World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
13326
World Ranking
15992
National Ranking
389

Overview

Alain de Bruin is affiliated with Utrecht University in the Netherlands and conducts research primarily within the fields of Biochemistry, Genetics, and Molecular Biology as well as Medicine. Their work spans a wide range of subfields including Molecular Biology, Oncology, Genetics, Epidemiology, and Immunology.

The main research topics addressed by de Bruin include:

  • Liver Disease Diagnosis and Treatment
  • Cancer-related Molecular Pathways
  • DNA Repair Mechanisms
  • Drug Transport and Resistance Mechanisms
  • Cholesterol and Lipid Metabolism
  • Microtubule and Mitosis Dynamics
  • Epigenetics and DNA Methylation

Frequent co-authors in de Bruin's research include Laura Bongiovanni, Mirjam H. Koster, Bart Westendorp, Niels Kloosterhuis, and Bart van de Sluis.

De Bruin has published extensively in several scientific venues with multiple papers appearing in bioRxiv (Cold Spring Harbor Laboratory), Hepatology, Journal of Hepatology, Cell Reports, and Oncogene.

Representative recent papers include:

  • "Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in HepatocytesSummary" (2021), published in DOAJ (DOAJ: Directory of Open Access Journals)
  • "The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis" (2021), published in Molecular Metabolism
  • "E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration" (2020), published in Developmental Cell
  • "T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice" (2022), published in Nature Communications
  • "OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis" (2020), published in Cell Reports

Best Publications

  • An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

    Marco Demaria;Naoko Ohtani;Sameh A Youssef;Francis Rodier

  • Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

    Marco Demaria;Marco Demaria;Monique N. O'Leary;Jianhui Chang;Lijian Shao

  • Direct evidence for Epithelial-Mesenchymal transitions in breast cancer

    Anthony J. Trimboli;Koichi Fukino;Alain de Bruin;Guo Wei

  • Extra-embryonic function of Rb is essential for embryonic development and viability.

    Lizhao Wu;Alain de Bruin;Harold I. Saavedra;Maja Starovic

  • MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling

    Paula A. Da Costa Martins;Kanita Salic;Monika M. Gladka;Anne Sophie Armand

  • A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis.

    Eelke Brandsma;Niels J. Kloosterhuis;Mirjam Koster;Mirjam Koster;Daphne C. Dekker

  • Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation.

    Alain de Bruin;Baidehi Maiti;Laszlo Jakoi;Cynthia Timmers

  • High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

    Roel A. van der Heijden;Fareeba Sheedfar;Martine C. Morrison;Pascal P. H. Hommelberg

  • In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(ε-caprolactone).

    Hajar Seyednejad;Debby Gawlitta;Raoul V. Kuiper;Alain de Bruin

  • Synergistic Function of E2F7 and E2F8 Is Essential for Cell Survival and Embryonic Development

    Jing Li;Jing Li;Cong Ran;Cong Ran;Edward Li;Edward Li;Faye Gordon;Faye Gordon

  • Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation.

    Baidehi Maiti;Jing Li;Alain de Bruin;Faye Gordon

  • A Central Role for the Armadillo Protein Plakoglobin in the Autoimmune Disease Pemphigus Vulgaris

    Reto Caldelari;Alain de Bruin;Dominique Baumann;Maja M. Suter

  • Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin.

    Lina Williamson;Natalia A Raess;Reto Caldelari;Anthony Zakher

  • Physiological significance of polyploidization in mammalian cells

    Shusil K. Pandit;Bart Westendorp;Alain de Bruin

  • E2F8 is essential for polyploidization in mammalian cells

    Shusil K. Pandit;Bart Westendorp;Sathidpak Nantasanti;Elsbeth van Liere

  • Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice

    Alain de Bruin;Lizhao Wu;Harold I. Saavedra;Pamela Wilson

  • Essential Role for Survivin in Early Brain Development

    Yuying Jiang;Alain de Bruin;Hugo Caldas;Jason Fangusaro;Jason Fangusaro

  • E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.

    Bart G M W Weijts;Walbert J Bakker;Peter W A Cornelissen;Kuo-Hsuan Liang

  • The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism

    Rami I. Aqeilan;Mohammad Q. Hassan;Alain De Bruin;John P. Hagan

  • Full ablation of C9orf72 in mice causes immune system-related pathology and neoplastic events but no motor neuron defects

    Emma Sudria-Lopez;Max Koppers;Marina de Wit;Christiaan van der Meer

Frequent Co-Authors

Gustavo Leone
Gustavo Leone Medical University of South Carolina
Marten H. Hofker
Marten H. Hofker University Medical Center Groningen
Folkert Kuipers
Folkert Kuipers University Medical Center Groningen
Edwin Cuppen
Edwin Cuppen Utrecht University
Stefan Schulte-Merker
Stefan Schulte-Merker University of Münster
Christian Trautwein
Christian Trautwein RWTH Aachen University
Andreas Villunger
Andreas Villunger Innsbruck Medical University
Judith Campisi
Judith Campisi Buck Institute for Research on Aging
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry opens doors to a wide range of healthcare and science careers. For those looking to advance quickly in specialized nursing fields, options like the 1 year pmhnp program are designed for fast, focused progression in psychiatric-mental health nursing. Likewise, the fastest post master's fnp certificate offers a streamlined route for nurses wanting to become family nurse practitioners with minimal disruption to their careers.

If nutrition science is more your path, consider an online nutrition degree—an affordable way to qualify for roles in dietetics, wellness, and allied health. For registered nurses seeking professional advancement, an rn to bsn online no clinicals program offers a flexible, streamlined curriculum with no required on-site clinicals.

These online opportunities make it possible to specialize or upskill quickly, supporting career changes or promotions within biology- and biochemistry-related fields—no matter where you are in your professional journey.

Best Scientists Citing Alain de Bruin

Trending Scientists

Recently Published Articles