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Biology and Biochemistry

D-Index
79
Citations
22964
World Ranking
4302
National Ranking
2099

Overview

Gustavo Leone is affiliated with the Medical University of South Carolina in the United States. Their research primarily falls within the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on oncology and molecular biology.

Their recent publications include several notable papers illustrating a focus on cancer biology and cellular molecular mechanisms. Key papers include:

  • The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis, 2023, Nature Communications
  • Cyclin D-CDK4/6 functions in cancer, 2020, Advances in Cancer Research
  • RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site, 2021, Cell Reports
  • Stromal Platelet-Derived Growth Factor Receptor-β Signaling Promotes Breast Cancer Metastasis in the Brain, 2020, Cancer Research
  • Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia, 2021, Journal of Clinical Investigation

Frequent co-authors working with Gustavo Leone include:

  • Michael C. Ostrowski
  • Melodie Parrish
  • Xue-Zhong Yu
  • Yongxia Wu
  • Victor X. Jin

The scientist's work is often published in the following venues:

  • Cancer Research
  • Advances in Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cell Reports

Their research emphasis explores several subfields including:

  • Oncology
  • Molecular Biology
  • Cancer Research
  • Pulmonary and Respiratory Medicine
  • Surgery

The main topics covered by Gustavo Leone's research address:

  • Pancreatic and Hepatic Oncology Research
  • Cancer Cells and Metastasis
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Cancer-related Molecular Pathways
  • Social Media in Health Education
  • Health Literacy and Information Accessibility

Best Publications

  • Emerging roles of E2Fs in cancer: an exit from cell cycle control

    Hui-Zi Chen;Shih-Yin Tsai;Gustavo Leone

  • Distinct roles for E2F proteins in cell growth control and apoptosis

    James DeGregori;Gustavo Leone;Alexander Miron;Laszlo Jakoi

  • The E2F1–3 transcription factors are essential for cellular proliferation

    Lizhao Wu;Cynthia Timmers;Baidehi Maiti;Harold I. Saavedra

  • Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

    Seiichi Ishida;Erich Huang;Harry Zuzan;Rainer Spang

  • The broken cycle: E2F dysfunction in cancer.

    Lindsey N Kent;Gustavo Leone

  • Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

    Gustavo Leone;James DeGregori;Rosalie Sears;Laszlo Jakoi

  • Pten in stromal fibroblasts suppresses mammary epithelial tumours

    Anthony J. Trimboli;Carmen Z. Cantemir-Stone;Fu Li;Julie A. Wallace

  • Ras Enhances Myc Protein Stability

    Rosalie Sears;Gustavo Leone;James DeGregori;Joseph R Nevins

  • Direct evidence for Epithelial-Mesenchymal transitions in breast cancer

    Anthony J. Trimboli;Koichi Fukino;Alain de Bruin;Guo Wei

  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

    Gustavo Leone;James DeGregori;Zhen Yan;Laszlo Jakoi

  • Extra-embryonic function of Rb is essential for embryonic development and viability.

    Lizhao Wu;Alain de Bruin;Harold I. Saavedra;Maja Starovic

  • Myc requires distinct E2F activities to induce S phase and apoptosis.

    Gustavo Leone;Rosalie Sears;Erich Huang;Rachel Rempel

  • The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.

    E J Smith;G Leone;J DeGregori;L Jakoi

  • Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

    A. Bronisz;J. Godlewski;J. A. Wallace;A.S. Merchant

  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

    Zhen Yan;James DeGregori;Ralph Shohet;Gustavo Leone

  • Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation.

    Alain de Bruin;Baidehi Maiti;Laszlo Jakoi;Cynthia Timmers

  • E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

    James DeGregori;Gustavo Leone;Kiyoshi Ohtani;Alexander Miron

  • E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.

    Jean Leon Chong;Pamela L. Wenzel;M. Teresa Sáenz-Robles;Vivek Nair;Vivek Nair

  • Role of the Rb/E2F pathway in cell growth control.

    Joseph R. Nevins;Gustavo Leone;James DeGregori;Laszlo Jakoi

  • Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer

    Zahida Qamri;Anju Preet;Anju Preet;Mohd W. Nasser;Caroline E. Bass

Frequent Co-Authors

Michael C. Ostrowski
Michael C. Ostrowski Medical University of South Carolina
Raghu Machiraju
Raghu Machiraju The Ohio State University
Joseph R. Nevins
Joseph R. Nevins Duke University
Alain de Bruin
Alain de Bruin Utrecht University
James DeGregori
James DeGregori University of Colorado Anschutz Medical Campus
Patrick W.K. Lee
Patrick W.K. Lee University of Calgary
Joel H. Saltz
Joel H. Saltz Stony Brook University
Michael A. Caligiuri
Michael A. Caligiuri City Of Hope National Medical Center
Rod Bremner
Rod Bremner Lunenfeld-Tanenbaum Research Institute
James M. Pipas
James M. Pipas University of Pittsburgh

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