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Immunology

D-Index
82
Citations
33737
World Ranking
1481
National Ranking
745

Overview

Hal M. Hoffman is affiliated with the University of California, San Diego in the United States. Their research spans multiple fields of study including Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology, with a significant focus on molecular biology and immunology.

The scientist has contributed extensively to the study of immune system mechanisms and related disorders, with main topics of work including inflammasome and immune disorders, liver disease diagnosis and treatment, and pathways involving IL-33, ST2, and ILC. Other notable research areas are Kawasaki disease and coronary complications, immune response and inflammation, autoimmune and inflammatory disorders, as well as phagocytosis and immune regulation.

Recent papers authored or co-authored by Hoffman highlight active research in inflammasome biology and liver pathology. These include:

  • Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling (2022, Immunity)
  • Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis (2020, Journal of Hepatology)
  • Inhibition of the NLRP3 inflammasome prevents ovarian aging (2021, Science Advances)
  • IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting (2022, Nature Reviews Rheumatology)
  • Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach (2020, Journal of Allergy and Clinical Immunology)

Hoffman frequently collaborates with a range of researchers. Notable co-authors include Lori Broderick, Ariel E. Feldstein, Janset Onyuru, Benedikt Kaufmann, and Ben A. Croker.

The scientist has published consistently in several journals. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Allergy and Clinical Immunology
  • Scientific Reports
  • Journal of Hepatology
  • The Journal of Allergy and Clinical Immunology In Practice

Hoffman's work is interdisciplinary, cutting across molecular biology, immunology, and clinical medicine, with a particular emphasis on the molecular pathways associated with immune activation and inflammation. Their research outputs contribute to understanding the mechanisms underlying autoinflammatory diseases, liver fibrosis, and aging, among others.

Best Publications

  • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

    Jorge Alejandro Henao-Mejía;Eran Elinav;Cheng Cheng Jin;Liming Hao

  • Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

    Hal M. Hoffman;James L. Mueller;David H. Broide;Alan A. Wanderer

  • NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

    Zhenyu Zhong;Atsushi Umemura;Atsushi Umemura;Elsa Sanchez-Lopez;Shuang Liang

  • The NLR gene family: a standard nomenclature

    Jenny P.Y. Ting;Ruth C. Lovering;Emad S. Alnemri;John Bertin

  • Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity

    George Y. Liu;Anthony Essex;John T. Buchanan;Vivekanand Datta

  • De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.

    Ivona Aksentijevich;Miroslawa Nowak;Mustapha Mallah;Jae Jin Chae

  • Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

    Mohamed Lamkanfi;James L. Mueller;Alberto C. Vitari;Shahram Misaghi

  • The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy

    Ralph Knöll;Masahiko Hoshijima;Hal M. Hoffman;Veronika Person

  • NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.

    Alexander Wree;Akiko Eguchi;Matthew D. McGeough;Carla A. Pena

  • A guiding map for inflammation

    Mihai G Netea;Frances Balkwill;Michel Chonchol;Fabio Cominelli

  • Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.

    Hal M. Hoffman;Martin L. Throne;N. J. Amar;Mohamed Sebai

  • Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

    Hal M Hoffman;Hal M Hoffman;Sanna Rosengren;David L Boyle;Jae Y Cho

  • From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

    Alexander Wree;Lori Broderick;Ali Canbay;Hal M. Hoffman

  • Classification criteria for autoinflammatory recurrent fevers

    Marco Gattorno;Michael Hofer;Silvia Federici;Federica Vanoni

  • NLRP3 inflammasome activation is required for fibrosis development in NAFLD.

    Alexander Wree;Matthew D. McGeough;Carla A. Peña;Martin Schlattjan

  • Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

    Susanne Gaul;Susanne Gaul;Aleksandra Leszczynska;Fernando Alegre;Fernando Alegre;Benedikt Kaufmann

  • Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy

    Jiujiu Yu;Hajime Nagasu;Tomohiko Murakami;Hai Hoang

  • Neutrophils: New insights and open questions

    Klaus Ley;Klaus Ley;Hal M. Hoffman;Paul Kubes;Marco A. Cassatella

  • Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes

    Fabrizio De Benedetti;Marco Gattorno;Jordi Anton;Eldad Ben-Chetrit

  • CATERPILLERs, pyrin and hereditary immunological disorders

    Jenny P.-Y. Ting;Daniel L. Kastner;Hal M. Hoffman

  • Intestinal fungi contribute to development of alcoholic liver disease

    An Ming Yang;Tatsuo Inamine;Tatsuo Inamine;Katrin Hochrath;Peng Chen

  • The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model.

    Ivona Aksentijevich;Christopher D. Putnam;Elaine F. Remmers;James L. Mueller

  • Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

    Michael J. Ombrello;Elaine F. Remmers;Guangping Sun;Alexandra F. Freeman

  • IL-1 family nomenclature

    Charles Dinarello;William Arend;John Sims;Dirk Smith

Frequent Co-Authors

Ariel E. Feldstein
Ariel E. Feldstein University of California, San Diego
Victor Nizet
Victor Nizet University of California, San Diego
Christopher D. Putnam
Christopher D. Putnam University of California, San Diego
David H. Broide
David H. Broide University of California, San Diego
Daniel L. Kastner
Daniel L. Kastner National Institutes of Health
Raphaela Goldbach-Mansky
Raphaela Goldbach-Mansky National Institute of Allergy and Infectious Diseases
Richard D. Kolodner
Richard D. Kolodner University of California, San Diego
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Ivona Aksentijevich
Ivona Aksentijevich National Institutes of Health
Helen J. Lachmann
Helen J. Lachmann University College London

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