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Molecular Biology

D-Index
126
Citations
60867
World Ranking
213
National Ranking
13

Research.com Recognitions

  • 2013 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Kristian Helin is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their primary research contributions lie within biochemistry, genetics, and molecular biology, with a significant focus on molecular biology.

The scientist's recent publications cover key issues in epigenetics, chromatin dynamics, and gene regulation related to cancer and hematology. Notable papers include:

  • H3K4me3 regulates RNA polymerase II promoter-proximal pause-release, 2023, Nature
  • Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals, 2022, Nature Genetics
  • KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes, 2020, Nature Cell Biology
  • Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis, 2021, Molecular Cell
  • TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis, 2021, Nature Communications

Kristian Helin's research traverses several main topics, including:

  • Epigenetics and DNA methylation
  • RNA modifications and cancer
  • Cancer-related gene regulation
  • Genomics and chromatin dynamics
  • Acute myeloid leukemia research
  • CRISPR and genetic engineering
  • Protein degradation and inhibitors

Frequent coauthors collaborating extensively with Helin include:

  • Richard P. Koche
  • Hua Wang
  • Pavel V. Shliaha
  • Karl Agger
  • Aliaksandra Radzisheuskaya

Their work has appeared predominantly in the following publication venues:

  • Molecular Cell
  • Nature Communications
  • Nature
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)

Kristian Helin's research has established a significant presence in areas intersecting molecular biology, genetics, and cancer research, focusing particularly on mechanisms regulating chromatin and epigenetic modifications in health and disease contexts.

In recognition of their scientific contributions, Helin has been named a member of the Academia Europaea since 2013 and is also a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

    Adrian P. Bracken;Nikolaj Dietrich;Diego Pasini;Klaus H. Hansen

  • UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.

    Karl Agger;Paul A. C. Cloos;Jesper Christensen;Diego Pasini

  • EZH2 is downstream of the pRB‐E2F pathway, essential for proliferation and amplified in cancer

    Adrian P. Bracken;Diego Pasini;Maria Capra;Elena Prosperini

  • TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

    Kristine Williams;Jesper Christensen;Marianne Terndrup Pedersen;Jens V. Johansen

  • Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

    Diego Pasini;Adrian P Bracken;Michael R Jensen;Eros Lazzerini Denchi

  • The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

    Adrian P. Bracken;Daniela Kleine-Kohlbrecher;Nikolaj Dietrich;Diego Pasini

  • Role of TET enzymes in DNA methylation, development, and cancer

    Kasper Dindler Rasmussen;Kristian Helin

  • Transcriptional regulation by Polycomb group proteins.

    Luciano Di Croce;Luciano Di Croce;Kristian Helin

  • Molecular mechanisms and potential functions of histone demethylases.

    Susanne Marije Kooistra;Kristian Helin

  • E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

    Heiko Müller;Adrian P. Bracken;Richard Vernell;M. Cristina Moroni

  • The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

    Paul A C Cloos;Jesper Christensen;Karl Agger;Alessio Maiolica

  • Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

    Sebastian Bender;Sebastian Bender;Yujie Tang;Anders M. Lindroth;Volker Hovestadt

  • A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

    Kristian Helin;Jacqueline A. Lees;Marc Vidal;Nicholas Dyson

  • A model for transmission of the H3K27me3 epigenetic mark

    Klaus H. Hansen;Adrian P. Bracken;Adrian P. Bracken;Diego Pasini;Nikolaj Dietrich

  • The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

    Diego Pasini;Adrian P. Bracken;Jacob B. Hansen;Manuela Capillo

  • Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

    Paul A.C. Cloos;Jesper Christensen;Karl Agger;Kristian Helin

  • Apaf-1 is a transcriptional target for E2F and p53

    M. Cristina Moroni;Emma S. Hickman;Eros Lazzerini Denchi;Greta Caprara

  • Polycomb group proteins: navigators of lineage pathways led astray in cancer

    Adrian P. Bracken;Kristian Helin

  • Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

    Liang Zhu;S. Van Den Heuvel;K. Helin;Ali Fattaey

  • The E2F family: specific functions and overlapping interests

    Claire Attwooll;Eros Lazzerini Denchi;Kristian Helin

Frequent Co-Authors

Diego Pasini
Diego Pasini European Institute of Oncology
Ole Nørregaard Jensen
Ole Nørregaard Jensen University of Southern Denmark
Juri Rappsilber
Juri Rappsilber Technical University of Berlin
Ed Harlow
Ed Harlow Harvard University
Pier Giuseppe Pelicci
Pier Giuseppe Pelicci European Institute of Oncology
Simone Sidoli
Simone Sidoli Albert Einstein College of Medicine
Bo T. Porse
Bo T. Porse University of Copenhagen
Claus Storgaard Sørensen
Claus Storgaard Sørensen University of Copenhagen
Nicholas J. Dyson
Nicholas J. Dyson Harvard University

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