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Jan M. van Deursen

Jan M. van Deursen

D-Index & Metrics

Biology and Biochemistry

D-Index
105
Citations
55189
World Ranking
1175
National Ranking
696

Overview

Jan M. van Deursen is affiliated with the Mayo Clinic in the United States. Their research primarily spans biochemistry, genetics, and molecular biology, with additional focus on medicine. Within these broad fields, their work addresses subfields such as molecular biology, physiology, cell biology, genetics, and endocrinology, diabetes, and metabolism.

The scientist's research covers several important topics including:

  • Growth Hormone and Insulin-like Growth Factors
  • Alzheimer's disease research and treatments
  • Prion Diseases and Protein Misfolding
  • Cellular transport and secretion
  • Telomeres, Telomerase, and Senescence
  • DNA Repair Mechanisms
  • Frailty in Older Adults

Van Deursen has published numerous papers with several recurring publication venues. Notable venues include the JNCI Journal of the National Cancer Institute, bioRxiv (Cold Spring Harbor Laboratory), the Journal of the Endocrine Society, Genes & Development, and Life Science Alliance.

Their recent papers include:

  • Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy (2021, JNCI Journal of the National Cancer Institute)
  • Strategies to Prevent or Remediate Cancer and Treatment-Related Aging (2020, JNCI Journal of the National Cancer Institute)
  • Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis (2021, Genes & Development)
  • Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain (2023, Life Science Alliance)
  • Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity (2025, Frontiers in Endocrinology)

Frequent coauthors working alongside van Deursen include Alain de Bruin, Mirjam H. Koster, Bart van de Sluis, Krishma Tailor, and Janine van Ree, reflecting ongoing collaborations in their research endeavors.

Best Publications

  • Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders

    Darren J. Baker;Tobias Wijshake;Tamar Tchkonia;Nathan K. LeBrasseur

  • Naturally occurring p16 Ink4a -positive cells shorten healthy lifespan

    Darren J. Baker;Bennett G. Childs;Matej Durik;Melinde E. Wijers

  • The role of senescent cells in ageing

    Jan M. van Deursen

  • AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

    Tsukasa Okuda;Jan van Deursen;Scott W Hiebert;Gerard Grosveld

  • Cellular senescence in aging and age-related disease: from mechanisms to therapy

    Bennett G Childs;Matej Durik;Darren J Baker;Jan M van Deursen

  • Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.

    Tamara Tchkonia;Yi Zhu;Jan van Deursen;Judith Campisi

  • Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

    Stephan Teglund;Catriona McKay;Erin Schuetz;Jan M van Deursen

  • Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

    Evan Parganas;Demin Wang;Dimitrios Stravopodis;David J. Topham

  • Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

    Ok Hee Jeon;Chaekyu Kim;Chaekyu Kim;Remi Martin Laberge;Marco Demaria;Marco Demaria

  • Fat tissue, aging, and cellular senescence

    Tamara Tchkonia;Dean E. Morbeck;Thomas Von Zglinicki;Jan Van Deursen

  • Senescent cells: an emerging target for diseases of ageing.

    Bennett G. Childs;Martina Gluscevic;Darren J. Baker;Remi Martin Laberge

  • Senescent intimal foam cells are deleterious at all stages of atherosclerosis

    Bennett G. Childs;Darren J. Baker;Tobias Wijshake;Tobias Wijshake;Cheryl A. Conover

  • Senescence and apoptosis: dueling or complementary cell fates?

    Bennett G Childs;Darren J Baker;James L Kirkland;Judith Campisi

  • Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

    Tyler J. Bussian;Asef Aziz;Charlton F. Meyer;Barbara L. Swenson

  • BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

    Darren J. Baker;Karthik B. Jeganathan;J. Douglas Cameron;Michael Thompson

  • MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

    Zhenkun Lou;Katherine Minter-Dykhouse;Sonia Franco;Monica Gostissa

  • Defective Lymphoid Development in Mice Lacking Jak3

    Tetsuya Nosaka;Jan M. A. van Deursen;Ralph A. Tripp;William E. Thierfelder

  • Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

    Richard Moriggl;David J Topham;Stephan Teglund;Veronika Sexl

  • Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

    Haojie Huang;Kevin M. Regan;Fang Wang;Diping Wang

  • Regulation of the T-Independent Humoral Response by TACI

    Götz Ulrich Von Bülow;Jan M. Van Deursen;Richard J. Bram

Frequent Co-Authors

Tamar Tchkonia
Tamar Tchkonia Cedars-Sinai Medical Center
Marco Demaria
Marco Demaria University Medical Center Groningen
Judith Campisi
Judith Campisi Buck Institute for Research on Aging
Hu Li
Hu Li Mayo Clinic
Alain de Bruin
Alain de Bruin Utrecht University
Gerard Grosveld
Gerard Grosveld St. Jude Children's Research Hospital
Junjie Chen
Junjie Chen The University of Texas MD Anderson Cancer Center
James N. Ihle
James N. Ihle St. Jude Children's Research Hospital
Jennifer H. Elisseeff
Jennifer H. Elisseeff Johns Hopkins University

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