly investigates Senolytic, Senescence, Internal medicine, Phenotype and Adipose tissue. The study incorporates disciplines such as Cancer research, Clinical trial, Bioinformatics and Disease in addition to Senolytic. His work carried out in the field of Senescence brings together such families of science as Immunology, Hyperoxia and Osteoporosis.
His Internal medicine research integrates issues from Ex vivo and Endocrinology. James L. Kirkland interconnects Cell biology and Ageing in the investigation of issues within Phenotype. His study in Adipose tissue is interdisciplinary in nature, drawing from both Inflammation, Soft tissue, Asymptomatic and Diabetes mellitus.
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Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders
Darren J. Baker;Tobias Wijshake;Tamar Tchkonia;Nathan K. LeBrasseur.
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.
Tamara Tchkonia;Yi Zhu;Jan van Deursen;Judith Campisi.
Journal of Clinical Investigation (2013)
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu;Tamara Tchkonia;Tamar Pirtskhalava;Adam C Gower.
Aging Cell (2015)
Fat tissue, aging, and cellular senescence
Tamara Tchkonia;Dean E. Morbeck;Thomas Von Zglinicki;Jan Van Deursen.
Aging Cell (2010)
Senolytics improve physical function and increase lifespan in old age
Ming Xu;Ming Xu;Tamar Pirtskhalava;Joshua N. Farr;Bettina M. Weigand;Bettina M. Weigand.
Nature Medicine (2018)
Cellular senescence mediates fibrotic pulmonary disease
Marissa J. Schafer;Thomas A. White;Koji Iijima;Andrew J. Haak.
Nature Communications (2017)
Senescence and apoptosis: dueling or complementary cell fates?
Bennett G Childs;Darren J Baker;James L Kirkland;Judith Campisi.
EMBO Reports (2014)
Cellular Senescence: A Translational Perspective.
James L. Kirkland;Tamara Tchkonia.
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
Tim J. Schulz;Tian Lian Huang;Thien T. Tran;Hongbin Zhang.
Proceedings of the National Academy of Sciences of the United States of America (2011)
Mechanisms and Metabolic Implications of Regional Differences among Fat Depots
Tamara Tchkonia;Thomas Thomou;Yi Zhu;Iordanes Karagiannides.
Cell Metabolism (2013)
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