D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 57 Citations 13,857 100 World Ranking 1955 National Ranking 960

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Disease

Hal M. Hoffman spends much of his time researching Immunology, Cryopyrin-associated periodic syndrome, Inflammasome, Familial Cold Autoinflammatory Syndrome and NALP3. His studies in Immunology integrate themes in fields like Mutation and Genetics, Intracellular. His work deals with themes such as Canakinumab, Rilonacept and Muckle–Wells syndrome, which intersect with Cryopyrin-associated periodic syndrome.

His Inflammasome research incorporates elements of Pharmacology and Cell biology. Hal M. Hoffman combines subjects such as Gouty arthritis, Transporter, Secretion and Pathogenesis with his study of NALP3. His research on Inflammation concerns the broader Internal medicine.

His most cited work include:

  • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity (1529 citations)
  • Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. (1222 citations)
  • The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy (671 citations)

What are the main themes of his work throughout his whole career to date?

Hal M. Hoffman focuses on Immunology, Inflammasome, Inflammation, Internal medicine and Cryopyrin-associated periodic syndrome. His Immunology study frequently draws connections between adjacent fields such as Disease. The concepts of his Inflammasome study are interwoven with issues in Proinflammatory cytokine, Interleukin 18, Macrophage and Cell biology.

His Internal medicine research incorporates themes from Endocrinology, Surgery and Pathology. Hal M. Hoffman works mostly in the field of Cryopyrin-associated periodic syndrome, limiting it down to topics relating to Canakinumab and, in certain cases, Adverse effect, as a part of the same area of interest. His work carried out in the field of Familial Cold Autoinflammatory Syndrome brings together such families of science as Neonatal onset multisystem inflammatory disease, Dermatology, Autoinflammatory Syndrome, NALP3 and Muckle–Wells syndrome.

He most often published in these fields:

  • Immunology (56.85%)
  • Inflammasome (33.50%)
  • Inflammation (32.99%)

What were the highlights of his more recent work (between 2015-2021)?

  • Immunology (56.85%)
  • Inflammasome (33.50%)
  • Inflammation (32.99%)

In recent papers he was focusing on the following fields of study:

Hal M. Hoffman mainly investigates Immunology, Inflammasome, Inflammation, Cell biology and Internal medicine. His research integrates issues of Familial Mediterranean fever and Lung in his study of Immunology. Hal M. Hoffman has included themes like Hepatic stellate cell, Liver injury, Signal transduction, Proinflammatory cytokine and Macrophage in his Inflammasome study.

His primary area of study in Inflammation is in the field of Caspase 1. His Cell biology research includes elements of Choline transporter, Innate immune system and Cellular differentiation. His Familial Cold Autoinflammatory Syndrome study, which is part of a larger body of work in Cryopyrin-associated periodic syndrome, is frequently linked to Pneumococcal polysaccharide vaccine, bridging the gap between disciplines.

Between 2015 and 2021, his most popular works were:

  • NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria (458 citations)
  • A guiding map for inflammation (188 citations)
  • Intestinal fungi contribute to development of alcoholic liver disease (170 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Disease

His main research concerns Immunology, Inflammation, Inflammasome, Familial Mediterranean fever and Immune system. His work on Cryopyrin-associated periodic syndrome as part of his general Immunology study is frequently connected to Extramural, thereby bridging the divide between different branches of science. His Inflammation study combines topics from a wide range of disciplines, such as Bioinformatics, Biological pathway, Cellular Immunology, Immunity and Chronic disease.

His Inflammasome research integrates issues from Tumor necrosis factor alpha, Chemokine, Cell biology, Proinflammatory cytokine and Fibrosis. His Familial Mediterranean fever research focuses on subjects like Recurrent fever, which are linked to Pharyngitis, Hereditary Autoinflammatory Diseases, Canakinumab and Hyperimmunoglobulinemia D. His work in the fields of Immune system, such as Innate immune system, overlaps with other areas such as Life span.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Jorge Alejandro Henao-Mejía;Eran Elinav;Cheng Cheng Jin;Liming Hao.
Nature (2012)

1831 Citations

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome.

Hal M. Hoffman;James L. Mueller;David H. Broide;Alan A. Wanderer.
Nature Genetics (2001)

1593 Citations

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.

Ivona Aksentijevich;Miroslawa Nowak;Mustapha Mallah;Jae Jin Chae.
Arthritis & Rheumatism (2002)

870 Citations

The NLR gene family: a standard nomenclature

Jenny P.Y. Ting;Ruth C. Lovering;Emad S. Alnemri;John Bertin.
Immunity (2008)

858 Citations

The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy

Ralph Knöll;Masahiko Hoshijima;Hal M. Hoffman;Veronika Person.
Cell (2002)

839 Citations

Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity

George Y. Liu;Anthony Essex;John T. Buchanan;Vivekanand Datta.
Journal of Experimental Medicine (2005)

755 Citations

Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.

Hal M. Hoffman;Martin L. Throne;N. J. Amar;Mohamed Sebai.
Arthritis & Rheumatism (2008)

694 Citations

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

Mohamed Lamkanfi;James L. Mueller;Alberto C. Vitari;Shahram Misaghi.
Journal of Cell Biology (2009)

666 Citations

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

Hal M Hoffman;Hal M Hoffman;Sanna Rosengren;David L Boyle;Jae Y Cho.
The Lancet (2004)

597 Citations

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Zhenyu Zhong;Atsushi Umemura;Atsushi Umemura;Elsa Sanchez-Lopez;Shuang Liang.
Cell (2016)

559 Citations

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Seth L. Masters

Seth L. Masters

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Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking d-index is inferred from publications deemed to belong to the considered discipline.

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