World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
82
Citations
33737
World Ranking
1481
National Ranking
745

Hal M. Hoffman publication distribution in Immunology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Immunology in 2026. The highlighted bar marks where Hal M. Hoffman sits on this spectrum.

62–71 publications: 9 scientists 72–81 publications: 23 scientists 82–91 publications: 40 scientists 92–101 publications: 72 scientists 102–111 publications: 86 scientists 112–121 publications: 108 scientists 122–131 publications: 150 scientists 132–141 publications: 160 scientists 142–151 publications: 159 scientists 152–161 publications: 189 scientists 162–171 publications: 166 scientists 172–181 publications: 181 scientists 182–191 publications: 188 scientists 192–201 publications: 187 scientists 202–211 publications: 178 scientists 212–221 publications: 158 scientists 222–231 publications: 168 scientists 232–241 publications: 159 scientists 242–251 publications: 160 scientists 252–261 publications: 148 scientists 262–271 publications: 116 scientists 272–281 publications: 125 scientists 282–291 publications: 115 scientists 292–301 publications: 111 scientists 302–311 publications: 95 scientists 312–321 publications: 97 scientists 322–331 publications: 97 scientists 332–341 publications: 99 scientists 342–351 publications: 96 scientists 352–361 publications: 68 scientists 362–371 publications: 76 scientists 372–381 publications: 71 scientists 382–391 publications: 71 scientists 392–401 publications: 62 scientists 402–411 publications: 54 scientists 412–421 publications: 41 scientists 422–431 publications: 63 scientists 432–441 publications: 53 scientists 442–451 publications: 31 scientists 452–461 publications: 42 scientists 462–471 publications: 40 scientists 472–481 publications: 29 scientists 482–491 publications: 34 scientists 492–501 publications: 30 scientists 502–511 publications: 23 scientists 512–521 publications: 41 scientists 522–531 publications: 29 scientists 532–541 publications: 28 scientists 542–551 publications: 16 scientists 552–561 publications: 18 scientists 562–571 publications: 18 scientists 572–581 publications: 17 scientists 582–591 publications: 17 scientists 592–601 publications: 17 scientists 602–611 publications: 19 scientists 612–621 publications: 13 scientists 622–631 publications: 12 scientists 632–641 publications: 11 scientists 642–651 publications: 16 scientists 652–661 publications: 9 scientists 662–671 publications: 5 scientists 672–681 publications: 13 scientists 682–691 publications: 12 scientists 692–701 publications: 6 scientists 702–711 publications: 6 scientists 712–721 publications: 9 scientists 722–731 publications: 9 scientists 732–741 publications: 6 scientists 742–751 publications: 11 scientists 752–761 publications: 10 scientists 762–771 publications: 7 scientists 772–781 publications: 12 scientists 782–791 publications: 7 scientists 792–801 publications: 5 scientists 802–806 publications: 1 scientists 807+ publications: 100 scientists
62 publications 807+

This scientist: 237 publications — 47th percentile

47% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 807 publications or more.

Hal M. Hoffman D-index placement in Immunology in 2026

The chart shows the D-index (discipline H-index) distribution of Immunology scientists ranked by Research.com in 2026. The highlighted bar marks where Hal M. Hoffman sits on this spectrum.

40–41 D-Index: 28 scientists 42–43 D-Index: 91 scientists 44–45 D-Index: 157 scientists 46–47 D-Index: 192 scientists 48–49 D-Index: 175 scientists 50–51 D-Index: 188 scientists 52–53 D-Index: 177 scientists 54–55 D-Index: 155 scientists 56–57 D-Index: 194 scientists 58–59 D-Index: 201 scientists 60–61 D-Index: 197 scientists 62–63 D-Index: 201 scientists 64–65 D-Index: 173 scientists 66–67 D-Index: 167 scientists 68–69 D-Index: 172 scientists 70–71 D-Index: 199 scientists 72–73 D-Index: 184 scientists 74–75 D-Index: 133 scientists 76–77 D-Index: 162 scientists 78–79 D-Index: 127 scientists 80–81 D-Index: 121 scientists 82–83 D-Index: 125 scientists 84–85 D-Index: 121 scientists 86–87 D-Index: 102 scientists 88–89 D-Index: 96 scientists 90–91 D-Index: 75 scientists 92–93 D-Index: 72 scientists 94–95 D-Index: 74 scientists 96–97 D-Index: 66 scientists 98–99 D-Index: 68 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 60 scientists 104–105 D-Index: 54 scientists 106–107 D-Index: 36 scientists 108–109 D-Index: 23 scientists 110–111 D-Index: 52 scientists 112–113 D-Index: 41 scientists 114–115 D-Index: 34 scientists 116–117 D-Index: 25 scientists 118–119 D-Index: 28 scientists 120–121 D-Index: 11 scientists 122–123 D-Index: 20 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 19 scientists 128–129 D-Index: 20 scientists 130–131 D-Index: 16 scientists 132–133 D-Index: 17 scientists 134–135 D-Index: 14 scientists 136–137 D-Index: 15 scientists 138–139 D-Index: 9 scientists 140–141 D-Index: 11 scientists 142–143 D-Index: 9 scientists 144–145 D-Index: 9 scientists 146–147 D-Index: 7 scientists 148–149 D-Index: 7 scientists 150–151 D-Index: 7 scientists 152–153 D-Index: 5 scientists 154–155 D-Index: 8 scientists 156 D-Index: 6 scientists 157+ D-Index: 96 scientists
40 D-Index 157+

This scientist: 82 D-Index — 70th percentile

70% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 157 D-Index or more.

