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James L. Kirkland

James L. Kirkland

D-Index & Metrics

Medicine

D-Index
117
Citations
62875
World Ranking
4145
National Ranking
2271

Overview

James L. Kirkland is affiliated with the Mayo Clinic in the United States. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology. The main subfields of study include physiology, molecular biology, immunology, aging, and genetics.

The scientist's work covers several key topics, such as:

  • Telomeres, Telomerase, and Senescence
  • Genetics, Aging, and Longevity in Model Organisms
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Single-cell and Spatial Transcriptomics
  • Adipokines, Inflammation, and Metabolic Diseases
  • Circadian Rhythm and Melatonin
  • Skin Protection and Aging

James L. Kirkland has published extensively in various scientific venues. Frequent publication sites include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Aging Cell
  • Aging
  • GeroScience
  • Nature Communications

Some of the notable recent publications featuring their work are:

  • "Senolytic drugs: from discovery to translation," 2020, Journal of Internal Medicine
  • "Cellular senescence: the good, the bad and the unknown," 2022, Nature Reviews Nephrology
  • "Cellular senescence and senolytics: the path to the clinic," 2022, Nature Medicine
  • "A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues," 2022, Nature Communications
  • "The role of cellular senescence in ageing and endocrine disease," 2020, Nature Reviews Endocrinology

The scientist frequently collaborates with other researchers. Some frequent co-authors include Tamar Tchkonia, Sundeep Khosla, Laura J. Niedernhofer, Nathan K. LeBrasseur, and Paul D. Robbins.

Best Publications

  • Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders

    Darren J. Baker;Tobias Wijshake;Tamar Tchkonia;Nathan K. LeBrasseur

  • The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

    Yi-Yi Zhu;Tamara Tchkonia;Tamar Pirtskhalava;Adam C Gower

  • Senolytics improve physical function and increase lifespan in old age

    Ming Xu;Ming Xu;Tamar Pirtskhalava;Joshua N. Farr;Bettina M. Weigand;Bettina M. Weigand

  • Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.

    Tamara Tchkonia;Yi Zhu;Jan van Deursen;Judith Campisi

  • Cellular senescence mediates fibrotic pulmonary disease

    Marissa J. Schafer;Thomas A. White;Koji Iijima;Andrew J. Haak

  • Sarcopenia: Aging-Related Loss of Muscle Mass and Function.

    Lars Larsson;Hans Degens;Meishan Li;Leonardo Salviati

  • Fat tissue, aging, and cellular senescence

    Tamara Tchkonia;Dean E. Morbeck;Thomas Von Zglinicki;Jan Van Deursen

  • Cellular Senescence: A Translational Perspective.

    James L. Kirkland;Tamara Tchkonia

  • Targeting cellular senescence prevents age-related bone loss in mice

    Joshua N Farr;Ming Xu;Megan M Weivoda;David G Monroe

  • Senescence and apoptosis: dueling or complementary cell fates?

    Bennett G Childs;Darren J Baker;James L Kirkland;Judith Campisi

  • Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.

    Yi Zhu;Tamara Tchkonia;Heike Fuhrmann-Stroissnigg;Haiming M. Dai

  • Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

    La Tonya J. Hickson;Larissa G.P. Langhi Prata;Shane A. Bobart;Tamara K. Evans

  • Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.

    Jamie N. Justice;Anoop M. Nambiar;Tamar Tchkonia;Nathan K. LeBrasseur

  • Cellular senescence drives age-dependent hepatic steatosis.

    Mikolaj Ogrodnik;Satomi Miwa;Tamar Tchkonia;Dina Tiniakos;Dina Tiniakos

  • Senolytic drugs: from discovery to translation.

    James L. Kirkland;Tamar Tchkonia

  • Fisetin is a senotherapeutic that extends health and lifespan

    Matthew J. Yousefzadeh;Yi Zhu;Sara J. McGowan;Luise Angelini

  • Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

    Tamara Tchkonia;Thomas Thomou;Yi Zhu;Iordanes Karagiannides

  • JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

    Ming Xu;Tamara Tchkonia;Husheng Ding;Mikolaj Ogrodnik;Mikolaj Ogrodnik

  • Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

    Carolyn M. Roos;Bin Zhang;Allyson K. Palmer;Mikolaj B. Ogrodnik;Mikolaj B. Ogrodnik

  • Identification of HSP90 inhibitors as a novel class of senolytics

    Heike Fuhrmann-Stroissnigg;Yuan Yuan Ling;Jing Zhao;Sara J. McGowan

Frequent Co-Authors

Tamar Tchkonia
Tamar Tchkonia Cedars-Sinai Medical Center
Sundeep Khosla
Sundeep Khosla Mayo Clinic
Laura J. Niedernhofer
Laura J. Niedernhofer University of Minnesota
João F. Passos
João F. Passos Mayo Clinic
Thomas A. White
Thomas A. White Mayo Clinic
Paul D. Robbins
Paul D. Robbins University of Minnesota
Barbara E. Corkey
Barbara E. Corkey Boston University
Judith Campisi
Judith Campisi Buck Institute for Research on Aging

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