Overview

Hal M. Hoffman is affiliated with the University of California, San Diego in the United States. Their research spans multiple fields of study including Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology, with a significant focus on molecular biology and immunology.

The scientist has contributed extensively to the study of immune system mechanisms and related disorders, with main topics of work including inflammasome and immune disorders, liver disease diagnosis and treatment, and pathways involving IL-33, ST2, and ILC. Other notable research areas are Kawasaki disease and coronary complications, immune response and inflammation, autoimmune and inflammatory disorders, as well as phagocytosis and immune regulation.

Recent papers authored or co-authored by Hoffman highlight active research in inflammasome biology and liver pathology. These include:

  • Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling (2022, Immunity)
  • Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis (2020, Journal of Hepatology)
  • Inhibition of the NLRP3 inflammasome prevents ovarian aging (2021, Science Advances)
  • IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting (2022, Nature Reviews Rheumatology)
  • Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach (2020, Journal of Allergy and Clinical Immunology)

Hoffman frequently collaborates with a range of researchers. Notable co-authors include Lori Broderick, Ariel E. Feldstein, Janset Onyuru, Benedikt Kaufmann, and Ben A. Croker.

The scientist has published consistently in several journals. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Allergy and Clinical Immunology
  • Scientific Reports
  • Journal of Hepatology
  • The Journal of Allergy and Clinical Immunology In Practice

Hoffman's work is interdisciplinary, cutting across molecular biology, immunology, and clinical medicine, with a particular emphasis on the molecular pathways associated with immune activation and inflammation. Their research outputs contribute to understanding the mechanisms underlying autoinflammatory diseases, liver fibrosis, and aging, among others.

Best Publications

  • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

    Jorge Alejandro Henao-Mejía;Eran Elinav;Cheng Cheng Jin;Liming Hao

  • Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

    Hal M. Hoffman;James L. Mueller;David H. Broide;Alan A. Wanderer

  • NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

    Zhenyu Zhong;Atsushi Umemura;Atsushi Umemura;Elsa Sanchez-Lopez;Shuang Liang

  • The NLR gene family: a standard nomenclature

    Jenny P.Y. Ting;Ruth C. Lovering;Emad S. Alnemri;John Bertin

  • Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity

    George Y. Liu;Anthony Essex;John T. Buchanan;Vivekanand Datta

  • De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.

    Ivona Aksentijevich;Miroslawa Nowak;Mustapha Mallah;Jae Jin Chae

  • Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

    Mohamed Lamkanfi;James L. Mueller;Alberto C. Vitari;Shahram Misaghi

  • The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy

    Ralph Knöll;Masahiko Hoshijima;Hal M. Hoffman;Veronika Person

  • NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.

    Alexander Wree;Akiko Eguchi;Matthew D. McGeough;Carla A. Pena

  • A guiding map for inflammation

    Mihai G Netea;Frances Balkwill;Michel Chonchol;Fabio Cominelli

  • Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.

    Hal M. Hoffman;Martin L. Throne;N. J. Amar;Mohamed Sebai

  • Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

    Hal M Hoffman;Hal M Hoffman;Sanna Rosengren;David L Boyle;Jae Y Cho

  • From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

    Alexander Wree;Lori Broderick;Ali Canbay;Hal M. Hoffman

  • Classification criteria for autoinflammatory recurrent fevers

    Marco Gattorno;Michael Hofer;Silvia Federici;Federica Vanoni

  • NLRP3 inflammasome activation is required for fibrosis development in NAFLD.

    Alexander Wree;Matthew D. McGeough;Carla A. Peña;Martin Schlattjan

  • Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

    Susanne Gaul;Susanne Gaul;Aleksandra Leszczynska;Fernando Alegre;Fernando Alegre;Benedikt Kaufmann

  • Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy

    Jiujiu Yu;Hajime Nagasu;Tomohiko Murakami;Hai Hoang

  • Neutrophils: New insights and open questions

    Klaus Ley;Klaus Ley;Hal M. Hoffman;Paul Kubes;Marco A. Cassatella

  • Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes

    Fabrizio De Benedetti;Marco Gattorno;Jordi Anton;Eldad Ben-Chetrit

  • CATERPILLERs, pyrin and hereditary immunological disorders

    Jenny P.-Y. Ting;Daniel L. Kastner;Hal M. Hoffman

  • Intestinal fungi contribute to development of alcoholic liver disease

    An Ming Yang;Tatsuo Inamine;Tatsuo Inamine;Katrin Hochrath;Peng Chen

  • The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model.

    Ivona Aksentijevich;Christopher D. Putnam;Elaine F. Remmers;James L. Mueller

  • Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

    Michael J. Ombrello;Elaine F. Remmers;Guangping Sun;Alexandra F. Freeman

  • IL-1 family nomenclature

    Charles Dinarello;William Arend;John Sims;Dirk Smith

Frequent Co-Authors

Ariel E. Feldstein
Ariel E. Feldstein University of California, San Diego
Victor Nizet
Victor Nizet University of California, San Diego
Christopher D. Putnam
Christopher D. Putnam University of California, San Diego
David H. Broide
David H. Broide University of California, San Diego
Daniel L. Kastner
Daniel L. Kastner National Institutes of Health
Raphaela Goldbach-Mansky
Raphaela Goldbach-Mansky National Institute of Allergy and Infectious Diseases
Richard D. Kolodner
Richard D. Kolodner University of California, San Diego
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Ivona Aksentijevich
Ivona Aksentijevich National Institutes of Health
Helen J. Lachmann
Helen J. Lachmann University College London

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